A Sensitive, Simple, and Fast LC–MS/MS Method for Quantification of Remifentanil in Human Plasma: Applications in Critically Ill Patients’ Plasma during Extracorporeal Membrane Oxygenation

A Sensitive, Simple, and Fast LC–MS/MS Method for Quantification of Remifentanil in Human Plasma: Applications in Critically Ill Patients’ Plasma during Extracorporeal Membrane Oxygenation

A sensitive, simple, and fast liquid chromatography–tandem mass spectrometry (LC–MS/MS) bioanalytical method was developed to determine remifentanil in human plasma and prevent its instability by esterases during quantification. A 20 μL sample of human plasma, acidified with formic acid, was precipi...

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Bibliographic Details
Main Authors: Soon Uk Chae, Ji Seon Kim, Chae Bin Lee, Seong Jun Jo, Kyung Lok Min, Min Jung Chang, Soo Kyung Bae
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Separations
Subjects:
remifentanil
human plasma
LC–MS/MS
validation
Online Access:https://www.mdpi.com/2297-8739/10/6/359

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