Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals
Older individuals exhibiting diminished function of the locus coeruleus while learning new information show faster cognitive decline that is typical for Alzheimer’s disease.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28986-2 |
| _version_ | 1811335533971898368 |
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| author | Prokopis C. Prokopiou Nina Engels-Domínguez Kathryn V. Papp Matthew R. Scott Aaron P. Schultz Christoph Schneider Michelle E. Farrell Rachel F. Buckley Yakeel T. Quiroz Georges El Fakhri Dorene M. Rentz Reisa A. Sperling Keith A. Johnson Heidi I. L. Jacobs |
| author_facet | Prokopis C. Prokopiou Nina Engels-Domínguez Kathryn V. Papp Matthew R. Scott Aaron P. Schultz Christoph Schneider Michelle E. Farrell Rachel F. Buckley Yakeel T. Quiroz Georges El Fakhri Dorene M. Rentz Reisa A. Sperling Keith A. Johnson Heidi I. L. Jacobs |
| author_sort | Prokopis C. Prokopiou |
| collection | DOAJ |
| description | Older individuals exhibiting diminished function of the locus coeruleus while learning new information show faster cognitive decline that is typical for Alzheimer’s disease. |
| first_indexed | 2024-04-13T17:25:37Z |
| format | Article |
| id | doaj.art-064e0e4a05864dea8910777843fb04ad |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T17:25:37Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-064e0e4a05864dea8910777843fb04ad2022-12-22T02:37:47ZengNature PortfolioNature Communications2041-17232022-03-0113111410.1038/s41467-022-28986-2Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individualsProkopis C. Prokopiou0Nina Engels-Domínguez1Kathryn V. Papp2Matthew R. Scott3Aaron P. Schultz4Christoph Schneider5Michelle E. Farrell6Rachel F. Buckley7Yakeel T. Quiroz8Georges El Fakhri9Dorene M. Rentz10Reisa A. Sperling11Keith A. Johnson12Heidi I. L. Jacobs13Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical SchoolGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical SchoolCenter for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical SchoolDepartment of Neurology, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Neurology, Massachusetts General Hospital, Harvard Medical SchoolGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Neurology, Massachusetts General Hospital, Harvard Medical SchoolCenter for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical SchoolDepartment of Neurology, Massachusetts General Hospital, Harvard Medical SchoolGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical SchoolCenter for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical SchoolCenter for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical SchoolGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical SchoolGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical SchoolOlder individuals exhibiting diminished function of the locus coeruleus while learning new information show faster cognitive decline that is typical for Alzheimer’s disease.https://doi.org/10.1038/s41467-022-28986-2 |
| spellingShingle | Prokopis C. Prokopiou Nina Engels-Domínguez Kathryn V. Papp Matthew R. Scott Aaron P. Schultz Christoph Schneider Michelle E. Farrell Rachel F. Buckley Yakeel T. Quiroz Georges El Fakhri Dorene M. Rentz Reisa A. Sperling Keith A. Johnson Heidi I. L. Jacobs Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals Nature Communications |
| title | Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals |
| title_full | Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals |
| title_fullStr | Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals |
| title_full_unstemmed | Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals |
| title_short | Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals |
| title_sort | lower novelty related locus coeruleus function is associated with aβ related cognitive decline in clinically healthy individuals |
| url | https://doi.org/10.1038/s41467-022-28986-2 |
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