The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study.
There is little knowledge about how factors early in life affect the development of migraine and tension-type headache. We aimed to examine whether growth restriction in utero is associated with development of migraine and frequent tension-type headache in adults.The population-based Nord-Trøndelag...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5391957?pdf=render |
| _version_ | 1819153658555662336 |
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| author | Sigrid Børte Bendik S Winsvold Synne Øien Stensland Milada Cvancarova Småstuen John-Anker Zwart |
| author_facet | Sigrid Børte Bendik S Winsvold Synne Øien Stensland Milada Cvancarova Småstuen John-Anker Zwart |
| author_sort | Sigrid Børte |
| collection | DOAJ |
| description | There is little knowledge about how factors early in life affect the development of migraine and tension-type headache. We aimed to examine whether growth restriction in utero is associated with development of migraine and frequent tension-type headache in adults.The population-based Nord-Trøndelag Health Study (HUNT 3) contained a validated headache questionnaire, which differentiated between migraine and tension-type headache. These data were linked to information on weight and gestational age at birth from the Norwegian Medical Birth Registry. In total 4557 females and 2789 males, aged 19-41 years, were included in this registry-based study. Participants were categorized as appropriate for gestational age (AGA, 10th-90th percentile), small for gestational age (SGA, 3rd-10th percentile) or very small for gestational age (VSGA, < 3rd percentile). Logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI) for migraine and tension-type headache, with exposure being growth restriction at birth.The effect of growth restriction on migraine was modified by sex, with a significant association in males (p<0.001), but not in females (p = 0.20). In particular, males born VSGA were at increased risk of developing migraine (OR 2.73, 95% CI 1.63-4.58, p<0.001), with an intermediate risk among those born SGA (OR 1.50, 95% CI 0.96-2.35, p = 0.08) compared to those born AGA. There was no significant association between growth restriction and frequent TTH (p = 0.051).Growth restriction was associated with increased risk of migraine in adulthood among males, but not among females. This suggests that migraine might, in part, be influenced by early life events, and that males seem to be particularly vulnerable. |
| first_indexed | 2024-12-22T15:08:41Z |
| format | Article |
| id | doaj.art-064b67b6981542fc87edc58bc64252c0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T15:08:41Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-064b67b6981542fc87edc58bc64252c02022-12-21T18:21:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01124e017590810.1371/journal.pone.0175908The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study.Sigrid BørteBendik S WinsvoldSynne Øien StenslandMilada Cvancarova SmåstuenJohn-Anker ZwartThere is little knowledge about how factors early in life affect the development of migraine and tension-type headache. We aimed to examine whether growth restriction in utero is associated with development of migraine and frequent tension-type headache in adults.The population-based Nord-Trøndelag Health Study (HUNT 3) contained a validated headache questionnaire, which differentiated between migraine and tension-type headache. These data were linked to information on weight and gestational age at birth from the Norwegian Medical Birth Registry. In total 4557 females and 2789 males, aged 19-41 years, were included in this registry-based study. Participants were categorized as appropriate for gestational age (AGA, 10th-90th percentile), small for gestational age (SGA, 3rd-10th percentile) or very small for gestational age (VSGA, < 3rd percentile). Logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI) for migraine and tension-type headache, with exposure being growth restriction at birth.The effect of growth restriction on migraine was modified by sex, with a significant association in males (p<0.001), but not in females (p = 0.20). In particular, males born VSGA were at increased risk of developing migraine (OR 2.73, 95% CI 1.63-4.58, p<0.001), with an intermediate risk among those born SGA (OR 1.50, 95% CI 0.96-2.35, p = 0.08) compared to those born AGA. There was no significant association between growth restriction and frequent TTH (p = 0.051).Growth restriction was associated with increased risk of migraine in adulthood among males, but not among females. This suggests that migraine might, in part, be influenced by early life events, and that males seem to be particularly vulnerable.http://europepmc.org/articles/PMC5391957?pdf=render |
| spellingShingle | Sigrid Børte Bendik S Winsvold Synne Øien Stensland Milada Cvancarova Småstuen John-Anker Zwart The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study. PLoS ONE |
| title | The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study. |
| title_full | The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study. |
| title_fullStr | The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study. |
| title_full_unstemmed | The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study. |
| title_short | The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study. |
| title_sort | effect of foetal growth restriction on the development of migraine and tension type headache in adulthood the hunt study |
| url | http://europepmc.org/articles/PMC5391957?pdf=render |
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