Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report
Abstract Background Breast cancer infrequently metastasizes to the sternum as solitary metastasis. We experienced successful treatment with proton beam therapy for a case of sternal metastasis of breast cancer. This case demonstrates for the first time the role of proton therapy in the treatment of...
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-022-03335-5 |
| _version_ | 1818773599430901760 |
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| author | Yojiro Ishikawa Motohisa Suzuki Hisashi Yamaguchi Ichiro Seto Masanori Machida Yoshiaki Takagawa Keiichi Jingu Yasuyuki Kikuchi Masao Murakami |
| author_facet | Yojiro Ishikawa Motohisa Suzuki Hisashi Yamaguchi Ichiro Seto Masanori Machida Yoshiaki Takagawa Keiichi Jingu Yasuyuki Kikuchi Masao Murakami |
| author_sort | Yojiro Ishikawa |
| collection | DOAJ |
| description | Abstract Background Breast cancer infrequently metastasizes to the sternum as solitary metastasis. We experienced successful treatment with proton beam therapy for a case of sternal metastasis of breast cancer. This case demonstrates for the first time the role of proton therapy in the treatment of oligometastatic sternal metastasis with limited tolerance of normal tissue due to previous photon irradiation. Case presentation A 40-year-old Japanese female presented with lumpiness in her left breast. The patient was diagnosed with breast cancer (cT1N0M0, cStage IA) and underwent partial mastectomy with axillary lymph node dissection. After the mastectomy, the patient received radiation therapy with 50 Gy in 25 fractions for initial irradiation of the left breast. After the initial irradiation of 50 Gy, the patient received 10 Gy in five fractions of a sequential boost for the tumor bed to a total dose of 60 Gy. Although the patient was administered tamoxifen after radiation therapy, solitary sternal metastasis occurred 6 months after radiation therapy. She refused chemotherapy and requested proton beam therapy for her sternal metastasis. The daily proton beam therapy fractions were 2.5 relative biological effectiveness, receiving a total dose of 70 Gy relative biological effectiveness. An acute side effect of grade 2 dermatitis according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. occurred during proton beam therapy, but there was no acute or late complication of more than grade 3. At 3 years after proton beam therapy, the patient remains in complete remission without surgery or chemotherapy. Discussion and conclusion Proton beam therapy for solitary sternal metastasis of breast cancer is considered to be a therapeutic option. |
| first_indexed | 2024-12-18T10:27:49Z |
| format | Article |
| id | doaj.art-0631953145d247e3bfc610de2a5441e4 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-18T10:27:49Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-0631953145d247e3bfc610de2a5441e42022-12-21T21:10:56ZengBMCJournal of Medical Case Reports1752-19472022-03-011611810.1186/s13256-022-03335-5Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case reportYojiro Ishikawa0Motohisa Suzuki1Hisashi Yamaguchi2Ichiro Seto3Masanori Machida4Yoshiaki Takagawa5Keiichi Jingu6Yasuyuki Kikuchi7Masao Murakami8Department of Radiation Oncology, Southern Tohoku Proton Therapy CenterDepartment of Radiation Oncology, Southern Tohoku Proton Therapy CenterDepartment of Radiation Oncology, Southern Tohoku Proton Therapy CenterDepartment of Radiation Oncology, Southern Tohoku Proton Therapy CenterDepartment of Radiation Oncology, Southern Tohoku Proton Therapy CenterDepartment of Radiation Oncology, Southern Tohoku Proton Therapy CenterDepartment of Radiation Oncology, Tohoku University Graduate School of MedicineDepartment of Radiation Oncology, Southern Tohoku Proton Therapy CenterDepartment of Radiation Oncology, Southern Tohoku Proton Therapy CenterAbstract Background Breast cancer infrequently metastasizes to the sternum as solitary metastasis. We experienced successful treatment with proton beam therapy for a case of sternal metastasis of breast cancer. This case demonstrates for the first time the role of proton therapy in the treatment of oligometastatic sternal metastasis with limited tolerance of normal tissue due to previous photon irradiation. Case presentation A 40-year-old Japanese female presented with lumpiness in her left breast. The patient was diagnosed with breast cancer (cT1N0M0, cStage IA) and underwent partial mastectomy with axillary lymph node dissection. After the mastectomy, the patient received radiation therapy with 50 Gy in 25 fractions for initial irradiation of the left breast. After the initial irradiation of 50 Gy, the patient received 10 Gy in five fractions of a sequential boost for the tumor bed to a total dose of 60 Gy. Although the patient was administered tamoxifen after radiation therapy, solitary sternal metastasis occurred 6 months after radiation therapy. She refused chemotherapy and requested proton beam therapy for her sternal metastasis. The daily proton beam therapy fractions were 2.5 relative biological effectiveness, receiving a total dose of 70 Gy relative biological effectiveness. An acute side effect of grade 2 dermatitis according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. occurred during proton beam therapy, but there was no acute or late complication of more than grade 3. At 3 years after proton beam therapy, the patient remains in complete remission without surgery or chemotherapy. Discussion and conclusion Proton beam therapy for solitary sternal metastasis of breast cancer is considered to be a therapeutic option.https://doi.org/10.1186/s13256-022-03335-5Proton beam therapyBreast cancerSternal metastasis |
| spellingShingle | Yojiro Ishikawa Motohisa Suzuki Hisashi Yamaguchi Ichiro Seto Masanori Machida Yoshiaki Takagawa Keiichi Jingu Yasuyuki Kikuchi Masao Murakami Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report Journal of Medical Case Reports Proton beam therapy Breast cancer Sternal metastasis |
| title | Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report |
| title_full | Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report |
| title_fullStr | Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report |
| title_full_unstemmed | Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report |
| title_short | Successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer: a case report |
| title_sort | successful treatment with proton beam therapy for a solitary sternal metastasis of breast cancer a case report |
| topic | Proton beam therapy Breast cancer Sternal metastasis |
| url | https://doi.org/10.1186/s13256-022-03335-5 |
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