In Vivo Characterisation of Five Strains of Bovine Viral Diarrhoea Virus 1 (Subgenotype 1c)
Bovine viral diarrhoea virus 1 (BVDV-1) is strongly associated with several important diseases of cattle, such as bovine respiratory disease, diarrhoea and haemoragic lesions. To date many subgenotypes have been reported for BVDV-1, currently ranging from subgenotype 1a to subgenotype 1u. While BVDV...
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MDPI AG
2018-01-01
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| Series: | Pathogens |
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| Online Access: | http://www.mdpi.com/2076-0817/7/1/12 |
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| author | Rebecca K. Ambrose Jennifer L. Gravel Margaret A. Commins Elizabeth V. Fowler Timothy J. Mahony |
| author_facet | Rebecca K. Ambrose Jennifer L. Gravel Margaret A. Commins Elizabeth V. Fowler Timothy J. Mahony |
| author_sort | Rebecca K. Ambrose |
| collection | DOAJ |
| description | Bovine viral diarrhoea virus 1 (BVDV-1) is strongly associated with several important diseases of cattle, such as bovine respiratory disease, diarrhoea and haemoragic lesions. To date many subgenotypes have been reported for BVDV-1, currently ranging from subgenotype 1a to subgenotype 1u. While BVDV-1 has a world-wide distribution, the subgenotypes have a more restricted geographical distribution. As an example, BVDV-1 subgenotypes 1a and 1b are frequently detected in North America and Europe, while the subgenotype 1c is rarely detected. In contrast, BVDV-1 subgenotype 1c is by far the most commonly reported in Australia. Despite this, uneven distribution of the biological importance of the subgenotypes remains unclear. The aim of this study was to characterise the in vivo properties of five strains of BVDV-1 subgenotype 1c in cattle infection studies. No overt respiratory signs were reported in any of the infected cattle regardless of strain. Consistent with other subgenotypes, transient pyrexia and leukopenia were commonly identified, while thrombocytopenia was not. The quantity of virus detected in the nasal secretions of transiently infected animals suggested the likelihood of horizontal transmission was very low. Further studies are required to fully understand the variability and importance of the BVDV-1 subgenotype 1c. |
| first_indexed | 2024-04-11T13:58:49Z |
| format | Article |
| id | doaj.art-0638998723814126a622f84864466d6f |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-11T13:58:49Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-0638998723814126a622f84864466d6f2022-12-22T04:20:10ZengMDPI AGPathogens2076-08172018-01-01711210.3390/pathogens7010012pathogens7010012In Vivo Characterisation of Five Strains of Bovine Viral Diarrhoea Virus 1 (Subgenotype 1c)Rebecca K. Ambrose0Jennifer L. Gravel1Margaret A. Commins2Elizabeth V. Fowler3Timothy J. Mahony4Department of Agriculture and Fisheries, Animal Science, Dutton Park 4102, AustraliaDepartment of Agriculture and Fisheries, Animal Science, Dutton Park 4102, AustraliaDepartment of Agriculture and Fisheries, Animal Science, Dutton Park 4102, AustraliaDepartment of Agriculture and Fisheries, Animal Science, Dutton Park 4102, AustraliaQueensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia 4072, AustraliaBovine viral diarrhoea virus 1 (BVDV-1) is strongly associated with several important diseases of cattle, such as bovine respiratory disease, diarrhoea and haemoragic lesions. To date many subgenotypes have been reported for BVDV-1, currently ranging from subgenotype 1a to subgenotype 1u. While BVDV-1 has a world-wide distribution, the subgenotypes have a more restricted geographical distribution. As an example, BVDV-1 subgenotypes 1a and 1b are frequently detected in North America and Europe, while the subgenotype 1c is rarely detected. In contrast, BVDV-1 subgenotype 1c is by far the most commonly reported in Australia. Despite this, uneven distribution of the biological importance of the subgenotypes remains unclear. The aim of this study was to characterise the in vivo properties of five strains of BVDV-1 subgenotype 1c in cattle infection studies. No overt respiratory signs were reported in any of the infected cattle regardless of strain. Consistent with other subgenotypes, transient pyrexia and leukopenia were commonly identified, while thrombocytopenia was not. The quantity of virus detected in the nasal secretions of transiently infected animals suggested the likelihood of horizontal transmission was very low. Further studies are required to fully understand the variability and importance of the BVDV-1 subgenotype 1c.http://www.mdpi.com/2076-0817/7/1/12bovine viral diarrhoea virus 1BVDV-1subgenotype 1cin vivo propertiesinfectionpyrexialeukopenia |
| spellingShingle | Rebecca K. Ambrose Jennifer L. Gravel Margaret A. Commins Elizabeth V. Fowler Timothy J. Mahony In Vivo Characterisation of Five Strains of Bovine Viral Diarrhoea Virus 1 (Subgenotype 1c) Pathogens bovine viral diarrhoea virus 1 BVDV-1 subgenotype 1c in vivo properties infection pyrexia leukopenia |
| title | In Vivo Characterisation of Five Strains of Bovine Viral Diarrhoea Virus 1 (Subgenotype 1c) |
| title_full | In Vivo Characterisation of Five Strains of Bovine Viral Diarrhoea Virus 1 (Subgenotype 1c) |
| title_fullStr | In Vivo Characterisation of Five Strains of Bovine Viral Diarrhoea Virus 1 (Subgenotype 1c) |
| title_full_unstemmed | In Vivo Characterisation of Five Strains of Bovine Viral Diarrhoea Virus 1 (Subgenotype 1c) |
| title_short | In Vivo Characterisation of Five Strains of Bovine Viral Diarrhoea Virus 1 (Subgenotype 1c) |
| title_sort | in vivo characterisation of five strains of bovine viral diarrhoea virus 1 subgenotype 1c |
| topic | bovine viral diarrhoea virus 1 BVDV-1 subgenotype 1c in vivo properties infection pyrexia leukopenia |
| url | http://www.mdpi.com/2076-0817/7/1/12 |
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