The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake?
Human blood has historically been considered a sterile environment. Recently, a thriving microbiome dominated by Firmicutes, Actinobacteria, Proteobacteria, and Bacteroidetes phyla was detected in healthy blood. The localization of these microbes is restricted to some blood cell populations, particu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/13/10422 |
| _version_ | 1797591599913369600 |
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| author | Francesca Sciarra Edoardo Franceschini Federica Campolo Mary Anna Venneri |
| author_facet | Francesca Sciarra Edoardo Franceschini Federica Campolo Mary Anna Venneri |
| author_sort | Francesca Sciarra |
| collection | DOAJ |
| description | Human blood has historically been considered a sterile environment. Recently, a thriving microbiome dominated by Firmicutes, Actinobacteria, Proteobacteria, and Bacteroidetes phyla was detected in healthy blood. The localization of these microbes is restricted to some blood cell populations, particularly the peripheral blood mononuclear cells and erythrocytes. It was hypothesized that the blood microbiome originates from the skin–oral–gut axis. In addition, many studies have evaluated the potential of blood microbiome dysbiosis as a prognostic marker in cardiovascular diseases, cirrhosis, severe liver fibrosis, severe acute pancreatitis, type 2 diabetes, and chronic kidney diseases. The present review aims to summarize current findings and most recent evidence in the field. |
| first_indexed | 2024-03-11T01:39:39Z |
| format | Article |
| id | doaj.art-064928b912624b0f9f609c9b0f643b94 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:39:39Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-064928b912624b0f9f609c9b0f643b942023-11-18T16:37:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124131042210.3390/ijms241310422The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake?Francesca Sciarra0Edoardo Franceschini1Federica Campolo2Mary Anna Venneri3Department of Experimental Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, ItalyHuman blood has historically been considered a sterile environment. Recently, a thriving microbiome dominated by Firmicutes, Actinobacteria, Proteobacteria, and Bacteroidetes phyla was detected in healthy blood. The localization of these microbes is restricted to some blood cell populations, particularly the peripheral blood mononuclear cells and erythrocytes. It was hypothesized that the blood microbiome originates from the skin–oral–gut axis. In addition, many studies have evaluated the potential of blood microbiome dysbiosis as a prognostic marker in cardiovascular diseases, cirrhosis, severe liver fibrosis, severe acute pancreatitis, type 2 diabetes, and chronic kidney diseases. The present review aims to summarize current findings and most recent evidence in the field.https://www.mdpi.com/1422-0067/24/13/10422human blood microbiomebacteriadysbiosisprognostic markermicrobiome |
| spellingShingle | Francesca Sciarra Edoardo Franceschini Federica Campolo Mary Anna Venneri The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? International Journal of Molecular Sciences human blood microbiome bacteria dysbiosis prognostic marker microbiome |
| title | The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? |
| title_full | The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? |
| title_fullStr | The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? |
| title_full_unstemmed | The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? |
| title_short | The Diagnostic Potential of the Human Blood Microbiome: Are We Dreaming or Awake? |
| title_sort | diagnostic potential of the human blood microbiome are we dreaming or awake |
| topic | human blood microbiome bacteria dysbiosis prognostic marker microbiome |
| url | https://www.mdpi.com/1422-0067/24/13/10422 |
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