Dynamic Adjustments of Parenteral Support in Early Adult Intestinal Failure—Essential Role of Sodium
Intestinal failure (IF) requires parenteral support (PS) substituting energy, water, and electrolytes to compensate intestinal losses and replenish deficits. Convalescence, adaptation, and reconstructive surgery facilitate PS reduction. We analyzed the effect of changes of PS on body mass index (BMI...
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MDPI AG
2020-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/11/3426 |
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| author | Torid Jacob Aenne Glass Maria Witte Johannes Reiner Georg Lamprecht |
| author_facet | Torid Jacob Aenne Glass Maria Witte Johannes Reiner Georg Lamprecht |
| author_sort | Torid Jacob |
| collection | DOAJ |
| description | Intestinal failure (IF) requires parenteral support (PS) substituting energy, water, and electrolytes to compensate intestinal losses and replenish deficits. Convalescence, adaptation, and reconstructive surgery facilitate PS reduction. We analyzed the effect of changes of PS on body mass index (BMI) in early adult IF. Energy, volume, and sodium content of PS and BMI were collected at the initial contact (FIRST), the time of maximal PS and BMI (MAX) and the last contact (LAST). Patients were categorized based on functional anatomy: small bowel enterostomy—group 1, jejuno-colic anastomosis—group 2. Analysis of variance was used to test the relative impact of changes in energy, volume, or sodium. Total of 50 patients were followed for 596 days. Although energy, volume, and sodium support were already high at FIRST, we increased PS to MAX, which was accompanied by a significant BMI increase. Thereafter PS could be reduced significantly, leading to a small BMI decrease in group 1, but not in group 2. Increased sodium support had a stronger impact on BMI than energy or volume. Total of 13 patients were weaned. Dynamic PS adjustments are required in the early phase of adult IF. Vigorous sodium support acts as an independent factor. |
| first_indexed | 2024-03-10T15:00:25Z |
| format | Article |
| id | doaj.art-063faeb4363348c7bba9c29916108c68 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T15:00:25Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-063faeb4363348c7bba9c29916108c682023-11-20T20:10:56ZengMDPI AGNutrients2072-66432020-11-011211342610.3390/nu12113426Dynamic Adjustments of Parenteral Support in Early Adult Intestinal Failure—Essential Role of SodiumTorid Jacob0Aenne Glass1Maria Witte2Johannes Reiner3Georg Lamprecht4Division of Gastroenterology and Endocrinology, Department of Internal Medicine, University Medical Center Rostock, Ernst-Heydemann-Str. 6, 18057 Rostock, GermanyInstitute for Biostatistics and Informatics in Medicine and Ageing Research, University Medical Center Rostock, Ernst-Heydemann-Str. 8, 18057 Rostock, GermanyDepartment of General, Visceral, Vascular and Transplantation Surgery, University Medical Center Rostock, Schillingallee 35, 18057 Rostock, GermanyDivision of Gastroenterology and Endocrinology, Department of Internal Medicine, University Medical Center Rostock, Ernst-Heydemann-Str. 6, 18057 Rostock, GermanyDivision of Gastroenterology and Endocrinology, Department of Internal Medicine, University Medical Center Rostock, Ernst-Heydemann-Str. 6, 18057 Rostock, GermanyIntestinal failure (IF) requires parenteral support (PS) substituting energy, water, and electrolytes to compensate intestinal losses and replenish deficits. Convalescence, adaptation, and reconstructive surgery facilitate PS reduction. We analyzed the effect of changes of PS on body mass index (BMI) in early adult IF. Energy, volume, and sodium content of PS and BMI were collected at the initial contact (FIRST), the time of maximal PS and BMI (MAX) and the last contact (LAST). Patients were categorized based on functional anatomy: small bowel enterostomy—group 1, jejuno-colic anastomosis—group 2. Analysis of variance was used to test the relative impact of changes in energy, volume, or sodium. Total of 50 patients were followed for 596 days. Although energy, volume, and sodium support were already high at FIRST, we increased PS to MAX, which was accompanied by a significant BMI increase. Thereafter PS could be reduced significantly, leading to a small BMI decrease in group 1, but not in group 2. Increased sodium support had a stronger impact on BMI than energy or volume. Total of 13 patients were weaned. Dynamic PS adjustments are required in the early phase of adult IF. Vigorous sodium support acts as an independent factor.https://www.mdpi.com/2072-6643/12/11/3426intestinal failureparenteral supportadaptationreconstructive surgerysodiumBMI |
| spellingShingle | Torid Jacob Aenne Glass Maria Witte Johannes Reiner Georg Lamprecht Dynamic Adjustments of Parenteral Support in Early Adult Intestinal Failure—Essential Role of Sodium Nutrients intestinal failure parenteral support adaptation reconstructive surgery sodium BMI |
| title | Dynamic Adjustments of Parenteral Support in Early Adult Intestinal Failure—Essential Role of Sodium |
| title_full | Dynamic Adjustments of Parenteral Support in Early Adult Intestinal Failure—Essential Role of Sodium |
| title_fullStr | Dynamic Adjustments of Parenteral Support in Early Adult Intestinal Failure—Essential Role of Sodium |
| title_full_unstemmed | Dynamic Adjustments of Parenteral Support in Early Adult Intestinal Failure—Essential Role of Sodium |
| title_short | Dynamic Adjustments of Parenteral Support in Early Adult Intestinal Failure—Essential Role of Sodium |
| title_sort | dynamic adjustments of parenteral support in early adult intestinal failure essential role of sodium |
| topic | intestinal failure parenteral support adaptation reconstructive surgery sodium BMI |
| url | https://www.mdpi.com/2072-6643/12/11/3426 |
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