Antibiotic Resistance Pattern of Bacterial Agents Isolated from Blood Culture of Patients with Infective Endocarditis
Background and purpose: The prevalence of bacterial infections and the type of bacteria involved in causing endocarditis and knowing their antibiotic resistance pattern are very important for the correct selection of antibiotics to treat these infections and the proper control of infection in the ho...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2023-12-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-20036-en.pdf |
| _version_ | 1797359806593368064 |
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| author | Ghazale Hamedani Rozita Jalalian Alireza Davoudi Badabi Maryam Mirzakhani Mona Moshiri Mehrdad Gholami |
| author_facet | Ghazale Hamedani Rozita Jalalian Alireza Davoudi Badabi Maryam Mirzakhani Mona Moshiri Mehrdad Gholami |
| author_sort | Ghazale Hamedani |
| collection | DOAJ |
| description | Background and purpose: The prevalence of bacterial infections and the type of bacteria involved in causing endocarditis and knowing their antibiotic resistance pattern are very important for the correct selection of antibiotics to treat these infections and the proper control of infection in the hospital. In this retrospective cross-sectional descriptive study, we investigated the antibiotic resistance pattern of bacterial agents isolated from blood cultures of patients with infective endocarditis.
Materials and methods: This retrospective study was conducted on patients with infective endocarditis admitted to Razi and Fatemeh Zahra teaching hospitals over the four years from 2019 to 2023. After collecting the data, it was entered into Excel software and then analyzed using SPSS version 19 software.
Results: Among 28 patients included in the study, 57.1% were men and 42.9% were women; the median age of patients was 56.79±13.41 years. The most common isolated microorganism was Staphylococcus aureus with 11 positive samples (39.2%). Ninety-three percent of the studied microorganisms were resistant to at least two drugs. The result of the treatment was not significantly related to any of the gender, type of valve, and type of isolated microorganism (P=0.624, P=1.000 and P=0.398, respectively).
Conclusion: In this study, gram-positive bacteria were the most common group of microorganisms causing infective endocarditis. A high percentage of resistance was observed against some antibiotics including penicillin, ceftazidime, and ceftriaxone, which should be considered in initial empiric antibiotic therapy among hospitalized patients with infective endocarditis |
| first_indexed | 2024-03-08T15:29:06Z |
| format | Article |
| id | doaj.art-062cae3626db4032be11e475397fa3d8 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-03-08T15:29:06Z |
| publishDate | 2023-12-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-062cae3626db4032be11e475397fa3d82024-01-10T06:52:06ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792023-12-013322894103Antibiotic Resistance Pattern of Bacterial Agents Isolated from Blood Culture of Patients with Infective EndocarditisGhazale Hamedani0Rozita Jalalian1Alireza Davoudi Badabi2Maryam Mirzakhani3Mona Moshiri4Mehrdad Gholami5 Medical Student, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Cardiovascular Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Antimicrobial Resistance Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran BSc in Nursing, Fatemeh Zahra Hospital, Mazandaran University of Medical Sciences, Sari, Iran PhD Student in Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Antimicrobial Resistance Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: The prevalence of bacterial infections and the type of bacteria involved in causing endocarditis and knowing their antibiotic resistance pattern are very important for the correct selection of antibiotics to treat these infections and the proper control of infection in the hospital. In this retrospective cross-sectional descriptive study, we investigated the antibiotic resistance pattern of bacterial agents isolated from blood cultures of patients with infective endocarditis. Materials and methods: This retrospective study was conducted on patients with infective endocarditis admitted to Razi and Fatemeh Zahra teaching hospitals over the four years from 2019 to 2023. After collecting the data, it was entered into Excel software and then analyzed using SPSS version 19 software. Results: Among 28 patients included in the study, 57.1% were men and 42.9% were women; the median age of patients was 56.79±13.41 years. The most common isolated microorganism was Staphylococcus aureus with 11 positive samples (39.2%). Ninety-three percent of the studied microorganisms were resistant to at least two drugs. The result of the treatment was not significantly related to any of the gender, type of valve, and type of isolated microorganism (P=0.624, P=1.000 and P=0.398, respectively). Conclusion: In this study, gram-positive bacteria were the most common group of microorganisms causing infective endocarditis. A high percentage of resistance was observed against some antibiotics including penicillin, ceftazidime, and ceftriaxone, which should be considered in initial empiric antibiotic therapy among hospitalized patients with infective endocarditishttp://jmums.mazums.ac.ir/article-1-20036-en.pdfantibioticantimicrobial resistancebacterial infectionsendocarditis |
| spellingShingle | Ghazale Hamedani Rozita Jalalian Alireza Davoudi Badabi Maryam Mirzakhani Mona Moshiri Mehrdad Gholami Antibiotic Resistance Pattern of Bacterial Agents Isolated from Blood Culture of Patients with Infective Endocarditis Journal of Mazandaran University of Medical Sciences antibiotic antimicrobial resistance bacterial infections endocarditis |
| title | Antibiotic Resistance Pattern of Bacterial Agents Isolated from Blood Culture of Patients with Infective Endocarditis |
| title_full | Antibiotic Resistance Pattern of Bacterial Agents Isolated from Blood Culture of Patients with Infective Endocarditis |
| title_fullStr | Antibiotic Resistance Pattern of Bacterial Agents Isolated from Blood Culture of Patients with Infective Endocarditis |
| title_full_unstemmed | Antibiotic Resistance Pattern of Bacterial Agents Isolated from Blood Culture of Patients with Infective Endocarditis |
| title_short | Antibiotic Resistance Pattern of Bacterial Agents Isolated from Blood Culture of Patients with Infective Endocarditis |
| title_sort | antibiotic resistance pattern of bacterial agents isolated from blood culture of patients with infective endocarditis |
| topic | antibiotic antimicrobial resistance bacterial infections endocarditis |
| url | http://jmums.mazums.ac.ir/article-1-20036-en.pdf |
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