Reprogramming the Circadian Dynamics of Epileptic Genes in Mouse Temporal Lobe Epilepsy
Temporal lobe epilepsy (TLE) is a common and severe epilepsy displaying rhythmicity in humans and animals. However, how the circadian clock contributes to TLE remains elusive. A recent circadian analysis of the ventral hippocampal transcriptome of pilocarpine-induced TLE mice revealed as many as 165...
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/7/6400 |
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| author | Sha Sun Han Wang |
| author_facet | Sha Sun Han Wang |
| author_sort | Sha Sun |
| collection | DOAJ |
| description | Temporal lobe epilepsy (TLE) is a common and severe epilepsy displaying rhythmicity in humans and animals. However, how the circadian clock contributes to TLE remains elusive. A recent circadian analysis of the ventral hippocampal transcriptome of pilocarpine-induced TLE mice revealed as many as 1650 rhythmically expressed transcripts. Here, a comparison of the mouse ventral hippocampal transcriptome with the human epilepsy-related gene set identified 315 possible mouse epilepsy-related genes. Rhythmicity analysis classified them into arrhythmicity, loss-of-rhythmicity, gain-of-rhythmicity, and rhythmicity-maintaining groups. KEGG and GO analyses of these mouse epilepsy genes suggest their involvement in circadian entrainment. In TLE mice, <i>Htr1d</i>, <i>Drd2</i>, and <i>Chrna3</i> lose rhythmicity, but <i>P2rx7</i> gains rhythmicity; the up-regulation of <i>Htr1d</i> and <i>Drd2</i> and down-regulation of <i>Chrna3</i> inhibit adenylate cyclase (AC), and up-regulation of <i>Htr1d</i>, <i>Drd2</i>, and <i>P2rx7</i> activates protein kinase C (PKC). Together, these results suggest that epilepsy can disrupt the circadian dynamics of the epileptic genes, shed light on possible TLE pathogenesis, and provide potential targets for TLE diagnosis and chronotherapy. |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T05:34:30Z |
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| spelling | doaj.art-0634f434c113414f8decba1e1c7a19ea2023-11-17T16:50:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01247640010.3390/ijms24076400Reprogramming the Circadian Dynamics of Epileptic Genes in Mouse Temporal Lobe EpilepsySha Sun0Han Wang1Center for Circadian Clocks, Soochow University, Suzhou 215123, ChinaCenter for Circadian Clocks, Soochow University, Suzhou 215123, ChinaTemporal lobe epilepsy (TLE) is a common and severe epilepsy displaying rhythmicity in humans and animals. However, how the circadian clock contributes to TLE remains elusive. A recent circadian analysis of the ventral hippocampal transcriptome of pilocarpine-induced TLE mice revealed as many as 1650 rhythmically expressed transcripts. Here, a comparison of the mouse ventral hippocampal transcriptome with the human epilepsy-related gene set identified 315 possible mouse epilepsy-related genes. Rhythmicity analysis classified them into arrhythmicity, loss-of-rhythmicity, gain-of-rhythmicity, and rhythmicity-maintaining groups. KEGG and GO analyses of these mouse epilepsy genes suggest their involvement in circadian entrainment. In TLE mice, <i>Htr1d</i>, <i>Drd2</i>, and <i>Chrna3</i> lose rhythmicity, but <i>P2rx7</i> gains rhythmicity; the up-regulation of <i>Htr1d</i> and <i>Drd2</i> and down-regulation of <i>Chrna3</i> inhibit adenylate cyclase (AC), and up-regulation of <i>Htr1d</i>, <i>Drd2</i>, and <i>P2rx7</i> activates protein kinase C (PKC). Together, these results suggest that epilepsy can disrupt the circadian dynamics of the epileptic genes, shed light on possible TLE pathogenesis, and provide potential targets for TLE diagnosis and chronotherapy.https://www.mdpi.com/1422-0067/24/7/6400temporal lobe epilepsyepileptic genesrhythmicitycircadian clockschronotherapy |
| spellingShingle | Sha Sun Han Wang Reprogramming the Circadian Dynamics of Epileptic Genes in Mouse Temporal Lobe Epilepsy International Journal of Molecular Sciences temporal lobe epilepsy epileptic genes rhythmicity circadian clocks chronotherapy |
| title | Reprogramming the Circadian Dynamics of Epileptic Genes in Mouse Temporal Lobe Epilepsy |
| title_full | Reprogramming the Circadian Dynamics of Epileptic Genes in Mouse Temporal Lobe Epilepsy |
| title_fullStr | Reprogramming the Circadian Dynamics of Epileptic Genes in Mouse Temporal Lobe Epilepsy |
| title_full_unstemmed | Reprogramming the Circadian Dynamics of Epileptic Genes in Mouse Temporal Lobe Epilepsy |
| title_short | Reprogramming the Circadian Dynamics of Epileptic Genes in Mouse Temporal Lobe Epilepsy |
| title_sort | reprogramming the circadian dynamics of epileptic genes in mouse temporal lobe epilepsy |
| topic | temporal lobe epilepsy epileptic genes rhythmicity circadian clocks chronotherapy |
| url | https://www.mdpi.com/1422-0067/24/7/6400 |
| work_keys_str_mv | AT shasun reprogrammingthecircadiandynamicsofepilepticgenesinmousetemporallobeepilepsy AT hanwang reprogrammingthecircadiandynamicsofepilepticgenesinmousetemporallobeepilepsy |