Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays
The common variants in the fat mass- and obesity-associated (FTO) gene have been previously found to be associated with obesity in various adult populations. The objective of the present study was to investigate whether the single nucleotide polymorphisms (SNPs) and linkage disequilibrium (LD) block...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2012-12-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200003 |
| _version_ | 1818766531603988480 |
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| author | Y.D. Apalasamy M.F. Ming S. Rampal A. Bulgiba Z. Mohamed |
| author_facet | Y.D. Apalasamy M.F. Ming S. Rampal A. Bulgiba Z. Mohamed |
| author_sort | Y.D. Apalasamy |
| collection | DOAJ |
| description | The common variants in the fat mass- and obesity-associated (FTO) gene have been previously found to be associated with obesity in various adult populations. The objective of the present study was to investigate whether the single nucleotide polymorphisms (SNPs) and linkage disequilibrium (LD) blocks in various regions of the FTO gene are associated with predisposition to obesity in Malaysian Malays. Thirty-one FTO SNPs were genotyped in 587 (158 obese and 429 non-obese) Malaysian Malay subjects. Obesity traits and lipid profiles were measured and single-marker association testing, LD testing, and haplotype association analysis were performed. LD analysis of the FTO SNPs revealed the presence of 57 regions with complete LD (D’ = 1.0). In addition, we detected the association of rs17817288 with low-density lipoprotein cholesterol. The FTO gene may therefore be involved in lipid metabolism in Malaysian Malays. Two haplotype blocks were present in this region of the FTO gene, but no particular haplotype was found to be significantly associated with an increased risk of obesity in Malaysian Malays. |
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| format | Article |
| id | doaj.art-0630e594848440019c750f729bfac0b1 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-18T08:35:28Z |
| publishDate | 2012-12-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-0630e594848440019c750f729bfac0b12022-12-21T21:14:20ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2012-12-01451211191126Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian MalaysY.D. ApalasamyM.F. MingS. RampalA. BulgibaZ. MohamedThe common variants in the fat mass- and obesity-associated (FTO) gene have been previously found to be associated with obesity in various adult populations. The objective of the present study was to investigate whether the single nucleotide polymorphisms (SNPs) and linkage disequilibrium (LD) blocks in various regions of the FTO gene are associated with predisposition to obesity in Malaysian Malays. Thirty-one FTO SNPs were genotyped in 587 (158 obese and 429 non-obese) Malaysian Malay subjects. Obesity traits and lipid profiles were measured and single-marker association testing, LD testing, and haplotype association analysis were performed. LD analysis of the FTO SNPs revealed the presence of 57 regions with complete LD (D’ = 1.0). In addition, we detected the association of rs17817288 with low-density lipoprotein cholesterol. The FTO gene may therefore be involved in lipid metabolism in Malaysian Malays. Two haplotype blocks were present in this region of the FTO gene, but no particular haplotype was found to be significantly associated with an increased risk of obesity in Malaysian Malays.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200003FTO geneSNPObesityLinkage disequilibriumHaplotypes |
| spellingShingle | Y.D. Apalasamy M.F. Ming S. Rampal A. Bulgiba Z. Mohamed Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays Brazilian Journal of Medical and Biological Research FTO gene SNP Obesity Linkage disequilibrium Haplotypes |
| title | Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays |
| title_full | Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays |
| title_fullStr | Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays |
| title_full_unstemmed | Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays |
| title_short | Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays |
| title_sort | genetic association of snps in the fto gene and predisposition to obesity in malaysian malays |
| topic | FTO gene SNP Obesity Linkage disequilibrium Haplotypes |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200003 |
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