ABOUT EXPANDING OPTIONS FOR USING BALB/C NUDE MICE FOR EXPERIMENTAL STUDY OF HUMAN MALIGNANT TUMORS IN VIVO
The article has a problematic scripting nature. At the present stage, in addition to objective factors that make it difficult to create adequate experimental models of human oncogenesis, there is a significant backlog of domestic science in the development of this direction. This reduces the availab...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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ANO "Perspective of oncology"
2020-06-01
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| Series: | Южно-Российский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.cancersp.com/jour/article/view/55 |
| _version_ | 1797882851665903616 |
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| author | G. V. Zhukova A. I. Shikhliarova A. B. Sagakyants T. P. Protasova |
| author_facet | G. V. Zhukova A. I. Shikhliarova A. B. Sagakyants T. P. Protasova |
| author_sort | G. V. Zhukova |
| collection | DOAJ |
| description | The article has a problematic scripting nature. At the present stage, in addition to objective factors that make it difficult to create adequate experimental models of human oncogenesis, there is a significant backlog of domestic science in the development of this direction. This reduces the availability for Russian specialists of humanized immunodeficient animals corresponding to the level of research tasks. Based on the analysis of literature data, we discuss approaches that can expand the use of a widely available immunodeficiency animal model‑BALB/c nude mice. The possibility of using human mesenchymal stem cells that are not rejected by BALB/C Nude mice for local humanization of immunodeficient animals and improving the structural and functional characteristics of xenografts is considered. The possibility of obtaining xenografts of human glioblasts supported in the body of immunocompetent BALB/c mice after serial passages of organotypic tumor spheroids in the brain of BALB/c nude mice is analyzed. |
| first_indexed | 2024-04-10T03:42:15Z |
| format | Article |
| id | doaj.art-0633335c3a6e43c1ac6654e5a52a1a7f |
| institution | Directory Open Access Journal |
| issn | 2686-9039 |
| language | Russian |
| last_indexed | 2024-04-10T03:42:15Z |
| publishDate | 2020-06-01 |
| publisher | ANO "Perspective of oncology" |
| record_format | Article |
| series | Южно-Российский онкологический журнал |
| spelling | doaj.art-0633335c3a6e43c1ac6654e5a52a1a7f2023-03-13T07:19:28ZrusANO "Perspective of oncology"Южно-Российский онкологический журнал2686-90392020-06-0112283510.37748/2687-0533-2020-1-2-411ABOUT EXPANDING OPTIONS FOR USING BALB/C NUDE MICE FOR EXPERIMENTAL STUDY OF HUMAN MALIGNANT TUMORS IN VIVOG. V. Zhukova0A. I. Shikhliarova1A. B. Sagakyants2T. P. Protasova3ФГБУ «НМИЦ онкологии» Минздрава РоссииФГБУ «НМИЦ онкологии» Минздрава РоссииФГБУ «НМИЦ онкологии» Минздрава РоссииФГБУ «НМИЦ онкологии» Минздрава РоссииThe article has a problematic scripting nature. At the present stage, in addition to objective factors that make it difficult to create adequate experimental models of human oncogenesis, there is a significant backlog of domestic science in the development of this direction. This reduces the availability for Russian specialists of humanized immunodeficient animals corresponding to the level of research tasks. Based on the analysis of literature data, we discuss approaches that can expand the use of a widely available immunodeficiency animal model‑BALB/c nude mice. The possibility of using human mesenchymal stem cells that are not rejected by BALB/C Nude mice for local humanization of immunodeficient animals and improving the structural and functional characteristics of xenografts is considered. The possibility of obtaining xenografts of human glioblasts supported in the body of immunocompetent BALB/c mice after serial passages of organotypic tumor spheroids in the brain of BALB/c nude mice is analyzed.https://www.cancersp.com/jour/article/view/55ксенографты злокачественных опухолей человекамыши balb/c nudeметоды гуманизациимезенхимальные стволовые клеткииммунокомпетентные животныесибсы |
| spellingShingle | G. V. Zhukova A. I. Shikhliarova A. B. Sagakyants T. P. Protasova ABOUT EXPANDING OPTIONS FOR USING BALB/C NUDE MICE FOR EXPERIMENTAL STUDY OF HUMAN MALIGNANT TUMORS IN VIVO Южно-Российский онкологический журнал ксенографты злокачественных опухолей человека мыши balb/c nude методы гуманизации мезенхимальные стволовые клетки иммунокомпетентные животные сибсы |
| title | ABOUT EXPANDING OPTIONS FOR USING BALB/C NUDE MICE FOR EXPERIMENTAL STUDY OF HUMAN MALIGNANT TUMORS IN VIVO |
| title_full | ABOUT EXPANDING OPTIONS FOR USING BALB/C NUDE MICE FOR EXPERIMENTAL STUDY OF HUMAN MALIGNANT TUMORS IN VIVO |
| title_fullStr | ABOUT EXPANDING OPTIONS FOR USING BALB/C NUDE MICE FOR EXPERIMENTAL STUDY OF HUMAN MALIGNANT TUMORS IN VIVO |
| title_full_unstemmed | ABOUT EXPANDING OPTIONS FOR USING BALB/C NUDE MICE FOR EXPERIMENTAL STUDY OF HUMAN MALIGNANT TUMORS IN VIVO |
| title_short | ABOUT EXPANDING OPTIONS FOR USING BALB/C NUDE MICE FOR EXPERIMENTAL STUDY OF HUMAN MALIGNANT TUMORS IN VIVO |
| title_sort | about expanding options for using balb c nude mice for experimental study of human malignant tumors in vivo |
| topic | ксенографты злокачественных опухолей человека мыши balb/c nude методы гуманизации мезенхимальные стволовые клетки иммунокомпетентные животные сибсы |
| url | https://www.cancersp.com/jour/article/view/55 |
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