Effects of IMOD™ on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male rats
Objective: Diabetes is associated with vascular complications and impaired angiogenesis. Since angiogenesis plays a crucial role in vascular homeostasis in ischemic heart diseases, in this study, the effect of IMOD™ on miR-503 and CDC25 expression level which are altered in impaired angiogenesis wer...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2018-02-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | http://ajp.mums.ac.ir/article_9682_8369912f1f26b0033094a7442ff8ef61.pdf |
| _version_ | 1811263419432566784 |
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| author | Arshad Ghaffari-Nasab Fariba Mirzaei Bavil Rafigheh Ghiasi Saeed Sadigh-Eteghad Mohammad Reza Alipour |
| author_facet | Arshad Ghaffari-Nasab Fariba Mirzaei Bavil Rafigheh Ghiasi Saeed Sadigh-Eteghad Mohammad Reza Alipour |
| author_sort | Arshad Ghaffari-Nasab |
| collection | DOAJ |
| description | Objective: Diabetes is associated with vascular complications and impaired angiogenesis. Since angiogenesis plays a crucial role in vascular homeostasis in ischemic heart diseases, in this study, the effect of IMOD™ on miR-503 and CDC25 expression level which are altered in impaired angiogenesis were investigated in heart tissue of diabetic rats. Materials and Methods: Forty male Wistar rats (200-250 g) were randomly classified into 4 groups: control (C), IMOD™ (I), diabetes (D), and diabetes+IMOD™ (D+I). For induction of experimental diabetes in animals, a single dose of streptozotocin (STZ; 60mg/kg) was injected intraperitoneally. After 8 weeks of treatment with IMOD™ (20 mg/kg/day), heart tissue samples were removed and used for measurement of miR-503 and CDC25 expression level as well as histological studies. Results: Results of this study showed that diabetes decreased heart tissue angiogenesis which was associated with increased miR-503 and reduced CDC25 expression levels (p |
| first_indexed | 2024-04-12T19:43:48Z |
| format | Article |
| id | doaj.art-0635391378f147aeafa1e46a63d6aae0 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-04-12T19:43:48Z |
| publishDate | 2018-02-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-0635391378f147aeafa1e46a63d6aae02022-12-22T03:19:00ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492018-02-018215216010.22038/ajp.2017.23107.18569682Effects of IMOD™ on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male ratsArshad Ghaffari-Nasab0Fariba Mirzaei Bavil1Rafigheh Ghiasi2Saeed Sadigh-Eteghad3Mohammad Reza Alipour4Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, IranDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IranDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IranNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, IranNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, IranObjective: Diabetes is associated with vascular complications and impaired angiogenesis. Since angiogenesis plays a crucial role in vascular homeostasis in ischemic heart diseases, in this study, the effect of IMOD™ on miR-503 and CDC25 expression level which are altered in impaired angiogenesis were investigated in heart tissue of diabetic rats. Materials and Methods: Forty male Wistar rats (200-250 g) were randomly classified into 4 groups: control (C), IMOD™ (I), diabetes (D), and diabetes+IMOD™ (D+I). For induction of experimental diabetes in animals, a single dose of streptozotocin (STZ; 60mg/kg) was injected intraperitoneally. After 8 weeks of treatment with IMOD™ (20 mg/kg/day), heart tissue samples were removed and used for measurement of miR-503 and CDC25 expression level as well as histological studies. Results: Results of this study showed that diabetes decreased heart tissue angiogenesis which was associated with increased miR-503 and reduced CDC25 expression levels (phttp://ajp.mums.ac.ir/article_9682_8369912f1f26b0033094a7442ff8ef61.pdfDiabetesAngiogenesismiR-503CDC25IMOD |
| spellingShingle | Arshad Ghaffari-Nasab Fariba Mirzaei Bavil Rafigheh Ghiasi Saeed Sadigh-Eteghad Mohammad Reza Alipour Effects of IMOD™ on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male rats Avicenna Journal of Phytomedicine Diabetes Angiogenesis miR-503 CDC25 IMOD |
| title | Effects of IMOD™ on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male rats |
| title_full | Effects of IMOD™ on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male rats |
| title_fullStr | Effects of IMOD™ on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male rats |
| title_full_unstemmed | Effects of IMOD™ on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male rats |
| title_short | Effects of IMOD™ on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male rats |
| title_sort | effects of imod™ on angiogenesis mir 503 and cdc25 expression levels in heart tissue of diabetic male rats |
| topic | Diabetes Angiogenesis miR-503 CDC25 IMOD |
| url | http://ajp.mums.ac.ir/article_9682_8369912f1f26b0033094a7442ff8ef61.pdf |
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