Identification of Five Ferroptosis-Related LncRNAs as Novel Prognosis and Diagnosis Signatures for Renal Cancer
Background: Ferroptosis is a novel regulated cell death that is characterized by iron-dependent oxidative damage. Renal cancer is the second most common cancer of the urinary system, which is highly correlated with iron metabolism. The aim of our present study was to identify suitable ferroptosis-re...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-01-01
|
| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.763697/full |
| _version_ | 1818988210114527232 |
|---|---|
| author | Xiangjun Shu Xiangjun Shu Zaiqi Zhang Zhi-Yong Yao Xiao-Liang Xing Xiao-Liang Xing |
| author_facet | Xiangjun Shu Xiangjun Shu Zaiqi Zhang Zhi-Yong Yao Xiao-Liang Xing Xiao-Liang Xing |
| author_sort | Xiangjun Shu |
| collection | DOAJ |
| description | Background: Ferroptosis is a novel regulated cell death that is characterized by iron-dependent oxidative damage. Renal cancer is the second most common cancer of the urinary system, which is highly correlated with iron metabolism. The aim of our present study was to identify suitable ferroptosis-related prognosis signatures for renal cancer.Methods: We downloaded the RNA-seq count data of renal cancer from The Cancer Genome Atlas database and used the DESeq2, Survival, and Cox regression analyses to screen the prognosis signatures.Results: We identified 5 ferroptosis-related differentially expressed lncRNAs (FR-DELs) (DOCK8-AS1, SNHG17, RUSC1-AS1, LINC02609, and LUCAT1) to be independently correlated with the overall survival (OS) of patients with renal cancer. The risk assessment model and diagnosis model constructed by those 5 FR-DELs could well predict the outcome and the diagnosis of renal cancer.Conclusion: Our present study not only suggested those 5 FR-DELs could be used as prognosis and diagnosis signatures for renal cancer but also provided strategies for other cancers in the screening of ferroptosis-related biomarkers. |
| first_indexed | 2024-12-20T19:18:57Z |
| format | Article |
| id | doaj.art-06341c888165440b839368fa4a077183 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-20T19:18:57Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-06341c888165440b839368fa4a0771832022-12-21T19:29:03ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-01-01810.3389/fmolb.2021.763697763697Identification of Five Ferroptosis-Related LncRNAs as Novel Prognosis and Diagnosis Signatures for Renal CancerXiangjun Shu0Xiangjun Shu1Zaiqi Zhang2Zhi-Yong Yao3Xiao-Liang Xing4Xiao-Liang Xing5School of Public Health and Laboratory Medicine, Hunan University of Medicine, Huaihua, ChinaThe First Affiliated Hospital, Hunan University of Medicine, Huaihua, ChinaThe First Affiliated Hospital, Hunan University of Medicine, Huaihua, ChinaThe First Affiliated Hospital, Hunan University of Medicine, Huaihua, ChinaSchool of Public Health and Laboratory Medicine, Hunan University of Medicine, Huaihua, ChinaThe First Affiliated Hospital, Hunan University of Medicine, Huaihua, ChinaBackground: Ferroptosis is a novel regulated cell death that is characterized by iron-dependent oxidative damage. Renal cancer is the second most common cancer of the urinary system, which is highly correlated with iron metabolism. The aim of our present study was to identify suitable ferroptosis-related prognosis signatures for renal cancer.Methods: We downloaded the RNA-seq count data of renal cancer from The Cancer Genome Atlas database and used the DESeq2, Survival, and Cox regression analyses to screen the prognosis signatures.Results: We identified 5 ferroptosis-related differentially expressed lncRNAs (FR-DELs) (DOCK8-AS1, SNHG17, RUSC1-AS1, LINC02609, and LUCAT1) to be independently correlated with the overall survival (OS) of patients with renal cancer. The risk assessment model and diagnosis model constructed by those 5 FR-DELs could well predict the outcome and the diagnosis of renal cancer.Conclusion: Our present study not only suggested those 5 FR-DELs could be used as prognosis and diagnosis signatures for renal cancer but also provided strategies for other cancers in the screening of ferroptosis-related biomarkers.https://www.frontiersin.org/articles/10.3389/fmolb.2021.763697/fullrenal cancerferroptosisdifferentially expressed lncRNAsprognosisdiagnosis |
| spellingShingle | Xiangjun Shu Xiangjun Shu Zaiqi Zhang Zhi-Yong Yao Xiao-Liang Xing Xiao-Liang Xing Identification of Five Ferroptosis-Related LncRNAs as Novel Prognosis and Diagnosis Signatures for Renal Cancer Frontiers in Molecular Biosciences renal cancer ferroptosis differentially expressed lncRNAs prognosis diagnosis |
| title | Identification of Five Ferroptosis-Related LncRNAs as Novel Prognosis and Diagnosis Signatures for Renal Cancer |
| title_full | Identification of Five Ferroptosis-Related LncRNAs as Novel Prognosis and Diagnosis Signatures for Renal Cancer |
| title_fullStr | Identification of Five Ferroptosis-Related LncRNAs as Novel Prognosis and Diagnosis Signatures for Renal Cancer |
| title_full_unstemmed | Identification of Five Ferroptosis-Related LncRNAs as Novel Prognosis and Diagnosis Signatures for Renal Cancer |
| title_short | Identification of Five Ferroptosis-Related LncRNAs as Novel Prognosis and Diagnosis Signatures for Renal Cancer |
| title_sort | identification of five ferroptosis related lncrnas as novel prognosis and diagnosis signatures for renal cancer |
| topic | renal cancer ferroptosis differentially expressed lncRNAs prognosis diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.763697/full |
| work_keys_str_mv | AT xiangjunshu identificationoffiveferroptosisrelatedlncrnasasnovelprognosisanddiagnosissignaturesforrenalcancer AT xiangjunshu identificationoffiveferroptosisrelatedlncrnasasnovelprognosisanddiagnosissignaturesforrenalcancer AT zaiqizhang identificationoffiveferroptosisrelatedlncrnasasnovelprognosisanddiagnosissignaturesforrenalcancer AT zhiyongyao identificationoffiveferroptosisrelatedlncrnasasnovelprognosisanddiagnosissignaturesforrenalcancer AT xiaoliangxing identificationoffiveferroptosisrelatedlncrnasasnovelprognosisanddiagnosissignaturesforrenalcancer AT xiaoliangxing identificationoffiveferroptosisrelatedlncrnasasnovelprognosisanddiagnosissignaturesforrenalcancer |