Protein Kinase Inhibitors as a New Target for Immune System Modulation and Brain Cancer Management
High-grade brain tumors are malignant tumors with poor survival and remain the most difficult tumors to treat. An important contributing factor to the development and progression of brain tumors is their ability to evade the immune system. Several immunotherapeutic strategies including vaccines and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/24/15693 |
| _version_ | 1797457240072912896 |
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| author | Alessia Filippone Deborah Mannino Giovanna Casili Marika Lanza Irene Paterniti Salvatore Cuzzocrea Anna Paola Capra Lorenzo Colarossi Dario Giuffrida Sofia Paola Lombardo Emanuela Esposito |
| author_facet | Alessia Filippone Deborah Mannino Giovanna Casili Marika Lanza Irene Paterniti Salvatore Cuzzocrea Anna Paola Capra Lorenzo Colarossi Dario Giuffrida Sofia Paola Lombardo Emanuela Esposito |
| author_sort | Alessia Filippone |
| collection | DOAJ |
| description | High-grade brain tumors are malignant tumors with poor survival and remain the most difficult tumors to treat. An important contributing factor to the development and progression of brain tumors is their ability to evade the immune system. Several immunotherapeutic strategies including vaccines and checkpoint inhibitors have been studied to improve the effectiveness of the immune system in destroying cancer cells. Recent studies have shown that kinase inhibitors, capable of inhibiting signal transduction cascades that affect cell proliferation, migration, and angiogenesis, have additional immunological effects. In this review, we explain the beneficial therapeutic effects of novel small-molecule kinase inhibitors and explore how, through different mechanisms, they increase the protective antitumor immune response in high-grade brain tumors. |
| first_indexed | 2024-03-09T16:19:22Z |
| format | Article |
| id | doaj.art-06564391c12e44ecac5639c1edd6ea32 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:19:22Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-06564391c12e44ecac5639c1edd6ea322023-11-24T15:26:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123241569310.3390/ijms232415693Protein Kinase Inhibitors as a New Target for Immune System Modulation and Brain Cancer ManagementAlessia Filippone0Deborah Mannino1Giovanna Casili2Marika Lanza3Irene Paterniti4Salvatore Cuzzocrea5Anna Paola Capra6Lorenzo Colarossi7Dario Giuffrida8Sofia Paola Lombardo9Emanuela Esposito10Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, 31, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, 31, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, 31, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, 31, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, 31, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, 31, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, 31, 98166 Messina, ItalyIstituto Oncologico del Mediterraneo, Via Penninazzo, Viagrande, 7, 95029 Catania, ItalyIstituto Oncologico del Mediterraneo, Via Penninazzo, Viagrande, 7, 95029 Catania, ItalyIstituto Oncologico del Mediterraneo, Via Penninazzo, Viagrande, 7, 95029 Catania, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, 31, 98166 Messina, ItalyHigh-grade brain tumors are malignant tumors with poor survival and remain the most difficult tumors to treat. An important contributing factor to the development and progression of brain tumors is their ability to evade the immune system. Several immunotherapeutic strategies including vaccines and checkpoint inhibitors have been studied to improve the effectiveness of the immune system in destroying cancer cells. Recent studies have shown that kinase inhibitors, capable of inhibiting signal transduction cascades that affect cell proliferation, migration, and angiogenesis, have additional immunological effects. In this review, we explain the beneficial therapeutic effects of novel small-molecule kinase inhibitors and explore how, through different mechanisms, they increase the protective antitumor immune response in high-grade brain tumors.https://www.mdpi.com/1422-0067/23/24/15693brain tumorsprotein kinase inhibitorimmune systemtumor microenvironmentanti-tumor immunity |
| spellingShingle | Alessia Filippone Deborah Mannino Giovanna Casili Marika Lanza Irene Paterniti Salvatore Cuzzocrea Anna Paola Capra Lorenzo Colarossi Dario Giuffrida Sofia Paola Lombardo Emanuela Esposito Protein Kinase Inhibitors as a New Target for Immune System Modulation and Brain Cancer Management International Journal of Molecular Sciences brain tumors protein kinase inhibitor immune system tumor microenvironment anti-tumor immunity |
| title | Protein Kinase Inhibitors as a New Target for Immune System Modulation and Brain Cancer Management |
| title_full | Protein Kinase Inhibitors as a New Target for Immune System Modulation and Brain Cancer Management |
| title_fullStr | Protein Kinase Inhibitors as a New Target for Immune System Modulation and Brain Cancer Management |
| title_full_unstemmed | Protein Kinase Inhibitors as a New Target for Immune System Modulation and Brain Cancer Management |
| title_short | Protein Kinase Inhibitors as a New Target for Immune System Modulation and Brain Cancer Management |
| title_sort | protein kinase inhibitors as a new target for immune system modulation and brain cancer management |
| topic | brain tumors protein kinase inhibitor immune system tumor microenvironment anti-tumor immunity |
| url | https://www.mdpi.com/1422-0067/23/24/15693 |
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