Proteolytic Landscapes in Gastric Pathology and Cancerogenesis
Gastric cancer is a leading cause of cancer-related death, and a large proportion of cases are inseparably linked to infections with the bacterial pathogen and type I carcinogen <i>Helicobacter pylori</i>. The development of gastric cancer follows a cascade of transformative tissue event...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/5/2419 |
| _version_ | 1797475041942700032 |
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| author | Sabine Bernegger Miroslaw Jarzab Silja Wessler Gernot Posselt |
| author_facet | Sabine Bernegger Miroslaw Jarzab Silja Wessler Gernot Posselt |
| author_sort | Sabine Bernegger |
| collection | DOAJ |
| description | Gastric cancer is a leading cause of cancer-related death, and a large proportion of cases are inseparably linked to infections with the bacterial pathogen and type I carcinogen <i>Helicobacter pylori</i>. The development of gastric cancer follows a cascade of transformative tissue events in an inflammatory environment. Proteases of host origin as well as <i>H. pylori</i>-derived proteases contribute to disease progression at every stage, from chronic gastritis to gastric cancer. In the present article, we discuss the importance of (metallo-)proteases in colonization, epithelial inflammation, and barrier disruption in tissue transformation, deregulation of cell proliferation and cell death, as well as tumor metastasis and neoangiogenesis. Proteases of the matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase domain-containing protein (ADAM) families, caspases, calpain, and the <i>H. pylori</i> proteases HtrA, Hp1012, and Hp0169 cleave substrates including extracellular matrix molecules, chemokines, and cytokines, as well as their cognate receptors, and thus shape the pathogenic microenvironment. This review aims to summarize the current understanding of how proteases contribute to disease progression in the gastric compartment. |
| first_indexed | 2024-03-09T20:38:30Z |
| format | Article |
| id | doaj.art-0634f7cca7a94f62ba7a40627af47115 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T20:38:30Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0634f7cca7a94f62ba7a40627af471152023-11-23T23:03:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-02-01235241910.3390/ijms23052419Proteolytic Landscapes in Gastric Pathology and CancerogenesisSabine Bernegger0Miroslaw Jarzab1Silja Wessler2Gernot Posselt3Division of Microbiology, Department of Biosciences and Medical Biology, Paris Lodron University of Salzburg, Hellbrunner Strasse 34, 5020 Salzburg, AustriaDivision of Microbiology, Department of Biosciences and Medical Biology, Paris Lodron University of Salzburg, Hellbrunner Strasse 34, 5020 Salzburg, AustriaDivision of Microbiology, Department of Biosciences and Medical Biology, Paris Lodron University of Salzburg, Hellbrunner Strasse 34, 5020 Salzburg, AustriaDivision of Microbiology, Department of Biosciences and Medical Biology, Paris Lodron University of Salzburg, Hellbrunner Strasse 34, 5020 Salzburg, AustriaGastric cancer is a leading cause of cancer-related death, and a large proportion of cases are inseparably linked to infections with the bacterial pathogen and type I carcinogen <i>Helicobacter pylori</i>. The development of gastric cancer follows a cascade of transformative tissue events in an inflammatory environment. Proteases of host origin as well as <i>H. pylori</i>-derived proteases contribute to disease progression at every stage, from chronic gastritis to gastric cancer. In the present article, we discuss the importance of (metallo-)proteases in colonization, epithelial inflammation, and barrier disruption in tissue transformation, deregulation of cell proliferation and cell death, as well as tumor metastasis and neoangiogenesis. Proteases of the matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase domain-containing protein (ADAM) families, caspases, calpain, and the <i>H. pylori</i> proteases HtrA, Hp1012, and Hp0169 cleave substrates including extracellular matrix molecules, chemokines, and cytokines, as well as their cognate receptors, and thus shape the pathogenic microenvironment. This review aims to summarize the current understanding of how proteases contribute to disease progression in the gastric compartment.https://www.mdpi.com/1422-0067/23/5/2419gastric cancerproteaseMMPADAMHtrAEMT |
| spellingShingle | Sabine Bernegger Miroslaw Jarzab Silja Wessler Gernot Posselt Proteolytic Landscapes in Gastric Pathology and Cancerogenesis International Journal of Molecular Sciences gastric cancer protease MMP ADAM HtrA EMT |
| title | Proteolytic Landscapes in Gastric Pathology and Cancerogenesis |
| title_full | Proteolytic Landscapes in Gastric Pathology and Cancerogenesis |
| title_fullStr | Proteolytic Landscapes in Gastric Pathology and Cancerogenesis |
| title_full_unstemmed | Proteolytic Landscapes in Gastric Pathology and Cancerogenesis |
| title_short | Proteolytic Landscapes in Gastric Pathology and Cancerogenesis |
| title_sort | proteolytic landscapes in gastric pathology and cancerogenesis |
| topic | gastric cancer protease MMP ADAM HtrA EMT |
| url | https://www.mdpi.com/1422-0067/23/5/2419 |
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