Effects of vitamin D-fortified yogurt in comparison to oral vitamin D supplement on hyperlipidemia in pre-diabetic patients: A randomized clinical trial
In this study, the effect of vitamin D-fortified yogurt consumption and oral vitamin D supplementation on serum lipid profile in pre-diabetic patients with hyperlipidemia was investigated. This study was performed on 60 pre-diabetes patients who were randomly divided into two groups: group A (recipi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646461830567X |
| _version_ | 1818948745971105792 |
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| author | Roghayeh Mostafai Seyed Mostafa Nachvakc Reza Mohammadi Ramon S. Rocha Marcia C. da Silva Erick A. Esmerino Kamila O. Nascimento Adriano G. Cruz Amir M. Mortazavian |
| author_facet | Roghayeh Mostafai Seyed Mostafa Nachvakc Reza Mohammadi Ramon S. Rocha Marcia C. da Silva Erick A. Esmerino Kamila O. Nascimento Adriano G. Cruz Amir M. Mortazavian |
| author_sort | Roghayeh Mostafai |
| collection | DOAJ |
| description | In this study, the effect of vitamin D-fortified yogurt consumption and oral vitamin D supplementation on serum lipid profile in pre-diabetic patients with hyperlipidemia was investigated. This study was performed on 60 pre-diabetes patients who were randomly divided into two groups: group A (recipient of fortified yogurt with 1000 IU vitamin D) and group B (recipient of oral vitamin D supplement in a dose of 1000 IU) for three months. The mean serum level of 25(OH) D3 was increased significantly in the fortified yogurt group (P = 0.001) and the oral supplement group (p < 0.001). The within-group analysis of lipid indices showed a significant reduction in the mean serum triglyceride levels in the fortified yogurt group (P = 0.001) and oral supplement group (P < 0.001), Also, showed a significant reduction in mean serum total cholesterol, LDL-C (P < 0.001) and HDL-C (P = 0.01) in both groups. The between-group comparison analysis of mean lipid indices changes showed that serum level of Triglyceride in oral supplement group were significantly more than fortified yogurt group (P = 0.03). Yogurt fortification with vitamin D could be suitable strategy to reduce the prevalence of vitamin D deficiency and consequently to improve the serum lipid profile in hyperlipidemic individuals. |
| first_indexed | 2024-12-20T08:51:41Z |
| format | Article |
| id | doaj.art-06516770000842c4bf458f21eb2c6b3b |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T08:51:41Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-06516770000842c4bf458f21eb2c6b3b2022-12-21T19:46:06ZengElsevierJournal of Functional Foods1756-46462019-01-0152116120Effects of vitamin D-fortified yogurt in comparison to oral vitamin D supplement on hyperlipidemia in pre-diabetic patients: A randomized clinical trialRoghayeh Mostafai0Seyed Mostafa Nachvakc1Reza Mohammadi2Ramon S. Rocha3Marcia C. da Silva4Erick A. Esmerino5Kamila O. Nascimento6Adriano G. Cruz7Amir M. Mortazavian8Nutritional Sciences Department, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, IranNutritional Sciences Department, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; Corresponding authors.Department of Food Science and Technology, School of Nutrition Sciences and Food Technology, Research Center for Environmental Determinants of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran; Corresponding authors.Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro (IFRJ), Departamento de Alimentos, 20270-021 Rio de Janeiro, BrazilInstituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro (IFRJ), Departamento de Alimentos, 20270-021 Rio de Janeiro, BrazilUniversidade Federal Fluminense (UFF), Faculdade de Veterinária, 24230-340 Niterói, BrazilUniversidade Federal Rural do Rio de Janeiro (UFRRJ), Departamento de Tecnologia de Alimentos (DTA), 23890-000 Seropédica, RJ, BrazilInstituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro (IFRJ), Departamento de Alimentos, 20270-021 Rio de Janeiro, BrazilDepartment of Food Science and Technology, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences, Food Science and Technology, Shahid Beheshti University of Medical Sciences, IranIn this study, the effect of vitamin D-fortified yogurt consumption and oral vitamin D supplementation on serum lipid profile in pre-diabetic patients with hyperlipidemia was investigated. This study was performed on 60 pre-diabetes patients who were randomly divided into two groups: group A (recipient of fortified yogurt with 1000 IU vitamin D) and group B (recipient of oral vitamin D supplement in a dose of 1000 IU) for three months. The mean serum level of 25(OH) D3 was increased significantly in the fortified yogurt group (P = 0.001) and the oral supplement group (p < 0.001). The within-group analysis of lipid indices showed a significant reduction in the mean serum triglyceride levels in the fortified yogurt group (P = 0.001) and oral supplement group (P < 0.001), Also, showed a significant reduction in mean serum total cholesterol, LDL-C (P < 0.001) and HDL-C (P = 0.01) in both groups. The between-group comparison analysis of mean lipid indices changes showed that serum level of Triglyceride in oral supplement group were significantly more than fortified yogurt group (P = 0.03). Yogurt fortification with vitamin D could be suitable strategy to reduce the prevalence of vitamin D deficiency and consequently to improve the serum lipid profile in hyperlipidemic individuals.http://www.sciencedirect.com/science/article/pii/S175646461830567XVitamin D-fortified yogurtDeficiencyHyperlipidemiaSupplementPre-diabetes |
| spellingShingle | Roghayeh Mostafai Seyed Mostafa Nachvakc Reza Mohammadi Ramon S. Rocha Marcia C. da Silva Erick A. Esmerino Kamila O. Nascimento Adriano G. Cruz Amir M. Mortazavian Effects of vitamin D-fortified yogurt in comparison to oral vitamin D supplement on hyperlipidemia in pre-diabetic patients: A randomized clinical trial Journal of Functional Foods Vitamin D-fortified yogurt Deficiency Hyperlipidemia Supplement Pre-diabetes |
| title | Effects of vitamin D-fortified yogurt in comparison to oral vitamin D supplement on hyperlipidemia in pre-diabetic patients: A randomized clinical trial |
| title_full | Effects of vitamin D-fortified yogurt in comparison to oral vitamin D supplement on hyperlipidemia in pre-diabetic patients: A randomized clinical trial |
| title_fullStr | Effects of vitamin D-fortified yogurt in comparison to oral vitamin D supplement on hyperlipidemia in pre-diabetic patients: A randomized clinical trial |
| title_full_unstemmed | Effects of vitamin D-fortified yogurt in comparison to oral vitamin D supplement on hyperlipidemia in pre-diabetic patients: A randomized clinical trial |
| title_short | Effects of vitamin D-fortified yogurt in comparison to oral vitamin D supplement on hyperlipidemia in pre-diabetic patients: A randomized clinical trial |
| title_sort | effects of vitamin d fortified yogurt in comparison to oral vitamin d supplement on hyperlipidemia in pre diabetic patients a randomized clinical trial |
| topic | Vitamin D-fortified yogurt Deficiency Hyperlipidemia Supplement Pre-diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S175646461830567X |
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