Clinical and pathological observations in experimentally infected pregnant wistar rats with leptospires
Introduction: Leptospirosis has been experimentally investigated in Wistar rats. Although the rat resists infection, there is documentation in natural infections of the damages caused. Objective: to demonstrate clinical-pathological damages in pregnant Wistar rats inoculated with leptospires. Meth...
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| Format: | Article |
| Language: | Spanish |
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ECIMED
2017-06-01
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| Series: | Revista de Ciencias Médicas de Pinar del Río |
| Subjects: | |
| Online Access: | http://www.revcmpinar.sld.cu/index.php/publicaciones/article/view/3020 |
| _version_ | 1818927997815619584 |
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| author | Juan Manuel Lemus Quintana Hildefonso Caridad Cabezas Alfonso Isvel Zaldívar Garitt Eilín Armas González Yerani Ramos Chang |
| author_facet | Juan Manuel Lemus Quintana Hildefonso Caridad Cabezas Alfonso Isvel Zaldívar Garitt Eilín Armas González Yerani Ramos Chang |
| author_sort | Juan Manuel Lemus Quintana |
| collection | DOAJ |
| description | Introduction: Leptospirosis has been experimentally investigated in Wistar rats. Although the rat resists infection, there is documentation in natural infections of the damages caused.
Objective: to demonstrate clinical-pathological damages in pregnant Wistar rats inoculated with leptospires.
Method: Twelve adult Wistar rats (270 g) maintained under appropriate conditions were used, forming three experimental groups of two rats with their controls. They were inoculated intraperitoneally with 2 ml containing 3 x 10 6 leptospires per ml of L. Ichterohaemorrhagiae, L. Canícola and L. Pomona. The variables were: ingestion of water and food, weight, behavioral changes, irritability, mucosal coloration, skin lesions, abortion, preterm birth, hemorrhages, normal birth, number of offspring, condition and weight of offspring, organ status Bleeding in the uterus or placenta. Organ cuts were made.
Results: it was observed, hyperkinesia, loss of post-inoculated pregnancy, pale mucous membranes, low appetite, low weight, hemorrhages in uterine horns, untroubled horns, bulky organs, infertility, infant and mother death, preterm birth, low birth weight , Offspring with hemorrhagic disorders. Damage to organs studied. Prevalence of circulatory disorders with vasculitis, congestion and hemorrhages in liver, heart, lung, spleen and kidney. In ovary, uterus and placenta acute and chronic inflammatory events, polycystic ovaries, yellow bodies, lymphocytic infiltration, acute, chronic, proliferative endometritis and other alterations.
Conclusions: Similar situation can occur in the pregnant woman when she acquires leptospirosis, without evaluating other damages. Injuries occur in any infected animal species.
LEPTOSPIRA; SEROGROUP; WISTAR RATS. |
| first_indexed | 2024-12-20T03:21:54Z |
| format | Article |
| id | doaj.art-064458c9d5fc447d8a5ede2266faa968 |
| institution | Directory Open Access Journal |
| issn | 1561-3194 |
| language | Spanish |
| last_indexed | 2024-12-20T03:21:54Z |
| publishDate | 2017-06-01 |
| publisher | ECIMED |
| record_format | Article |
| series | Revista de Ciencias Médicas de Pinar del Río |
| spelling | doaj.art-064458c9d5fc447d8a5ede2266faa9682022-12-21T19:55:12ZspaECIMEDRevista de Ciencias Médicas de Pinar del Río1561-31942017-06-012133543611477Clinical and pathological observations in experimentally infected pregnant wistar rats with leptospiresJuan Manuel Lemus Quintana0Hildefonso Caridad Cabezas Alfonso1Isvel Zaldívar Garitt2Eilín Armas González3Yerani Ramos Chang4Universidad de Ciencias Médicas de Pinar del Río.Universidad de Ciencias Médicas de Pinar del Río.Universidad de Ciencias Médicas de Pinar del Río. CubaUniversidad de Ciencias Médicas de Pinar del Río. CubaMédica. Especialista de Medicina General Integral. Instructora.Introduction: Leptospirosis has been experimentally investigated in Wistar rats. Although the rat resists infection, there is documentation in natural infections of the damages caused. Objective: to demonstrate clinical-pathological damages in pregnant Wistar rats inoculated with leptospires. Method: Twelve adult Wistar rats (270 g) maintained under appropriate conditions were used, forming three experimental groups of two rats with their controls. They were inoculated intraperitoneally with 2 ml containing 3 x 10 6 leptospires per ml of L. Ichterohaemorrhagiae, L. Canícola and L. Pomona. The variables were: ingestion of water and food, weight, behavioral changes, irritability, mucosal coloration, skin lesions, abortion, preterm birth, hemorrhages, normal birth, number of offspring, condition and weight of offspring, organ status Bleeding in the uterus or placenta. Organ cuts were made. Results: it was observed, hyperkinesia, loss of post-inoculated pregnancy, pale mucous membranes, low appetite, low weight, hemorrhages in uterine horns, untroubled horns, bulky organs, infertility, infant and mother death, preterm birth, low birth weight , Offspring with hemorrhagic disorders. Damage to organs studied. Prevalence of circulatory disorders with vasculitis, congestion and hemorrhages in liver, heart, lung, spleen and kidney. In ovary, uterus and placenta acute and chronic inflammatory events, polycystic ovaries, yellow bodies, lymphocytic infiltration, acute, chronic, proliferative endometritis and other alterations. Conclusions: Similar situation can occur in the pregnant woman when she acquires leptospirosis, without evaluating other damages. Injuries occur in any infected animal species. LEPTOSPIRA; SEROGROUP; WISTAR RATS.http://www.revcmpinar.sld.cu/index.php/publicaciones/article/view/3020LEPTOSPIRASEROGRUPORATAS WISTAR. |
| spellingShingle | Juan Manuel Lemus Quintana Hildefonso Caridad Cabezas Alfonso Isvel Zaldívar Garitt Eilín Armas González Yerani Ramos Chang Clinical and pathological observations in experimentally infected pregnant wistar rats with leptospires Revista de Ciencias Médicas de Pinar del Río LEPTOSPIRA SEROGRUPO RATAS WISTAR. |
| title | Clinical and pathological observations in experimentally infected pregnant wistar rats with leptospires |
| title_full | Clinical and pathological observations in experimentally infected pregnant wistar rats with leptospires |
| title_fullStr | Clinical and pathological observations in experimentally infected pregnant wistar rats with leptospires |
| title_full_unstemmed | Clinical and pathological observations in experimentally infected pregnant wistar rats with leptospires |
| title_short | Clinical and pathological observations in experimentally infected pregnant wistar rats with leptospires |
| title_sort | clinical and pathological observations in experimentally infected pregnant wistar rats with leptospires |
| topic | LEPTOSPIRA SEROGRUPO RATAS WISTAR. |
| url | http://www.revcmpinar.sld.cu/index.php/publicaciones/article/view/3020 |
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