Vasomotor reactivity measurement using Breath Holding Index to objectively diagnose migraine in Indonesia
Objective. Migraine is currently diagnosed using the subjective fulfilment of the International Headache Society (IHS) criteria. Considering the pathophysiology of endothelial dysfunction in migraine, this study aimed to utilize the breath holding index (BHI) to diagnose migraine objectively by ass...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2023-12-01
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| Series: | Romanian Journal of Neurology |
| Subjects: | |
| Online Access: | https://rjn.com.ro/articles/2023.4/RJN_2023_4_Art-16.pdf |
| _version_ | 1797257856778502144 |
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| author | Salim Harris Teguh A. S. Ranakusuma Al Rasyid Efta Yudiarsah Cleopas Martin Rumende Darto Satoto Aldy S. Rambe Melissa A. L. Witjaksono Kevin M. Saputri |
| author_facet | Salim Harris Teguh A. S. Ranakusuma Al Rasyid Efta Yudiarsah Cleopas Martin Rumende Darto Satoto Aldy S. Rambe Melissa A. L. Witjaksono Kevin M. Saputri |
| author_sort | Salim Harris |
| collection | DOAJ |
| description | Objective. Migraine is currently diagnosed using the subjective fulfilment of the International Headache Society (IHS) criteria. Considering the pathophysiology of endothelial dysfunction in migraine, this study aimed to utilize the breath
holding index (BHI) to diagnose migraine objectively by assessing the vasodilatation response of intracranial arteries in migraine without aura.
Material and method. 128 subjects with primary headache in the interictal phase were cross-sectional recruited and classified into migraine and non-migraine groups. BHI was performed using transcranial Doppler examination. Confirmed
migraine was diagnosed using the validated IHS-equivalent Indonesian Migraine Screen Questionnaire (MS-Q) score of ≥4, BHI of <0.69, and one-month clinical response to topiramate and/or indomethacin administration based on the nature of their headache. Result. This study enrolled 104 and 24 subjects with migraine and non-migraine headache, respectively. The sociodemographic profile was similar between groups. Reduced ipsilateral BHI was more observed in the migraine than the non-migraine group (0.70 vs 1.53, p<0.001), with sensitivity of 49 (39-59) % and specificity of 92 (81-100) % using the established cut off value of 0.69. Conclusion. The breath holding index is a highly specific, moderately sensitive and objective tool to diagnose migraine. Measurement of vasoconstrictive response may be considered to further increase the sensitivity of this objective diagnostic tool. |
| first_indexed | 2024-04-24T22:44:17Z |
| format | Article |
| id | doaj.art-0649bcd685604836b2bccc57f4058e66 |
| institution | Directory Open Access Journal |
| issn | 1843-8148 2069-6094 |
| language | English |
| last_indexed | 2024-04-24T22:44:17Z |
| publishDate | 2023-12-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj.art-0649bcd685604836b2bccc57f4058e662024-03-18T12:36:32ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942023-12-0122428028510.37897/RJN.2023.4.16Vasomotor reactivity measurement using Breath Holding Index to objectively diagnose migraine in Indonesia Salim Harris0Teguh A. S. Ranakusuma1Al Rasyid2Efta Yudiarsah3Cleopas Martin Rumende4Darto Satoto 5Aldy S. Rambe6Melissa A. L. Witjaksono7Kevin M. Saputri8Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaDepartment of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaDepartment of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaFaculty of Mathematics and Natural Sciences, Universitas Indonesia, Jakarta, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaDepartment of Anesthesiology, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaDepartment of Neurology, Faculty of Medicine, Universitas Sumatra Utara, Medan, IndonesiaDepartment of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaDepartment of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaObjective. Migraine is currently diagnosed using the subjective fulfilment of the International Headache Society (IHS) criteria. Considering the pathophysiology of endothelial dysfunction in migraine, this study aimed to utilize the breath holding index (BHI) to diagnose migraine objectively by assessing the vasodilatation response of intracranial arteries in migraine without aura. Material and method. 128 subjects with primary headache in the interictal phase were cross-sectional recruited and classified into migraine and non-migraine groups. BHI was performed using transcranial Doppler examination. Confirmed migraine was diagnosed using the validated IHS-equivalent Indonesian Migraine Screen Questionnaire (MS-Q) score of ≥4, BHI of <0.69, and one-month clinical response to topiramate and/or indomethacin administration based on the nature of their headache. Result. This study enrolled 104 and 24 subjects with migraine and non-migraine headache, respectively. The sociodemographic profile was similar between groups. Reduced ipsilateral BHI was more observed in the migraine than the non-migraine group (0.70 vs 1.53, p<0.001), with sensitivity of 49 (39-59) % and specificity of 92 (81-100) % using the established cut off value of 0.69. Conclusion. The breath holding index is a highly specific, moderately sensitive and objective tool to diagnose migraine. Measurement of vasoconstrictive response may be considered to further increase the sensitivity of this objective diagnostic tool.https://rjn.com.ro/articles/2023.4/RJN_2023_4_Art-16.pdfbreath holding indexmigrainemigraine vascular indextranscranial dopplervasomotor reactivity |
| spellingShingle | Salim Harris Teguh A. S. Ranakusuma Al Rasyid Efta Yudiarsah Cleopas Martin Rumende Darto Satoto Aldy S. Rambe Melissa A. L. Witjaksono Kevin M. Saputri Vasomotor reactivity measurement using Breath Holding Index to objectively diagnose migraine in Indonesia Romanian Journal of Neurology breath holding index migraine migraine vascular index transcranial doppler vasomotor reactivity |
| title | Vasomotor reactivity measurement using Breath Holding Index to objectively diagnose migraine in Indonesia |
| title_full | Vasomotor reactivity measurement using Breath Holding Index to objectively diagnose migraine in Indonesia |
| title_fullStr | Vasomotor reactivity measurement using Breath Holding Index to objectively diagnose migraine in Indonesia |
| title_full_unstemmed | Vasomotor reactivity measurement using Breath Holding Index to objectively diagnose migraine in Indonesia |
| title_short | Vasomotor reactivity measurement using Breath Holding Index to objectively diagnose migraine in Indonesia |
| title_sort | vasomotor reactivity measurement using breath holding index to objectively diagnose migraine in indonesia |
| topic | breath holding index migraine migraine vascular index transcranial doppler vasomotor reactivity |
| url | https://rjn.com.ro/articles/2023.4/RJN_2023_4_Art-16.pdf |
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