Emerging Roles of cGAS-STING Signaling in Mediating Ocular Inflammation

Emerging Roles of cGAS-STING Signaling in Mediating Ocular Inflammation

Cyclic GMP-AMP (cGAMP) synthase (cGAS), a sensor of cytosolic DNA, recognizes cytoplasmic nucleic acids to activate the innate immune responses via generation of the second messenger cGAMP and subsequent activation of the stimulator of interferon genes (STINGs). The cGAS-STING signaling has multiple...

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Bibliographic Details
Main Authors: Linbin Zhou, Bo Man Ho, Hoi Ying Emily Chan, Yan Tong, Lin Du, Jing Na He, Danny Siu-Chun Ng, Clement C. Tham, Chi Pui Pang, Wai Kit Chu
Format: Article
Language:English
Published: Karger Publishers 2023-10-01
Series:Journal of Innate Immunity
Subjects:
cgas-sting signaling
ocular inflammation
keratitis
diabetic retinopathy
age-related macular degeneration
uveitis
Online Access:https://beta.karger.com/Article/FullText/533897

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