Enhanced Bactericidal Effect of Calcinated Mg–Fe Layered Double Hydroxide Films Driven by the Fenton Reaction
Osteogenic and antibacterial abilities are the permanent pursuit of titanium (Ti)-based orthopedic implants. However, it is difficult to strike the right balance between these two properties. It has been proved that an appropriate alkaline microenvironment formed by Ti modified by magnesium–aluminum...
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/1/272 |
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| author | Lei Chen Yijia Yin Linjia Jian Xianglong Han Xuefeng Zhao Donghui Wang |
| author_facet | Lei Chen Yijia Yin Linjia Jian Xianglong Han Xuefeng Zhao Donghui Wang |
| author_sort | Lei Chen |
| collection | DOAJ |
| description | Osteogenic and antibacterial abilities are the permanent pursuit of titanium (Ti)-based orthopedic implants. However, it is difficult to strike the right balance between these two properties. It has been proved that an appropriate alkaline microenvironment formed by Ti modified by magnesium–aluminum layered double hydroxides (Mg–Al LDHs) could achieve the selective killing of bacteria and promote osteogenesis. However, the existence of Al induces biosafety concerns. In this study, iron (Fe), an essential trace element in the human body, was used to substitute Al, and a calcinated Mg–Fe LDH film was constructed on Ti. The results showed that a proper local alkaline environment created by the constructed film could enhance the antibacterial and osteogenic properties of the material. In addition, the introduction of Fe promoted the Fenton reaction and could produce reactive oxygen species in the infection environment, which might further strengthen the in vivo bactericidal effect. |
| first_indexed | 2024-03-11T09:59:29Z |
| format | Article |
| id | doaj.art-063a6d72b8fc4ed7a74d4e2902680774 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:59:29Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-063a6d72b8fc4ed7a74d4e29026807742023-11-16T15:30:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0124127210.3390/ijms24010272Enhanced Bactericidal Effect of Calcinated Mg–Fe Layered Double Hydroxide Films Driven by the Fenton ReactionLei Chen0Yijia Yin1Linjia Jian2Xianglong Han3Xuefeng Zhao4Donghui Wang5School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaSchool of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaSchool of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, ChinaOsteogenic and antibacterial abilities are the permanent pursuit of titanium (Ti)-based orthopedic implants. However, it is difficult to strike the right balance between these two properties. It has been proved that an appropriate alkaline microenvironment formed by Ti modified by magnesium–aluminum layered double hydroxides (Mg–Al LDHs) could achieve the selective killing of bacteria and promote osteogenesis. However, the existence of Al induces biosafety concerns. In this study, iron (Fe), an essential trace element in the human body, was used to substitute Al, and a calcinated Mg–Fe LDH film was constructed on Ti. The results showed that a proper local alkaline environment created by the constructed film could enhance the antibacterial and osteogenic properties of the material. In addition, the introduction of Fe promoted the Fenton reaction and could produce reactive oxygen species in the infection environment, which might further strengthen the in vivo bactericidal effect.https://www.mdpi.com/1422-0067/24/1/272antibacterialosteogenicMg–Fe layered double hydroxidesalkaline microenvironmentFenton reaction |
| spellingShingle | Lei Chen Yijia Yin Linjia Jian Xianglong Han Xuefeng Zhao Donghui Wang Enhanced Bactericidal Effect of Calcinated Mg–Fe Layered Double Hydroxide Films Driven by the Fenton Reaction International Journal of Molecular Sciences antibacterial osteogenic Mg–Fe layered double hydroxides alkaline microenvironment Fenton reaction |
| title | Enhanced Bactericidal Effect of Calcinated Mg–Fe Layered Double Hydroxide Films Driven by the Fenton Reaction |
| title_full | Enhanced Bactericidal Effect of Calcinated Mg–Fe Layered Double Hydroxide Films Driven by the Fenton Reaction |
| title_fullStr | Enhanced Bactericidal Effect of Calcinated Mg–Fe Layered Double Hydroxide Films Driven by the Fenton Reaction |
| title_full_unstemmed | Enhanced Bactericidal Effect of Calcinated Mg–Fe Layered Double Hydroxide Films Driven by the Fenton Reaction |
| title_short | Enhanced Bactericidal Effect of Calcinated Mg–Fe Layered Double Hydroxide Films Driven by the Fenton Reaction |
| title_sort | enhanced bactericidal effect of calcinated mg fe layered double hydroxide films driven by the fenton reaction |
| topic | antibacterial osteogenic Mg–Fe layered double hydroxides alkaline microenvironment Fenton reaction |
| url | https://www.mdpi.com/1422-0067/24/1/272 |
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