TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients

TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients

Abstract Background SARS-coronavirus-2 enters host cells through binding of the Spike protein to ACE2 receptor and subsequent S priming by the TMPRSS2 protease. We aim to assess differences in both ACE2 and TMPRSS2 expression in normal tissues from oral cavity, pharynx, larynx and lung tissues as we...

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Bibliographic Details
Main Authors: Andrea Sacconi, Sara Donzelli, Claudio Pulito, Stefano Ferrero, Francesca Spinella, Aldo Morrone, Marta Rigoni, Fulvia Pimpinelli, Fabrizio Ensoli, Giuseppe Sanguineti, Raul Pellini, Nishant Agrawal, Evgeny Izumchenko, Gennaro Ciliberto, Aldo Giannì, Paola Muti, Sabrina Strano, Giovanni Blandino
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
SARS-CoV-2
TMPRSS2
HNSCC
microRNAs TP53
MYC
Online Access:http://link.springer.com/article/10.1186/s13046-020-01708-6

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