Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ex situ innate immune responses

Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ex situ innate immune responses

Access to liver transplantation is limited by a significant organ shortage. The recent introduction of machine perfusion technology allows surgeons to monitor and assess ex situ liver function prior to transplantation. However, many donated organs are of inadequate quality for transplant, though opp...

Full description

Bibliographic Details
Main Authors: Siavash Raigani, John Santiago, Anders Ohman, Megan Heaney, Sofia Baptista, Taylor M. Coe, Reinier J. de Vries, Ivy Rosales, Angela Shih, James F. Markmann, Philip Gruppuso, Korkut Uygun, Jennifer Sanders, Heidi Yeh
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
machine perfusion
liver transplant
apoptosis
caspase
normothermic
ischemia reperfusion injury
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.940094/full

Similar Items

Similar Items