The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development
Neural cell type diversification during development is a complex and highly regulated process. Here, the authors show that the histone H3-lysine 27 demethylase Kdm6b promotes and inhibits the generation of specific motor neuron subtypes during the development of the mouse spinal cord.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28636-7 |
| _version_ | 1819277681030594560 |
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| author | Wenxian Wang Hyeyoung Cho Jae W. Lee Soo-Kyung Lee |
| author_facet | Wenxian Wang Hyeyoung Cho Jae W. Lee Soo-Kyung Lee |
| author_sort | Wenxian Wang |
| collection | DOAJ |
| description | Neural cell type diversification during development is a complex and highly regulated process. Here, the authors show that the histone H3-lysine 27 demethylase Kdm6b promotes and inhibits the generation of specific motor neuron subtypes during the development of the mouse spinal cord. |
| first_indexed | 2024-12-23T23:59:58Z |
| format | Article |
| id | doaj.art-062c1eb9ac744beabb24be848c8cc4ea |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T23:59:58Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-062c1eb9ac744beabb24be848c8cc4ea2022-12-21T17:25:09ZengNature PortfolioNature Communications2041-17232022-02-0113112210.1038/s41467-022-28636-7The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during developmentWenxian Wang0Hyeyoung Cho1Jae W. Lee2Soo-Kyung Lee3Department of Biological Sciences, College of Arts and Sciences, University at Buffalo, The State University of New York (SUNY)Computational Biology Program, School of Medicine, Oregon Health & Science UniversityDepartment of Biological Sciences, College of Arts and Sciences, University at Buffalo, The State University of New York (SUNY)Department of Biological Sciences, College of Arts and Sciences, University at Buffalo, The State University of New York (SUNY)Neural cell type diversification during development is a complex and highly regulated process. Here, the authors show that the histone H3-lysine 27 demethylase Kdm6b promotes and inhibits the generation of specific motor neuron subtypes during the development of the mouse spinal cord.https://doi.org/10.1038/s41467-022-28636-7 |
| spellingShingle | Wenxian Wang Hyeyoung Cho Jae W. Lee Soo-Kyung Lee The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development Nature Communications |
| title | The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development |
| title_full | The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development |
| title_fullStr | The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development |
| title_full_unstemmed | The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development |
| title_short | The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development |
| title_sort | histone demethylase kdm6b regulates subtype diversification of mouse spinal motor neurons during development |
| url | https://doi.org/10.1038/s41467-022-28636-7 |
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