Genomic Characterization of a Relative of Mumps Virus in Lesser Dawn Bats of Southeast Asia
The importance of genomic surveillance on emerging diseases continues to be highlighted with the ongoing SARS-CoV-2 pandemic. Here, we present an analysis of a new bat-borne mumps virus (MuV) in a captive colony of lesser dawn bats (<i>Eonycteris spelaea</i>). This report describes an in...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/3/659 |
| _version_ | 1797608589568770048 |
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| author | Adrian C. Paskey Xiao Fang Lim Justin H. J. Ng Gregory K. Rice Wan Ni Chia Casandra W. Philipson Randy Foo Regina Z. Cer Kyle A. Long Matthew R. Lueder Lindsay Glang Kenneth G. Frey Theron Hamilton Ian H. Mendenhall Gavin J. Smith Danielle E. Anderson Lin-Fa Wang Kimberly A. Bishop-Lilly |
| author_facet | Adrian C. Paskey Xiao Fang Lim Justin H. J. Ng Gregory K. Rice Wan Ni Chia Casandra W. Philipson Randy Foo Regina Z. Cer Kyle A. Long Matthew R. Lueder Lindsay Glang Kenneth G. Frey Theron Hamilton Ian H. Mendenhall Gavin J. Smith Danielle E. Anderson Lin-Fa Wang Kimberly A. Bishop-Lilly |
| author_sort | Adrian C. Paskey |
| collection | DOAJ |
| description | The importance of genomic surveillance on emerging diseases continues to be highlighted with the ongoing SARS-CoV-2 pandemic. Here, we present an analysis of a new bat-borne mumps virus (MuV) in a captive colony of lesser dawn bats (<i>Eonycteris spelaea</i>). This report describes an investigation of MuV-specific data originally collected as part of a longitudinal virome study of apparently healthy, captive lesser dawn bats in Southeast Asia (BioProject ID PRJNA561193) which was the first report of a MuV-like virus, named dawn bat paramyxovirus (DbPV), in bats outside of Africa. More in-depth analysis of these original RNA sequences in the current report reveals that the new DbPV genome shares only 86% amino acid identity with the RNA-dependent RNA polymerase of its closest relative, the African bat-borne mumps virus (AbMuV). While there is no obvious immediate cause for concern, it is important to continue investigating and monitoring bat-borne MuVs to determine the risk of human infection. |
| first_indexed | 2024-03-11T05:46:25Z |
| format | Article |
| id | doaj.art-06427da554b24dfba0009941c5d23d6e |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T05:46:25Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-06427da554b24dfba0009941c5d23d6e2023-11-17T14:22:32ZengMDPI AGViruses1999-49152023-02-0115365910.3390/v15030659Genomic Characterization of a Relative of Mumps Virus in Lesser Dawn Bats of Southeast AsiaAdrian C. Paskey0Xiao Fang Lim1Justin H. J. Ng2Gregory K. Rice3Wan Ni Chia4Casandra W. Philipson5Randy Foo6Regina Z. Cer7Kyle A. Long8Matthew R. Lueder9Lindsay Glang10Kenneth G. Frey11Theron Hamilton12Ian H. Mendenhall13Gavin J. Smith14Danielle E. Anderson15Lin-Fa Wang16Kimberly A. Bishop-Lilly17Genomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, Frederick, MD 21702, USAProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, SingaporeProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, SingaporeGenomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, Frederick, MD 21702, USAProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, SingaporeGenomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, Frederick, MD 21702, USAProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, SingaporeGenomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, Frederick, MD 21702, USAGenomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, Frederick, MD 21702, USAGenomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, Frederick, MD 21702, USAGenomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, Frederick, MD 21702, USAGenomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, Frederick, MD 21702, USAGenomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, Frederick, MD 21702, USAProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, SingaporeProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, SingaporeProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, SingaporeProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, SingaporeGenomics and Bioinformatics Department, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Fort Detrick, Frederick, MD 21702, USAThe importance of genomic surveillance on emerging diseases continues to be highlighted with the ongoing SARS-CoV-2 pandemic. Here, we present an analysis of a new bat-borne mumps virus (MuV) in a captive colony of lesser dawn bats (<i>Eonycteris spelaea</i>). This report describes an investigation of MuV-specific data originally collected as part of a longitudinal virome study of apparently healthy, captive lesser dawn bats in Southeast Asia (BioProject ID PRJNA561193) which was the first report of a MuV-like virus, named dawn bat paramyxovirus (DbPV), in bats outside of Africa. More in-depth analysis of these original RNA sequences in the current report reveals that the new DbPV genome shares only 86% amino acid identity with the RNA-dependent RNA polymerase of its closest relative, the African bat-borne mumps virus (AbMuV). While there is no obvious immediate cause for concern, it is important to continue investigating and monitoring bat-borne MuVs to determine the risk of human infection.https://www.mdpi.com/1999-4915/15/3/659paramyxoviruses<i>Eonycteris spelaea</i>next-generation sequencinggenomicsvirus discovery |
| spellingShingle | Adrian C. Paskey Xiao Fang Lim Justin H. J. Ng Gregory K. Rice Wan Ni Chia Casandra W. Philipson Randy Foo Regina Z. Cer Kyle A. Long Matthew R. Lueder Lindsay Glang Kenneth G. Frey Theron Hamilton Ian H. Mendenhall Gavin J. Smith Danielle E. Anderson Lin-Fa Wang Kimberly A. Bishop-Lilly Genomic Characterization of a Relative of Mumps Virus in Lesser Dawn Bats of Southeast Asia Viruses paramyxoviruses <i>Eonycteris spelaea</i> next-generation sequencing genomics virus discovery |
| title | Genomic Characterization of a Relative of Mumps Virus in Lesser Dawn Bats of Southeast Asia |
| title_full | Genomic Characterization of a Relative of Mumps Virus in Lesser Dawn Bats of Southeast Asia |
| title_fullStr | Genomic Characterization of a Relative of Mumps Virus in Lesser Dawn Bats of Southeast Asia |
| title_full_unstemmed | Genomic Characterization of a Relative of Mumps Virus in Lesser Dawn Bats of Southeast Asia |
| title_short | Genomic Characterization of a Relative of Mumps Virus in Lesser Dawn Bats of Southeast Asia |
| title_sort | genomic characterization of a relative of mumps virus in lesser dawn bats of southeast asia |
| topic | paramyxoviruses <i>Eonycteris spelaea</i> next-generation sequencing genomics virus discovery |
| url | https://www.mdpi.com/1999-4915/15/3/659 |
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