Clinical Efficacy of Controlled-Release Morphine Tablets Combined with Celecoxib in Pain Management and the Effects on WNK1 Expression
OBJECTIVES: This study was designed to evaluate the clinical efficacy of controlled-release morphine tablets combined with celecoxib in relieving osteocarcinoma-related pain and the effects of the combination on WNK1 expression. METHODS: A total of 110 patients with osteocarcinoma-related pain were...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2021-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100203&tlng=en |
| _version_ | 1818859371385323520 |
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| author | Jian Li Fanghai Luan Jiangfeng Song Jianhua Dong Mingfu Shang |
| author_facet | Jian Li Fanghai Luan Jiangfeng Song Jianhua Dong Mingfu Shang |
| author_sort | Jian Li |
| collection | DOAJ |
| description | OBJECTIVES: This study was designed to evaluate the clinical efficacy of controlled-release morphine tablets combined with celecoxib in relieving osteocarcinoma-related pain and the effects of the combination on WNK1 expression. METHODS: A total of 110 patients with osteocarcinoma-related pain were selected and divided into two groups based on the treatment administered, including the control group (treated with controlled-release morphine tablets alone) and the study group (treated with a combination of controlled-release morphine tablets and celecoxib). We compared the treatment efficacy, pain level (visual analog scale (VAS)), time of onset of breakthrough pain (BTP), dose of morphine, incidence of adverse events, quality of life (QOL) score, and With-no-lysine 1 (WNK1) expression in the peripheral blood (PB) as determined with qRT-PCR before and after treatment, of the two groups. RESULTS: The total effective rate of the study group was higher than that of the control group, while the VAS score, time of onset of BTP, dose of morphine, incidence of adverse events, QOL score, and relative WNK1 expression in the PB were lower than those of the control group (p<0.05). CONCLUSION: Combination treatment with controlled-release morphine tablets and celecoxib can be extensively used in the clinical setting because it effectively improves the symptoms, QOL score, and adverse effects in patients with osteocarcinoma-related pain. |
| first_indexed | 2024-12-19T09:11:07Z |
| format | Article |
| id | doaj.art-063046b0166844648eb22b6378afe1f4 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-12-19T09:11:07Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-063046b0166844648eb22b6378afe1f42022-12-21T20:28:11ZengElsevier EspañaClinics1980-53222021-01-017610.6061/clinics/2021/e1907Clinical Efficacy of Controlled-Release Morphine Tablets Combined with Celecoxib in Pain Management and the Effects on WNK1 ExpressionJian Lihttps://orcid.org/0000-0003-1980-2487Fanghai Luanhttps://orcid.org/0000-0001-9436-2560Jiangfeng Songhttps://orcid.org/0000-0001-5269-0785Jianhua Donghttps://orcid.org/0000-0003-0496-6067Mingfu Shanghttps://orcid.org/0000-0001-7982-777XOBJECTIVES: This study was designed to evaluate the clinical efficacy of controlled-release morphine tablets combined with celecoxib in relieving osteocarcinoma-related pain and the effects of the combination on WNK1 expression. METHODS: A total of 110 patients with osteocarcinoma-related pain were selected and divided into two groups based on the treatment administered, including the control group (treated with controlled-release morphine tablets alone) and the study group (treated with a combination of controlled-release morphine tablets and celecoxib). We compared the treatment efficacy, pain level (visual analog scale (VAS)), time of onset of breakthrough pain (BTP), dose of morphine, incidence of adverse events, quality of life (QOL) score, and With-no-lysine 1 (WNK1) expression in the peripheral blood (PB) as determined with qRT-PCR before and after treatment, of the two groups. RESULTS: The total effective rate of the study group was higher than that of the control group, while the VAS score, time of onset of BTP, dose of morphine, incidence of adverse events, QOL score, and relative WNK1 expression in the PB were lower than those of the control group (p<0.05). CONCLUSION: Combination treatment with controlled-release morphine tablets and celecoxib can be extensively used in the clinical setting because it effectively improves the symptoms, QOL score, and adverse effects in patients with osteocarcinoma-related pain.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100203&tlng=enControlled-release Morphine TabletsCelecoxibOsteocarcinoma-Related PainClinical EfficacyWNK1 |
| spellingShingle | Jian Li Fanghai Luan Jiangfeng Song Jianhua Dong Mingfu Shang Clinical Efficacy of Controlled-Release Morphine Tablets Combined with Celecoxib in Pain Management and the Effects on WNK1 Expression Clinics Controlled-release Morphine Tablets Celecoxib Osteocarcinoma-Related Pain Clinical Efficacy WNK1 |
| title | Clinical Efficacy of Controlled-Release Morphine Tablets Combined with Celecoxib in Pain Management and the Effects on WNK1 Expression |
| title_full | Clinical Efficacy of Controlled-Release Morphine Tablets Combined with Celecoxib in Pain Management and the Effects on WNK1 Expression |
| title_fullStr | Clinical Efficacy of Controlled-Release Morphine Tablets Combined with Celecoxib in Pain Management and the Effects on WNK1 Expression |
| title_full_unstemmed | Clinical Efficacy of Controlled-Release Morphine Tablets Combined with Celecoxib in Pain Management and the Effects on WNK1 Expression |
| title_short | Clinical Efficacy of Controlled-Release Morphine Tablets Combined with Celecoxib in Pain Management and the Effects on WNK1 Expression |
| title_sort | clinical efficacy of controlled release morphine tablets combined with celecoxib in pain management and the effects on wnk1 expression |
| topic | Controlled-release Morphine Tablets Celecoxib Osteocarcinoma-Related Pain Clinical Efficacy WNK1 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100203&tlng=en |
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