Characterization of the extrudability of hydrogel-based materials for 3D printing of heat-sensitive drugs
Semi-solid extrusion (SSE), one of the additive manufacturing techniques, is attracting particular attention due to its use for printing thermosensitive drugs. Among the materials used in SSE, hydrogels have received the most attention in pharmaceutical applications due to their ability to provide s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2023-01-01
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| Series: | MATEC Web of Conferences |
| Subjects: | |
| Online Access: | https://www.matec-conferences.org/articles/matecconf/pdf/2023/06/matecconf_sfgp23_06002.pdf |
| _version_ | 1797807559110819840 |
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| author | Aina Morenikeji Baillon Fabien Sescousse Romain Sanchez–Ballester Noelia M. Begu Sylvie Soulairol Ian Sauceau Martial |
| author_facet | Aina Morenikeji Baillon Fabien Sescousse Romain Sanchez–Ballester Noelia M. Begu Sylvie Soulairol Ian Sauceau Martial |
| author_sort | Aina Morenikeji |
| collection | DOAJ |
| description | Semi-solid extrusion (SSE), one of the additive manufacturing techniques, is attracting particular attention due to its use for printing thermosensitive drugs. Among the materials used in SSE, hydrogels have received the most attention in pharmaceutical applications due to their ability to provide spatial and temporal control of the release of various therapeutic agents. 3D printing of these hydrogel-based materials requires a fundamental understanding of their non-Newtonian flow during extrusion. In this work, agar gels were subjected to extrusion tests at apparent shear rates corresponding to their printing speeds. The rheology of these gels was then studied using a laboratory setup consisting of a syringe piston pushed by varying weight and the data obtained was modelled using the Herschel–Bulkley equation to obtain the yield stress, the consistency and flow indices. The 4% (w/w) concentration of agar gel showed the best fit to the modelled data and had the optimal rheological properties. This concentration was thus used in printing cylindrical objects, and the effect of the infill density on the porosity of the objects as well as on the dissolution of a tracer was studied. |
| first_indexed | 2024-03-13T06:24:24Z |
| format | Article |
| id | doaj.art-06437d7099544bdf9dafb664700f1d4b |
| institution | Directory Open Access Journal |
| issn | 2261-236X |
| language | English |
| last_indexed | 2024-03-13T06:24:24Z |
| publishDate | 2023-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | MATEC Web of Conferences |
| spelling | doaj.art-06437d7099544bdf9dafb664700f1d4b2023-06-09T09:28:19ZengEDP SciencesMATEC Web of Conferences2261-236X2023-01-013790600210.1051/matecconf/202337906002matecconf_sfgp23_06002Characterization of the extrudability of hydrogel-based materials for 3D printing of heat-sensitive drugsAina Morenikeji0Baillon Fabien1Sescousse Romain2Sanchez–Ballester Noelia M.3Begu Sylvie4Soulairol Ian5Sauceau Martial6Centre RAPSODEE, IMT Mines Albi, CNRS, Université de ToulouseCentre RAPSODEE, IMT Mines Albi, CNRS, Université de ToulouseCentre RAPSODEE, IMT Mines Albi, CNRS, Université de ToulouseICGM, CNRS, ENSCM, Université de MontpellierICGM, CNRS, ENSCM, Université de MontpellierICGM, CNRS, ENSCM, Université de MontpellierCentre RAPSODEE, IMT Mines Albi, CNRS, Université de ToulouseSemi-solid extrusion (SSE), one of the additive manufacturing techniques, is attracting particular attention due to its use for printing thermosensitive drugs. Among the materials used in SSE, hydrogels have received the most attention in pharmaceutical applications due to their ability to provide spatial and temporal control of the release of various therapeutic agents. 3D printing of these hydrogel-based materials requires a fundamental understanding of their non-Newtonian flow during extrusion. In this work, agar gels were subjected to extrusion tests at apparent shear rates corresponding to their printing speeds. The rheology of these gels was then studied using a laboratory setup consisting of a syringe piston pushed by varying weight and the data obtained was modelled using the Herschel–Bulkley equation to obtain the yield stress, the consistency and flow indices. The 4% (w/w) concentration of agar gel showed the best fit to the modelled data and had the optimal rheological properties. This concentration was thus used in printing cylindrical objects, and the effect of the infill density on the porosity of the objects as well as on the dissolution of a tracer was studied.https://www.matec-conferences.org/articles/matecconf/pdf/2023/06/matecconf_sfgp23_06002.pdfimpression 3dhydrogelsmolécules thermosensiblesrhéologiepédiatrieingénierie des procédés pour la santé |
| spellingShingle | Aina Morenikeji Baillon Fabien Sescousse Romain Sanchez–Ballester Noelia M. Begu Sylvie Soulairol Ian Sauceau Martial Characterization of the extrudability of hydrogel-based materials for 3D printing of heat-sensitive drugs MATEC Web of Conferences impression 3d hydrogels molécules thermosensibles rhéologie pédiatrie ingénierie des procédés pour la santé |
| title | Characterization of the extrudability of hydrogel-based materials for 3D printing of heat-sensitive drugs |
| title_full | Characterization of the extrudability of hydrogel-based materials for 3D printing of heat-sensitive drugs |
| title_fullStr | Characterization of the extrudability of hydrogel-based materials for 3D printing of heat-sensitive drugs |
| title_full_unstemmed | Characterization of the extrudability of hydrogel-based materials for 3D printing of heat-sensitive drugs |
| title_short | Characterization of the extrudability of hydrogel-based materials for 3D printing of heat-sensitive drugs |
| title_sort | characterization of the extrudability of hydrogel based materials for 3d printing of heat sensitive drugs |
| topic | impression 3d hydrogels molécules thermosensibles rhéologie pédiatrie ingénierie des procédés pour la santé |
| url | https://www.matec-conferences.org/articles/matecconf/pdf/2023/06/matecconf_sfgp23_06002.pdf |
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