A New Histone Deacetylase Inhibitor Enhances Radiation Sensitivity through the Induction of Misfolded Protein Aggregation and Autophagy in Triple-Negative Breast Cancer

A New Histone Deacetylase Inhibitor Enhances Radiation Sensitivity through the Induction of Misfolded Protein Aggregation and Autophagy in Triple-Negative Breast Cancer

Radiation therapy (RT) is one of the main treatments for triple-negative breast cancer (TNBC). However, many patients experience RT failure due to the metastatic potential of RT and the radiation resistance of several cancers. Histone deacetylase inhibitors (HDACis) can serve as radiosensitizers. In...

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Bibliographic Details
Main Authors: Hui-Wen Chiu, Ya-Ling Yeh, Sheng-Yow Ho, Yuan-Hua Wu, Bour-Jr Wang, Wei-Jan Huang, Yuan-Soon Ho, Ying-Jan Wang, Li-Ching Chen, Shih-Hsin Tu
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
histone deacetylase inhibitor
aggresome
radiation
autophagy
triple-negative breast cancer
Online Access:https://www.mdpi.com/2072-6694/11/11/1703

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