Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG)
Objective: Peripheral T-cell lymphomas (PTCLs) are an uncommon and quite heterogeneous group of disorders, representing only 10%-15% of all non-Hodgkin lymphomas. Although both molecular and clinical studies have increased in recent years, we still have little knowledge regarding real-life practice...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2022-08-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-14227 |
| _version_ | 1828030078374641664 |
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| author | Ömür Kayıkçı Özgür Mehtap İsmail Sarı Fatih Demirkan Cengiz Beyan Güven Çetin Filiz Vural Mehmet Yılmaz Erman Öztürk Seval Akpınar Bülent Eser Mehmet Gündüz Yahya Büyükaşık Bahriye Payzin Rahşan Yıldırım Mehmet Hilmi Doğu Atilla Özkan Engin Kelkitli Emre Tekgündüz |
| author_facet | Ömür Kayıkçı Özgür Mehtap İsmail Sarı Fatih Demirkan Cengiz Beyan Güven Çetin Filiz Vural Mehmet Yılmaz Erman Öztürk Seval Akpınar Bülent Eser Mehmet Gündüz Yahya Büyükaşık Bahriye Payzin Rahşan Yıldırım Mehmet Hilmi Doğu Atilla Özkan Engin Kelkitli Emre Tekgündüz |
| author_sort | Ömür Kayıkçı |
| collection | DOAJ |
| description | Objective: Peripheral T-cell lymphomas (PTCLs) are an uncommon and quite heterogeneous group of disorders, representing only 10%-15% of all non-Hodgkin lymphomas. Although both molecular and clinical studies have increased in recent years, we still have little knowledge regarding real-life practice with PTCLs. In this study, we aimed to investigate the clinical characteristics and treatment outcomes of a large population-based cohort of patients presenting with systemic non-cutaneous PTCL. Materials and Methods: We conducted a multicenter retrospective analysis of 190 patients consecutively diagnosed and treated with non-cutaneous PTCLs between 2008 and 2016. Results: Considering all first-line treatment combinations, the overall response rate was 65.9% with 49.4% complete remission (n=81) and 16.5% partial response (n=27). The 5-year overall survival and eventfree survival rates were significantly different between the transplant and non-transplant groups (p<0.01, and p=0.033, respectively). Conclusion: The retrospective analysis of a large volume of real-life data on the Turkish experience regarding non-cutaneous PTCL patients showed consistent results compared to other unselected PTCL cohorts with some minor differences in terms of survival and transplantation outcomes. The long-term outcome of patients who receive autologous hematopoietic cell transplantation as part of upfront consolidation or salvage therapy is favorable compared to patients who are unable to receive high-dose therapy. |
| first_indexed | 2024-04-10T14:21:23Z |
| format | Article |
| id | doaj.art-064de3f44cfb416da6444235fe3ba4b7 |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T14:21:23Z |
| publishDate | 2022-08-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-064de3f44cfb416da6444235fe3ba4b72023-02-15T16:09:17ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632022-08-0139317017710.4274/tjh.galenos.2022.2022.0052TJH-14227Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG)Ömür Kayıkçı0Özgür Mehtap1İsmail Sarı2Fatih Demirkan3Cengiz Beyan4Güven Çetin5Filiz Vural6Mehmet Yılmaz7Erman Öztürk8Seval Akpınar9Bülent Eser10Mehmet Gündüz11Yahya Büyükaşık12Bahriye Payzin13Rahşan Yıldırım14Mehmet Hilmi Doğu15Atilla Özkan16Engin Kelkitli17Emre Tekgündüz18Memorial Bahçelievler Hospital, Clinic of Hematology, İstanbul, TurkeyKocaeli University Faculty of Medicine, Department of Hematology, Kocaeli, TurkeyMemorial Ataşehir Hospital, Clinic of Hematology, İstanbul, TurkeyDokuz Eylül University Faculty of Medicine, Division of Hematology, İzmir, TurkeyUfuk University Faculty of Medicine, Division of Hematology, Ankara, TurkeyBezmialem Vakıf University Faculty of Medicine, Department of Hematology, İstanbul, TurkeyEge University Faculty of Medicine, Department of Hematology, İzmir, TurkeySanko University Faculty of Medicine, Department of Hematology, Gaziantep, TurkeyMedeniyet University Training and Research Hospital, Clinic of Hematology, İstanbul, TurkeyNamık Kemal University Faculty of Medicine, Department of Hematology, Tekirdağ, TurkeyMedical Park Hospital, Clinic of Hematology, İstanbul, TurkeyBiruni University Hospital, Clinic of Hematology, İstanbul, TurkeyHacettepe University Faculty of Medicine, Department of Hematology, Ankara, Turkeyİzmir Katip Çelebi University Atatürk Training and Research Hospital, Clinic of Hematology, İzmir, Turkeyİstinye University Faculty of Medicine, Department of Hematology, İstanbul, TurkeyLiv Hospital, Clinic of Hematology, İstanbul, TurkeyYeditepe University Hospital, Clinic of Hematology, İstanbul, TurkeyOndokuz Mayıs University Faculty of Medicine, Department of Hematology, Samsun, TurkeyMemorial Bahçelievler Hospital, Clinic of Hematology, İstanbul, TurkeyObjective: Peripheral T-cell lymphomas (PTCLs) are an uncommon and quite heterogeneous group of disorders, representing only 10%-15% of all non-Hodgkin lymphomas. Although both molecular and clinical studies have increased in recent years, we still have little knowledge regarding real-life practice with PTCLs. In this study, we aimed to investigate the clinical characteristics and treatment outcomes of a large population-based cohort of patients presenting with systemic non-cutaneous PTCL. Materials and Methods: We conducted a multicenter retrospective analysis of 190 patients consecutively diagnosed and treated with non-cutaneous PTCLs between 2008 and 2016. Results: Considering all first-line treatment combinations, the overall response rate was 65.9% with 49.4% complete remission (n=81) and 16.5% partial response (n=27). The 5-year overall survival and eventfree survival rates were significantly different between the transplant and non-transplant groups (p<0.01, and p=0.033, respectively). Conclusion: The retrospective analysis of a large volume of real-life data on the Turkish experience regarding non-cutaneous PTCL patients showed consistent results compared to other unselected PTCL cohorts with some minor differences in terms of survival and transplantation outcomes. The long-term outcome of patients who receive autologous hematopoietic cell transplantation as part of upfront consolidation or salvage therapy is favorable compared to patients who are unable to receive high-dose therapy.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-14227lymphomasautologous stem cell transplantationt-cell lymphomasnon-hodgkin lymphoma |
| spellingShingle | Ömür Kayıkçı Özgür Mehtap İsmail Sarı Fatih Demirkan Cengiz Beyan Güven Çetin Filiz Vural Mehmet Yılmaz Erman Öztürk Seval Akpınar Bülent Eser Mehmet Gündüz Yahya Büyükaşık Bahriye Payzin Rahşan Yıldırım Mehmet Hilmi Doğu Atilla Özkan Engin Kelkitli Emre Tekgündüz Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG) Turkish Journal of Hematology lymphomas autologous stem cell transplantation t-cell lymphomas non-hodgkin lymphoma |
| title | Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG) |
| title_full | Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG) |
| title_fullStr | Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG) |
| title_full_unstemmed | Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG) |
| title_short | Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG) |
| title_sort | real life experience regarding clinical characteristics and treatment outcome in non cutaneous peripheral t cell lymphomas a multicenter study of the turkish hematology research and education group threg |
| topic | lymphomas autologous stem cell transplantation t-cell lymphomas non-hodgkin lymphoma |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-14227 |
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