Ghrelin: Ghrelin as a Regulatory Peptide in Growth Hormone Secretion
Background: Ghrelin is a type of growth hormone (GH) secretagogue that stimulates the release of GH. It is a first hormone linking gastrointestinal-pituitary axis. Objective: This review highlights the interaction of ghrelin with GHRH and somatostatin to regulate the secretion of GH and intends...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4767/9863_CE(Ra)_F(Sh)_PF1(ABAK)_PFA(AK).pdf |
| Summary: | Background: Ghrelin is a type of growth hormone (GH)
secretagogue that stimulates the release of GH. It is a first
hormone linking gastrointestinal-pituitary axis.
Objective: This review highlights the interaction of ghrelin with
GHRH and somatostatin to regulate the secretion of GH and
intends to explore the possible physiological role of the ghrelinpituitary-GH axis linkage system.
Observation: Ghrelin is highly conserved among species and
is classified into octanoylated (C8:0), decanoylated (C10:0),
decenoylated (C10:1) and nonacylated,ghrelin. Acylated ghrelin
is the major active form of human ghrelin. The primary production
site of ghrelin is the stomach, and it interacts with stomach
ghrelin as well as hypothalamic GHRH and somatostatin in
the regulation of pituitary GH secretion. Ghrelin stimulate GH
release through the GHS receptor to increase intracellular Ca2
+
([Ca2
+] levels via IP3 signal transduction pathway. Ghrelin is a
specific endogenous ligand for the GHS receptor and provides
a definitive proof of the occurance of a GHS–GHS receptor
signalling system in the regulation of GH secretion.
Conclusion: Studies suggests that ghrelin is a powerful
pharmacological agent that exerts a potent, time-dependent
stimulation of pulsatile secretion of GH. |
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| ISSN: | 2249-782X 0973-709X |