The Effects of Polyvinyl Pyrrolidone Hydrogel Dressing on Open-Wound Healing in Rats
Background: Different compounds and methods have been used for wound healing over years. New dressings such as hydrogels have shown remarkable effects on wound healing. Hydrogels have been considered as favorite wound dressings due to their transparency, exchange of respiratory gases, adsorption of...
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| Format: | Article |
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Isfahan University of Medical Sciences
2015-02-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/4604 |
| _version_ | 1797710876844752896 |
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| author | Reza Fazeli-Varzaneh Seied Jamal Moshtaghian Ardeshir Talebi Fereidoon Abedini |
| author_facet | Reza Fazeli-Varzaneh Seied Jamal Moshtaghian Ardeshir Talebi Fereidoon Abedini |
| author_sort | Reza Fazeli-Varzaneh |
| collection | DOAJ |
| description | Background: Different compounds and methods have been used for wound healing over years. New dressings such as hydrogels have shown remarkable effects on wound healing. Hydrogels have been considered as favorite wound dressings due to their transparency, exchange of respiratory gases, adsorption of water and exudates, regulation of wound temperature, prevention of infections and easy replacement. This study was designed to investigate the effects of polyvinylpyrrolidone hydrogel (PVP) dressing on wound healing in rats.
Methods: 30 male Wistar rats weighing 230 ± 20 g were equally and semi-randomly distributed into 3 groups of control, treated with tetracycline and treated with hydrogel. After anesthesia and shaving the area, a 1 x 1 cm section was made on the skin of the back of the rats. The treatment period was 21 days and measurement of the wound area was performed on the days 0, 7, 10, 14, 17 and 21. Wound tissue samples for histopathologic examination were taken on the days 7 and 14. Data were analyzed via SPSS software using ANOVA test.
Findings: Wound recovery in hydrogel group was significantly faster than other groups (P < 0.05). Duration of the wound presence and skin discoloration was also significantly shorter in hydrogel group (P < 0.05).
Conclusion: The results of this study indicate that the hydrogel dressing leads to quick recovery of cutaneous wound. |
| first_indexed | 2024-03-12T06:58:39Z |
| format | Article |
| id | doaj.art-063d80ab5b6e4fd39c9da3862c54ea3a |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T06:58:39Z |
| publishDate | 2015-02-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-063d80ab5b6e4fd39c9da3862c54ea3a2023-09-02T23:49:35ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2015-02-0132313213421481755The Effects of Polyvinyl Pyrrolidone Hydrogel Dressing on Open-Wound Healing in RatsReza Fazeli-Varzaneh0Seied Jamal Moshtaghian1Ardeshir Talebi2Fereidoon Abedini3MSc Student, Department of Biology, School of Sciences, University of Isfahan, Isfahan, IranAssistant Professor, Department of Biology, School of Sciences, University of Isfahan, Isfahan, IranAssociate Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBurn Causalities Hospital of Isfahan, Isfahan University of Medical Sciences, Isfahan, IranBackground: Different compounds and methods have been used for wound healing over years. New dressings such as hydrogels have shown remarkable effects on wound healing. Hydrogels have been considered as favorite wound dressings due to their transparency, exchange of respiratory gases, adsorption of water and exudates, regulation of wound temperature, prevention of infections and easy replacement. This study was designed to investigate the effects of polyvinylpyrrolidone hydrogel (PVP) dressing on wound healing in rats. Methods: 30 male Wistar rats weighing 230 ± 20 g were equally and semi-randomly distributed into 3 groups of control, treated with tetracycline and treated with hydrogel. After anesthesia and shaving the area, a 1 x 1 cm section was made on the skin of the back of the rats. The treatment period was 21 days and measurement of the wound area was performed on the days 0, 7, 10, 14, 17 and 21. Wound tissue samples for histopathologic examination were taken on the days 7 and 14. Data were analyzed via SPSS software using ANOVA test. Findings: Wound recovery in hydrogel group was significantly faster than other groups (P < 0.05). Duration of the wound presence and skin discoloration was also significantly shorter in hydrogel group (P < 0.05). Conclusion: The results of this study indicate that the hydrogel dressing leads to quick recovery of cutaneous wound.http://jims.mui.ac.ir/index.php/jims/article/view/4604Hydrogel dressingPolyvinylpyrrolidoneWoundRatHistopathology |
| spellingShingle | Reza Fazeli-Varzaneh Seied Jamal Moshtaghian Ardeshir Talebi Fereidoon Abedini The Effects of Polyvinyl Pyrrolidone Hydrogel Dressing on Open-Wound Healing in Rats مجله دانشکده پزشکی اصفهان Hydrogel dressing Polyvinylpyrrolidone Wound Rat Histopathology |
| title | The Effects of Polyvinyl Pyrrolidone Hydrogel Dressing on Open-Wound Healing in Rats |
| title_full | The Effects of Polyvinyl Pyrrolidone Hydrogel Dressing on Open-Wound Healing in Rats |
| title_fullStr | The Effects of Polyvinyl Pyrrolidone Hydrogel Dressing on Open-Wound Healing in Rats |
| title_full_unstemmed | The Effects of Polyvinyl Pyrrolidone Hydrogel Dressing on Open-Wound Healing in Rats |
| title_short | The Effects of Polyvinyl Pyrrolidone Hydrogel Dressing on Open-Wound Healing in Rats |
| title_sort | effects of polyvinyl pyrrolidone hydrogel dressing on open wound healing in rats |
| topic | Hydrogel dressing Polyvinylpyrrolidone Wound Rat Histopathology |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/4604 |
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