Ceria nanoparticles boost activity of aged murine oocytes
Oocyte meiotic maturation and viability of follicular granulosa cells in young and old experimental Balb/C and CBA mice in the presence of ceria nanoparticles were studied. Treatment of old Balb/c mice with ceria nanoparticles for three days once a day (at a dose of 45 mg/kg) leads to a positive eff...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2012-12-01
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| Series: | Nano Biomedicine and Engineering |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.5101/nbe.v4i4.p188-194 |
| _version_ | 1797673415862124544 |
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| author | NYa Spivak EA Shepel NM Zholobak AB Shcherbakov GV Antonovitch RI Yanchiy VK Ivanov YuD Tretyakov |
| author_facet | NYa Spivak EA Shepel NM Zholobak AB Shcherbakov GV Antonovitch RI Yanchiy VK Ivanov YuD Tretyakov |
| author_sort | NYa Spivak |
| collection | DOAJ |
| description | Oocyte meiotic maturation and viability of follicular granulosa cells in young and old experimental Balb/C and CBA mice in the presence of ceria nanoparticles were studied. Treatment of old Balb/c mice with ceria nanoparticles for three days once a day (at a dose of 45 mg/kg) leads to a positive effect on reproductive system. The number of oocytes in follicles increases and this effect is accompanied by an increase in the number of oocytes at metaphase Ⅰ and metaphase Ⅱ. The number of living granulosa cells increases, while percentage of the necrotic and apoptotic ones decreases relative to control group. Data obtained on CBA mice provided additional evidence for positive effect of ceria nanoparticles. Depending on the initial state of the reproductive system and dose of ceria nanoparticles the effectiveness of the treatment will vary. In case of old mice ceria nanoparticles protect ovarian cells against oxidative damage, working as anti-aging agent. The litter size in old mice treated with the CNs increases too. |
| first_indexed | 2024-03-11T21:45:11Z |
| format | Article |
| id | doaj.art-063157e4a73b47edadf08e4a41d1ea74 |
| institution | Directory Open Access Journal |
| issn | 2150-5578 |
| language | English |
| last_indexed | 2024-03-11T21:45:11Z |
| publishDate | 2012-12-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Nano Biomedicine and Engineering |
| spelling | doaj.art-063157e4a73b47edadf08e4a41d1ea742023-09-26T10:12:43ZengTsinghua University PressNano Biomedicine and Engineering2150-55782012-12-014418819410.5101/nbe.v4i4.p188-194Ceria nanoparticles boost activity of aged murine oocytesNYa Spivak0EA Shepel1NM Zholobak2AB Shcherbakov3GV Antonovitch4RI Yanchiy5VK Ivanov6YuD Tretyakov7Zabolotny Institute of Microbiology and Virology, NAS of Ukraine, Zabolotnogo str. 154, Kiev, D 03680, UkraineBogomoletz Institute of Physiology, NAS of Ukraine, Bogomoletz str. 4, Kiev, 01024, UkraineZabolotny Institute of Microbiology and Virology, NAS of Ukraine, Zabolotnogo str. 154, Kiev, D 03680, UkraineZabolotny Institute of Microbiology and Virology, NAS of Ukraine, Zabolotnogo str. 154, Kiev, D 03680, UkraineZabolotny Institute of Microbiology and Virology, NAS of Ukraine, Zabolotnogo str. 154, Kiev, D 03680, UkraineBogomoletz Institute of Physiology, NAS of Ukraine, Bogomoletz str. 4, Kiev, 01024, UkraineKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii pr. 31, Moscow, 119991, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii pr. 31, Moscow, 119991, RussiaOocyte meiotic maturation and viability of follicular granulosa cells in young and old experimental Balb/C and CBA mice in the presence of ceria nanoparticles were studied. Treatment of old Balb/c mice with ceria nanoparticles for three days once a day (at a dose of 45 mg/kg) leads to a positive effect on reproductive system. The number of oocytes in follicles increases and this effect is accompanied by an increase in the number of oocytes at metaphase Ⅰ and metaphase Ⅱ. The number of living granulosa cells increases, while percentage of the necrotic and apoptotic ones decreases relative to control group. Data obtained on CBA mice provided additional evidence for positive effect of ceria nanoparticles. Depending on the initial state of the reproductive system and dose of ceria nanoparticles the effectiveness of the treatment will vary. In case of old mice ceria nanoparticles protect ovarian cells against oxidative damage, working as anti-aging agent. The litter size in old mice treated with the CNs increases too.https://www.sciopen.com/article/10.5101/nbe.v4i4.p188-194ceriananoparticleantioxidantsoocyte meiotic maturationgranulosa cell viability |
| spellingShingle | NYa Spivak EA Shepel NM Zholobak AB Shcherbakov GV Antonovitch RI Yanchiy VK Ivanov YuD Tretyakov Ceria nanoparticles boost activity of aged murine oocytes Nano Biomedicine and Engineering ceria nanoparticle antioxidants oocyte meiotic maturation granulosa cell viability |
| title | Ceria nanoparticles boost activity of aged murine oocytes |
| title_full | Ceria nanoparticles boost activity of aged murine oocytes |
| title_fullStr | Ceria nanoparticles boost activity of aged murine oocytes |
| title_full_unstemmed | Ceria nanoparticles boost activity of aged murine oocytes |
| title_short | Ceria nanoparticles boost activity of aged murine oocytes |
| title_sort | ceria nanoparticles boost activity of aged murine oocytes |
| topic | ceria nanoparticle antioxidants oocyte meiotic maturation granulosa cell viability |
| url | https://www.sciopen.com/article/10.5101/nbe.v4i4.p188-194 |
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