Effect of nesfatin-1 on the nutritional status of hemodialysis patients
Background Nesfatin-1 is considered an anorexigenic peptide that plays an important role in appetite regulation, weight loss, and malnutrition. Although the cause of anorexia in CKD patients is not totally understood, both anorexia and malnutrition are common presentations of chronic kidney disease...
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| Format: | Article |
| Language: | English |
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General Organization of Teaching Hospitals and Institutes
2022-01-01
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| Series: | Journal of Medicine in Scientific Research |
| Subjects: | |
| Online Access: | http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2022;volume=5;issue=3;spage=385;epage=392;aulast=Elsayed |
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| author | Huda M Elsayed Nagwa Abd El-Ghaffar Mohamed Ahmed H M. Elthakaby Karima Youssef Ahmed Ragaa R Mohamed Hany Y Esso |
| author_facet | Huda M Elsayed Nagwa Abd El-Ghaffar Mohamed Ahmed H M. Elthakaby Karima Youssef Ahmed Ragaa R Mohamed Hany Y Esso |
| author_sort | Huda M Elsayed |
| collection | DOAJ |
| description | Background
Nesfatin-1 is considered an anorexigenic peptide that plays an important role in appetite regulation, weight loss, and malnutrition. Although the cause of anorexia in CKD patients is not totally understood, both anorexia and malnutrition are common presentations of chronic kidney disease (CKD) patients who are susceptible to worse outcomes.
Our aim of the work
To study the relation of serum nesfatin-1 and its relation to the nutritional status of end-stage renal disease (ESRD), who are maintained on regular hemodialysis.
Patients and methods
A total of 60 ESRD patients are maintained on regular hemodialysis, and apparently healthy thirty persons (control group) were included in this study. Those included represented 45 males and 45 females with an age range from 19 to 68 years old. Based on malnutrition inflammation score (MIS), we had three groups, the first & second group, each included 30 ESRD patients maintained on regular HD without & with malnutrition respectively. 3rd group included 30 apparently healthy control persons; all subjects were exposed to full history, clinical examination, MIS questioner, and lab. Tests in the form of Complete blood count, liver function test, Kidney Function test, s.Calcium, Phosphrus, Parathyroid hormone, iron profile, C reactive protein titer, interleukin 6, and serum nesfatin 1.
Results
There were significant increases in s. nesfatin-1 and CRP levels in groups 1, 2 more than that of the control group, with a significant increase in group 2 in comparison to other groups. Group 2 had a statistically significantly increase of IL6 and MIS when compared to group 1. In group 2. while there was a highly significant positive correlation between nesfatin-1with MIS and IL6, but a significantly negative correlation with BMI, Ph. and serum parathyroid hormone. In group 1, while there was a highly significant positive correlation between nesfatin-1with MIS and IL6, a significantly positive correlation with duration of dialysis but a significantly negative correlation with ferritin, calcium, and cholesterol. The cutoff level in group1 patients versus group 2 was more than 16.6, with a sensitivity of 56.7% and specificity of 83.3%. In conclusion, s. nesfatin-1 is specific for the detection of malnutrition in hemodialysis patients. |
| first_indexed | 2024-04-24T15:03:48Z |
| format | Article |
| id | doaj.art-062aa17766cb40a2a6f369915e3ca022 |
| institution | Directory Open Access Journal |
| issn | 2537-091X 2537-0928 |
| language | English |
| last_indexed | 2024-04-24T15:03:48Z |
| publishDate | 2022-01-01 |
| publisher | General Organization of Teaching Hospitals and Institutes |
| record_format | Article |
| series | Journal of Medicine in Scientific Research |
| spelling | doaj.art-062aa17766cb40a2a6f369915e3ca0222024-04-02T14:02:11ZengGeneral Organization of Teaching Hospitals and InstitutesJournal of Medicine in Scientific Research2537-091X2537-09282022-01-015338539210.4103/jmisr.jmisr_31_21Effect of nesfatin-1 on the nutritional status of hemodialysis patientsHuda M ElsayedNagwa Abd El-Ghaffar MohamedAhmed H M. ElthakabyKarima Youssef AhmedRagaa R MohamedHany Y EssoBackground Nesfatin-1 is considered an anorexigenic peptide that plays an important role in appetite regulation, weight loss, and malnutrition. Although the cause of anorexia in CKD patients is not totally understood, both anorexia and malnutrition are common presentations of chronic kidney disease (CKD) patients who are susceptible to worse outcomes. Our aim of the work To study the relation of serum nesfatin-1 and its relation to the nutritional status of end-stage renal disease (ESRD), who are maintained on regular hemodialysis. Patients and methods A total of 60 ESRD patients are maintained on regular hemodialysis, and apparently healthy thirty persons (control group) were included in this study. Those included represented 45 males and 45 females with an age range from 19 to 68 years old. Based on malnutrition inflammation score (MIS), we had three groups, the first & second group, each included 30 ESRD patients maintained on regular HD without & with malnutrition respectively. 3rd group included 30 apparently healthy control persons; all subjects were exposed to full history, clinical examination, MIS questioner, and lab. Tests in the form of Complete blood count, liver function test, Kidney Function test, s.Calcium, Phosphrus, Parathyroid hormone, iron profile, C reactive protein titer, interleukin 6, and serum nesfatin 1. Results There were significant increases in s. nesfatin-1 and CRP levels in groups 1, 2 more than that of the control group, with a significant increase in group 2 in comparison to other groups. Group 2 had a statistically significantly increase of IL6 and MIS when compared to group 1. In group 2. while there was a highly significant positive correlation between nesfatin-1with MIS and IL6, but a significantly negative correlation with BMI, Ph. and serum parathyroid hormone. In group 1, while there was a highly significant positive correlation between nesfatin-1with MIS and IL6, a significantly positive correlation with duration of dialysis but a significantly negative correlation with ferritin, calcium, and cholesterol. The cutoff level in group1 patients versus group 2 was more than 16.6, with a sensitivity of 56.7% and specificity of 83.3%. In conclusion, s. nesfatin-1 is specific for the detection of malnutrition in hemodialysis patients.http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2022;volume=5;issue=3;spage=385;epage=392;aulast=Elsayedhemodialysis patientmalnutritionnestatin-1 |
| spellingShingle | Huda M Elsayed Nagwa Abd El-Ghaffar Mohamed Ahmed H M. Elthakaby Karima Youssef Ahmed Ragaa R Mohamed Hany Y Esso Effect of nesfatin-1 on the nutritional status of hemodialysis patients Journal of Medicine in Scientific Research hemodialysis patient malnutrition nestatin-1 |
| title | Effect of nesfatin-1 on the nutritional status of hemodialysis patients |
| title_full | Effect of nesfatin-1 on the nutritional status of hemodialysis patients |
| title_fullStr | Effect of nesfatin-1 on the nutritional status of hemodialysis patients |
| title_full_unstemmed | Effect of nesfatin-1 on the nutritional status of hemodialysis patients |
| title_short | Effect of nesfatin-1 on the nutritional status of hemodialysis patients |
| title_sort | effect of nesfatin 1 on the nutritional status of hemodialysis patients |
| topic | hemodialysis patient malnutrition nestatin-1 |
| url | http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2022;volume=5;issue=3;spage=385;epage=392;aulast=Elsayed |
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