Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil
Drug resistance in the treatment of neglected parasitic diseases, such as leishmaniasis and trypanosomiasis, has led to the search and development of alternative drugs from plant origins. In this context, the essential oil extracted by hydro-distillation from Lantana camara leaves was tested against...
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MDPI AG
2016-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/2/209 |
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| author | Luiz Marivando Barros Antonia Eliene Duarte Maria Flaviana Bezerra Morais-Braga Emily Pansera Waczuk Celeste Vega Nadghia Figueiredo Leite Irwin Rose Alencar de Menezes Henrique Douglas Melo Coutinho João Batista Teixeira Rocha Jean Paul Kamdem |
| author_facet | Luiz Marivando Barros Antonia Eliene Duarte Maria Flaviana Bezerra Morais-Braga Emily Pansera Waczuk Celeste Vega Nadghia Figueiredo Leite Irwin Rose Alencar de Menezes Henrique Douglas Melo Coutinho João Batista Teixeira Rocha Jean Paul Kamdem |
| author_sort | Luiz Marivando Barros |
| collection | DOAJ |
| description | Drug resistance in the treatment of neglected parasitic diseases, such as leishmaniasis and trypanosomiasis, has led to the search and development of alternative drugs from plant origins. In this context, the essential oil extracted by hydro-distillation from Lantana camara leaves was tested against Leishmania braziliensis and Trypanosoma cruzi. The results demonstrated that L. camara essential oil inhibited T. cruzi and L. braziliensis with IC50 of 201.94 μg/mL and 72.31 μg/mL, respectively. L. camara essential oil was found to be toxic to NCTC929 fibroblasts at 500 μg/mL (IC50 = 301.42 μg/mL). The composition of L. camara essential oil analyzed by gas chromatography–mass spectrometry (GC/MS) revealed large amounts of (E)-caryophyllene (23.75%), biciclogermacrene (15.80%), germacrene D (11.73%), terpinolene (6.1%), and sabinene (5.92%), which might be, at least in part, responsible for its activity. Taken together, our results suggest that L. camara essential oil may be an important source of therapeutic agents for the development of alternative drugs against parasitic diseases. |
| first_indexed | 2024-12-13T04:19:37Z |
| format | Article |
| id | doaj.art-065578a98a924c158e88cb0a89302fa7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-13T04:19:37Z |
| publishDate | 2016-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-065578a98a924c158e88cb0a89302fa72022-12-21T23:59:47ZengMDPI AGMolecules1420-30492016-02-0121220910.3390/molecules21020209molecules21020209Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential OilLuiz Marivando Barros0Antonia Eliene Duarte1Maria Flaviana Bezerra Morais-Braga2Emily Pansera Waczuk3Celeste Vega4Nadghia Figueiredo Leite5Irwin Rose Alencar de Menezes6Henrique Douglas Melo Coutinho7João Batista Teixeira Rocha8Jean Paul Kamdem9Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, BrazilLaboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, BrazilLaboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, BrazilPost-Graduate Program in Biological Sciences, Biochemical Toxicology, Federal University of Santa Maria, Santa Maria-RS, CEP 97105-900, BrazilLaboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, BrazilLaboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, BrazilProgram of Post-Graduation in Molecular Bioprospection, Laboratory of Pharmacology and Molecular Chemistry, Chemistry Biology Department, Regional University of Cariri, Crato, CEP 63105-000, BrazilLaboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, BrazilPost-Graduate Program in Biological Sciences, Biochemical Toxicology, Federal University of Santa Maria, Santa Maria-RS, CEP 97105-900, BrazilPost-Graduate Program in Biological Sciences, Biochemical Toxicology, Federal University of Santa Maria, Santa Maria-RS, CEP 97105-900, BrazilDrug resistance in the treatment of neglected parasitic diseases, such as leishmaniasis and trypanosomiasis, has led to the search and development of alternative drugs from plant origins. In this context, the essential oil extracted by hydro-distillation from Lantana camara leaves was tested against Leishmania braziliensis and Trypanosoma cruzi. The results demonstrated that L. camara essential oil inhibited T. cruzi and L. braziliensis with IC50 of 201.94 μg/mL and 72.31 μg/mL, respectively. L. camara essential oil was found to be toxic to NCTC929 fibroblasts at 500 μg/mL (IC50 = 301.42 μg/mL). The composition of L. camara essential oil analyzed by gas chromatography–mass spectrometry (GC/MS) revealed large amounts of (E)-caryophyllene (23.75%), biciclogermacrene (15.80%), germacrene D (11.73%), terpinolene (6.1%), and sabinene (5.92%), which might be, at least in part, responsible for its activity. Taken together, our results suggest that L. camara essential oil may be an important source of therapeutic agents for the development of alternative drugs against parasitic diseases.http://www.mdpi.com/1420-3049/21/2/209Lantana camaraLeishmania braziliensisTrypanosoma cruziessential oil |
| spellingShingle | Luiz Marivando Barros Antonia Eliene Duarte Maria Flaviana Bezerra Morais-Braga Emily Pansera Waczuk Celeste Vega Nadghia Figueiredo Leite Irwin Rose Alencar de Menezes Henrique Douglas Melo Coutinho João Batista Teixeira Rocha Jean Paul Kamdem Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil Molecules Lantana camara Leishmania braziliensis Trypanosoma cruzi essential oil |
| title | Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil |
| title_full | Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil |
| title_fullStr | Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil |
| title_full_unstemmed | Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil |
| title_short | Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil |
| title_sort | chemical characterization and trypanocidal leishmanicidal and cytotoxicity potential of lantana camara l verbenaceae essential oil |
| topic | Lantana camara Leishmania braziliensis Trypanosoma cruzi essential oil |
| url | http://www.mdpi.com/1420-3049/21/2/209 |
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