Multiparametric Ultrasound of Cervical Lymph Node Metastases in Head and Neck Cancer for Planning Non-Surgical Therapy
Background: We aimed to evaluate multiparametric ultrasound, to achieve a better understanding of the baseline characteristics of suspected cervical lymph node metastases in head and neck cancer before induction chemotherapy or chemoradiation. Methods: From February 2020 to April 2021, our complete...
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MDPI AG
2022-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/8/1842 |
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| author | Julian Künzel Moritz Brandenstein Florian Zeman Luisa Symeou Natascha Platz Batista da Silva Ernst Michael Jung |
| author_facet | Julian Künzel Moritz Brandenstein Florian Zeman Luisa Symeou Natascha Platz Batista da Silva Ernst Michael Jung |
| author_sort | Julian Künzel |
| collection | DOAJ |
| description | Background: We aimed to evaluate multiparametric ultrasound, to achieve a better understanding of the baseline characteristics of suspected cervical lymph node metastases in head and neck cancer before induction chemotherapy or chemoradiation. Methods: From February 2020 to April 2021, our complete ultrasound examination protocol was carried out on clinically evident malignant lymph nodes of histologically proven HNSCC in the pre-therapeutic setting. Results: A total of 13 patients were eligible for analysis. Using elastography, irregular clear hardening in areas in the center of the lymph node could be detected in all cases. Elastographic Q-analysis showed a significantly softer cortex compared to the center and surrounding tissue. The time–intensity curve analysis showed high values for the area under the curve and a short time-to-peak (fast wash-in) in all cases compared to the surrounding tissue. A parametric evaluation of contrast enhanced the ultrasound in the early arterial phase and showed an irregular enhancement from the margin in almost all investigated lymph nodes. These results show that the implementation of comprehensive, multiparametric ultrasound is suitable for classifying suspected lymph node metastasis more precisely than conventional ultrasound alone in the pre-therapeutic setting of HNSCC. Thus, these parameters may be used for improvements in the re-staging after chemoradiation or neoadjuvant therapy monitoring, respectively. |
| first_indexed | 2024-03-09T09:57:58Z |
| format | Article |
| id | doaj.art-06468840bb0a4d5fa9bc698db4bd3a37 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T09:57:58Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-06468840bb0a4d5fa9bc698db4bd3a372023-12-01T23:36:05ZengMDPI AGDiagnostics2075-44182022-07-01128184210.3390/diagnostics12081842Multiparametric Ultrasound of Cervical Lymph Node Metastases in Head and Neck Cancer for Planning Non-Surgical TherapyJulian Künzel0Moritz Brandenstein1Florian Zeman2Luisa Symeou3Natascha Platz Batista da Silva4Ernst Michael Jung5Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Regensburg, 93053 Regensburg, GermanyDepartment of Radiology, University Hospital of Regensburg, 93053 Regensburg, GermanyCenter of Clinical Studies, University Hospital of Regensburg, 93053 Regensburg, GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Regensburg, 93053 Regensburg, GermanyDepartment of Radiology, University Hospital of Regensburg, 93053 Regensburg, GermanyDepartment of Radiology, University Hospital of Regensburg, 93053 Regensburg, GermanyBackground: We aimed to evaluate multiparametric ultrasound, to achieve a better understanding of the baseline characteristics of suspected cervical lymph node metastases in head and neck cancer before induction chemotherapy or chemoradiation. Methods: From February 2020 to April 2021, our complete ultrasound examination protocol was carried out on clinically evident malignant lymph nodes of histologically proven HNSCC in the pre-therapeutic setting. Results: A total of 13 patients were eligible for analysis. Using elastography, irregular clear hardening in areas in the center of the lymph node could be detected in all cases. Elastographic Q-analysis showed a significantly softer cortex compared to the center and surrounding tissue. The time–intensity curve analysis showed high values for the area under the curve and a short time-to-peak (fast wash-in) in all cases compared to the surrounding tissue. A parametric evaluation of contrast enhanced the ultrasound in the early arterial phase and showed an irregular enhancement from the margin in almost all investigated lymph nodes. These results show that the implementation of comprehensive, multiparametric ultrasound is suitable for classifying suspected lymph node metastasis more precisely than conventional ultrasound alone in the pre-therapeutic setting of HNSCC. Thus, these parameters may be used for improvements in the re-staging after chemoradiation or neoadjuvant therapy monitoring, respectively.https://www.mdpi.com/2075-4418/12/8/1842CEUSshear wave elastographyperfusionneck metastasessuperficial lymph nodes |
| spellingShingle | Julian Künzel Moritz Brandenstein Florian Zeman Luisa Symeou Natascha Platz Batista da Silva Ernst Michael Jung Multiparametric Ultrasound of Cervical Lymph Node Metastases in Head and Neck Cancer for Planning Non-Surgical Therapy Diagnostics CEUS shear wave elastography perfusion neck metastases superficial lymph nodes |
| title | Multiparametric Ultrasound of Cervical Lymph Node Metastases in Head and Neck Cancer for Planning Non-Surgical Therapy |
| title_full | Multiparametric Ultrasound of Cervical Lymph Node Metastases in Head and Neck Cancer for Planning Non-Surgical Therapy |
| title_fullStr | Multiparametric Ultrasound of Cervical Lymph Node Metastases in Head and Neck Cancer for Planning Non-Surgical Therapy |
| title_full_unstemmed | Multiparametric Ultrasound of Cervical Lymph Node Metastases in Head and Neck Cancer for Planning Non-Surgical Therapy |
| title_short | Multiparametric Ultrasound of Cervical Lymph Node Metastases in Head and Neck Cancer for Planning Non-Surgical Therapy |
| title_sort | multiparametric ultrasound of cervical lymph node metastases in head and neck cancer for planning non surgical therapy |
| topic | CEUS shear wave elastography perfusion neck metastases superficial lymph nodes |
| url | https://www.mdpi.com/2075-4418/12/8/1842 |
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