Dietary amino acid patterns and cardiometabolic risk factors among subjects with obesity; a cross-sectional study
Abstract Background The prevalence of obesity is a growing global public health concern. Certain dietary amino acids have been shown to have a potential therapeutic role in improving metabolic syndrome parameters and body composition in individuals with obesity. However, some amino acids have been l...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-024-01549-w |
| _version_ | 1797274274860367872 |
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| author | Fatemeh Abdi Milad Mohammadzadeh Mahdieh Abbasalizad-Farhangi |
| author_facet | Fatemeh Abdi Milad Mohammadzadeh Mahdieh Abbasalizad-Farhangi |
| author_sort | Fatemeh Abdi |
| collection | DOAJ |
| description | Abstract Background The prevalence of obesity is a growing global public health concern. Certain dietary amino acids have been shown to have a potential therapeutic role in improving metabolic syndrome parameters and body composition in individuals with obesity. However, some amino acids have been linked to an increased risk of cardiometabolic disorders. This cross-sectional study aims to investigate the association between dietary amino acid patterns and cardiometabolic risk factors in individuals with obesity. Methods This cross-sectional study included 335 participants with obesity (57.9% males and 41.5% females) from Tabriz and Tehran, Iran. The participants were between the ages of 20–50, with a body mass index (BMI) of 30 kg/m2 or higher, and free from certain medical conditions. The study examined participants’ general characteristics, conducted anthropometric assessments, dietary assessments, and biochemical assessments. The study also used principal component analysis to identify amino acid intake patterns and determined the association between these patterns and cardiometabolic risk factors in individuals with obesity. Results Upon adjusting for potential confounders, the study found that individuals in the third tertiles of pattern 1 and 2 were more likely to have lower LDL levels (OR = 0.99 and 95% CI (0.98–0.99)) for both. Additionally, a significant decrease in total cholesterol was observed in the third tertiles of pattern 2 in model II (OR = 0.99, 95% CI (0.98–0.99)). These findings suggest a potential cardioprotective effect of these amino acid patterns in managing cardiometabolic risk factors in individuals with obesity. Conclusions This study found that two identified amino acid patterns were associated with lower serum LDL and total cholesterol levels, while a third pattern was associated with higher serum triglycerides. The specific amino acids contributing to these patterns highlight the importance of targeted dietary interventions in managing cardiometabolic risk factors in individuals with obesity. |
| first_indexed | 2024-03-07T14:57:05Z |
| format | Article |
| id | doaj.art-06429be499bf4b309c17c83421c4c5db |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-03-07T14:57:05Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-06429be499bf4b309c17c83421c4c5db2024-03-05T19:22:18ZengBMCBMC Endocrine Disorders1472-68232024-02-0124111410.1186/s12902-024-01549-wDietary amino acid patterns and cardiometabolic risk factors among subjects with obesity; a cross-sectional studyFatemeh Abdi0Milad Mohammadzadeh1Mahdieh Abbasalizad-Farhangi2Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical SciencesDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical SciencesDepartment of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical SciencesAbstract Background The prevalence of obesity is a growing global public health concern. Certain dietary amino acids have been shown to have a potential therapeutic role in improving metabolic syndrome parameters and body composition in individuals with obesity. However, some amino acids have been linked to an increased risk of cardiometabolic disorders. This cross-sectional study aims to investigate the association between dietary amino acid patterns and cardiometabolic risk factors in individuals with obesity. Methods This cross-sectional study included 335 participants with obesity (57.9% males and 41.5% females) from Tabriz and Tehran, Iran. The participants were between the ages of 20–50, with a body mass index (BMI) of 30 kg/m2 or higher, and free from certain medical conditions. The study examined participants’ general characteristics, conducted anthropometric assessments, dietary assessments, and biochemical assessments. The study also used principal component analysis to identify amino acid intake patterns and determined the association between these patterns and cardiometabolic risk factors in individuals with obesity. Results Upon adjusting for potential confounders, the study found that individuals in the third tertiles of pattern 1 and 2 were more likely to have lower LDL levels (OR = 0.99 and 95% CI (0.98–0.99)) for both. Additionally, a significant decrease in total cholesterol was observed in the third tertiles of pattern 2 in model II (OR = 0.99, 95% CI (0.98–0.99)). These findings suggest a potential cardioprotective effect of these amino acid patterns in managing cardiometabolic risk factors in individuals with obesity. Conclusions This study found that two identified amino acid patterns were associated with lower serum LDL and total cholesterol levels, while a third pattern was associated with higher serum triglycerides. The specific amino acids contributing to these patterns highlight the importance of targeted dietary interventions in managing cardiometabolic risk factors in individuals with obesity.https://doi.org/10.1186/s12902-024-01549-wAmino acidsDietary proteinFactor analysisCardi-metabolic factorsObesityAmino acid pattern |
| spellingShingle | Fatemeh Abdi Milad Mohammadzadeh Mahdieh Abbasalizad-Farhangi Dietary amino acid patterns and cardiometabolic risk factors among subjects with obesity; a cross-sectional study BMC Endocrine Disorders Amino acids Dietary protein Factor analysis Cardi-metabolic factors Obesity Amino acid pattern |
| title | Dietary amino acid patterns and cardiometabolic risk factors among subjects with obesity; a cross-sectional study |
| title_full | Dietary amino acid patterns and cardiometabolic risk factors among subjects with obesity; a cross-sectional study |
| title_fullStr | Dietary amino acid patterns and cardiometabolic risk factors among subjects with obesity; a cross-sectional study |
| title_full_unstemmed | Dietary amino acid patterns and cardiometabolic risk factors among subjects with obesity; a cross-sectional study |
| title_short | Dietary amino acid patterns and cardiometabolic risk factors among subjects with obesity; a cross-sectional study |
| title_sort | dietary amino acid patterns and cardiometabolic risk factors among subjects with obesity a cross sectional study |
| topic | Amino acids Dietary protein Factor analysis Cardi-metabolic factors Obesity Amino acid pattern |
| url | https://doi.org/10.1186/s12902-024-01549-w |
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