Novel strategy of combined interstitial macrophage depletion with intravenous targeted therapy to ameliorate pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a severe interstitial lung disease with poor prognosis and high mortality rate. In the process of IPF, inflammatory dysregulation of macrophages and massive fibroblast aggregation and proliferation destroy alveoli, which cause pulmonary dysfunction, and ultimat...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006423001138 |
| _version_ | 1797796365972013056 |
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| author | Zhongxian Li Qiang Zhang Jiawei Xiang Mingyuan Zhao Yuan Meng Xuhao Hu Tingting Li Yifeng Nie Huizhen Sun Tun Yan Zhuo Ao Dong Han |
| author_facet | Zhongxian Li Qiang Zhang Jiawei Xiang Mingyuan Zhao Yuan Meng Xuhao Hu Tingting Li Yifeng Nie Huizhen Sun Tun Yan Zhuo Ao Dong Han |
| author_sort | Zhongxian Li |
| collection | DOAJ |
| description | Idiopathic pulmonary fibrosis (IPF) is a severe interstitial lung disease with poor prognosis and high mortality rate. In the process of IPF, inflammatory dysregulation of macrophages and massive fibroblast aggregation and proliferation destroy alveoli, which cause pulmonary dysfunction, and ultimately lead to death due to respiratory failure. In the treatment of IPF, crossing biological barriers and delivering drugs to lung interstitium are the major challenges. In order to avoid the side effect of macrophages proliferation, we proposed, designed, and evaluated the strategy which combined macrophage depletion by intervaginal space injection and intravenous targeted therapy on bleomycin mouse model. We found that it inhibited pulmonary macrophages, reduced macrophage depletion in non-target organs, improved pulmonary drug targeting, impeded the progression of pulmonary fibrosis, and accelerated the recovery of pulmonary function. This combination therapeutic strategy shows good biosafety and efficacy, induces a targeted response, and is promising as a practical new clinical approach towards the treatment of pulmonary fibrosis. |
| first_indexed | 2024-03-13T03:31:59Z |
| format | Article |
| id | doaj.art-063c1f6b69bf4062b51218021018faf2 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-03-13T03:31:59Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-063c1f6b69bf4062b51218021018faf22023-06-24T05:18:39ZengElsevierMaterials Today Bio2590-00642023-06-0120100653Novel strategy of combined interstitial macrophage depletion with intravenous targeted therapy to ameliorate pulmonary fibrosisZhongxian Li0Qiang Zhang1Jiawei Xiang2Mingyuan Zhao3Yuan Meng4Xuhao Hu5Tingting Li6Yifeng Nie7Huizhen Sun8Tun Yan9Zhuo Ao10Dong Han11CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, ChinaHebei Key Lab of Nano-biotechnology, Hebei Key Lab of Applied Chemistry, Yanshan University, Qinhuangdao, 066004, ChinaCAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, ChinaCAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, ChinaCAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, ChinaCAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, ChinaCollege of Life Sciences,Bejing University of Chinese Medicine, Beijing, 100029, ChinaCAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, ChinaCollege of Life Sciences,Bejing University of Chinese Medicine, Beijing, 100029, ChinaCollege of Life Sciences,Bejing University of Chinese Medicine, Beijing, 100029, ChinaCAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China; Corresponding author.CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China; College of Life Sciences,Bejing University of Chinese Medicine, Beijing, 100029, China; Corresponding author. CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.Idiopathic pulmonary fibrosis (IPF) is a severe interstitial lung disease with poor prognosis and high mortality rate. In the process of IPF, inflammatory dysregulation of macrophages and massive fibroblast aggregation and proliferation destroy alveoli, which cause pulmonary dysfunction, and ultimately lead to death due to respiratory failure. In the treatment of IPF, crossing biological barriers and delivering drugs to lung interstitium are the major challenges. In order to avoid the side effect of macrophages proliferation, we proposed, designed, and evaluated the strategy which combined macrophage depletion by intervaginal space injection and intravenous targeted therapy on bleomycin mouse model. We found that it inhibited pulmonary macrophages, reduced macrophage depletion in non-target organs, improved pulmonary drug targeting, impeded the progression of pulmonary fibrosis, and accelerated the recovery of pulmonary function. This combination therapeutic strategy shows good biosafety and efficacy, induces a targeted response, and is promising as a practical new clinical approach towards the treatment of pulmonary fibrosis.http://www.sciencedirect.com/science/article/pii/S2590006423001138Combined strategyIntervaginal space injectionMacrophage depletionPulmonary fibrosisTargeted therapy |
| spellingShingle | Zhongxian Li Qiang Zhang Jiawei Xiang Mingyuan Zhao Yuan Meng Xuhao Hu Tingting Li Yifeng Nie Huizhen Sun Tun Yan Zhuo Ao Dong Han Novel strategy of combined interstitial macrophage depletion with intravenous targeted therapy to ameliorate pulmonary fibrosis Materials Today Bio Combined strategy Intervaginal space injection Macrophage depletion Pulmonary fibrosis Targeted therapy |
| title | Novel strategy of combined interstitial macrophage depletion with intravenous targeted therapy to ameliorate pulmonary fibrosis |
| title_full | Novel strategy of combined interstitial macrophage depletion with intravenous targeted therapy to ameliorate pulmonary fibrosis |
| title_fullStr | Novel strategy of combined interstitial macrophage depletion with intravenous targeted therapy to ameliorate pulmonary fibrosis |
| title_full_unstemmed | Novel strategy of combined interstitial macrophage depletion with intravenous targeted therapy to ameliorate pulmonary fibrosis |
| title_short | Novel strategy of combined interstitial macrophage depletion with intravenous targeted therapy to ameliorate pulmonary fibrosis |
| title_sort | novel strategy of combined interstitial macrophage depletion with intravenous targeted therapy to ameliorate pulmonary fibrosis |
| topic | Combined strategy Intervaginal space injection Macrophage depletion Pulmonary fibrosis Targeted therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590006423001138 |
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