Concurrent adult pulmonary tuberculosis prevalence survey using digital radiography and Xpert MTB/RIF Ultra and child interferon-gamma release assay Mycobacterium tuberculosis infection survey in Karachi, Pakistan: a study protocol [version 1; peer review: 2 approved]
Background: Assessment of the effectiveness of tuberculosis control strategies requires the periodic measurement of M. tuberculosis transmission in populations, which is notoriously difficult. One well-established method is to measure the prevalence of infectious pulmonary tuberculosis in the popula...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wellcome
2020-07-01
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| Series: | Wellcome Open Research |
| Online Access: | https://wellcomeopenresearch.org/articles/5-159/v1 |
| _version_ | 1828910038166536192 |
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| author | Palwasha Y. Khan M. Shariq Paracha Chris Grundy Saadia Saeed Maqboola Dojki Falak Madhani Liesl Page-Shipp Nazia Khursheed Waleed Rabbani Najam Riaz Saira Khowaja Owais Hussain Ali Habib Uzma Khan Katharina Kranzer Rashida A. Ferrand James J. Lewis Aamir J. Khan Katherine L. Fielding |
| author_facet | Palwasha Y. Khan M. Shariq Paracha Chris Grundy Saadia Saeed Maqboola Dojki Falak Madhani Liesl Page-Shipp Nazia Khursheed Waleed Rabbani Najam Riaz Saira Khowaja Owais Hussain Ali Habib Uzma Khan Katharina Kranzer Rashida A. Ferrand James J. Lewis Aamir J. Khan Katherine L. Fielding |
| author_sort | Palwasha Y. Khan |
| collection | DOAJ |
| description | Background: Assessment of the effectiveness of tuberculosis control strategies requires the periodic measurement of M. tuberculosis transmission in populations, which is notoriously difficult. One well-established method is to measure the prevalence of infectious pulmonary tuberculosis in the population which is then repeated at a second time point after a period of ‘intervention’, such as scale up of the Search-Treat-Prevent strategy of the Zero TB Cities initiative, allowing for a ‘before and after’ comparison. Protocol: The concurrent adult pulmonary tuberculosis prevalence survey (using digital radiography and Xpert MTB/RIF Ultra) and child M. tuberculosis infection survey (using QuantiFERON-TB® Gold Plus) will primarily provide a baseline measure of the burden of adult infectious tuberculosis in Karachi and assess whether a large-scale interferon gamma release assay survey in children aged 2 to 4 years is feasible. The target population for the prevalence survey is comprised of a stratified random sample of all adults aged 15 years and above and all children aged 2 to 4 years resident in four districts in Karachi. The survey procedures and analyses to estimate pulmonary tuberculosis prevalence are based on the World Health Organization methodology for tuberculosis prevalence surveys. Ethics and dissemination: The study protocol has been approved by the Interactive Research Development / The Indus Hospital Research Centre Research Ethics Committee in Karachi, Pakistan and the London School of Hygiene & Tropical Medicine Research Ethics Committee. Due to non-representative sampling in this setting, where a large proportion of the population are illiterate and are reluctant to provide fingerprints due to concerns about personal security, verbal informed consent will be obtained from each eligible participant or guardian. Results will be submitted to international peer-reviewed journals, presented at international conferences and shared with participating communities and with the Provincial and National TB programme. |
| first_indexed | 2024-12-13T18:37:17Z |
| format | Article |
| id | doaj.art-0657b0a22843497c85b0e68645ec0e58 |
| institution | Directory Open Access Journal |
| issn | 2398-502X |
| language | English |
| last_indexed | 2024-12-13T18:37:17Z |
| publishDate | 2020-07-01 |
| publisher | Wellcome |
| record_format | Article |
| series | Wellcome Open Research |
| spelling | doaj.art-0657b0a22843497c85b0e68645ec0e582022-12-21T23:35:20ZengWellcomeWellcome Open Research2398-502X2020-07-01510.12688/wellcomeopenres.15963.117507Concurrent adult pulmonary tuberculosis prevalence survey using digital radiography and Xpert MTB/RIF Ultra and child interferon-gamma release assay Mycobacterium tuberculosis infection survey in Karachi, Pakistan: a study protocol [version 1; peer review: 2 approved]Palwasha Y. Khan0M. Shariq Paracha1Chris Grundy2Saadia Saeed3Maqboola Dojki4Falak Madhani5Liesl Page-Shipp6Nazia Khursheed7Waleed Rabbani8Najam Riaz9Saira Khowaja10Owais Hussain11Ali Habib12Uzma Khan13Katharina Kranzer14Rashida A. Ferrand15James J. Lewis16Aamir J. Khan17Katherine L. Fielding18Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UKInteractive Research and Development, Karachi, PakistanDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UKInteractive Research and Development, Karachi, PakistanThe Indus Health Network, Karachi, PakistanThe Indus Health Network, Karachi, PakistanInteractive Research and Development Global, Singapore, SingaporeThe Indus Health Network, Karachi, PakistanInteractive Research and Development, Karachi, PakistanThe Indus Health Network, Karachi, PakistanInteractive Research and Development, Karachi, PakistanInteractive Health Solutions, Karachi, PakistanInteractive Health Solutions, Karachi, PakistanInteractive Research and Development Global, Dubai, United Arab EmiratesClinical Research Department, London School of Hygiene & Tropical Medicine, London, UKClinical Research Department, London School of Hygiene & Tropical Medicine, London, UKY Lab – the Public Services Innovation Lab for Wales, Cardiff University, Cardiff, UKInteractive Research and Development Global, Singapore, SingaporeTB Centre, London School of Hygiene & Tropical Medicine, London, UKBackground: Assessment of the effectiveness of tuberculosis control strategies requires the periodic measurement of M. tuberculosis transmission in populations, which is notoriously difficult. One well-established method is to measure the prevalence of infectious pulmonary tuberculosis in the population which is then repeated at a second time point after a period of ‘intervention’, such as scale up of the Search-Treat-Prevent strategy of the Zero TB Cities initiative, allowing for a ‘before and after’ comparison. Protocol: The concurrent adult pulmonary tuberculosis prevalence survey (using digital radiography and Xpert MTB/RIF Ultra) and child M. tuberculosis infection survey (using QuantiFERON-TB® Gold Plus) will primarily provide a baseline measure of the burden of adult infectious tuberculosis in Karachi and assess whether a large-scale interferon gamma release assay survey in children aged 2 to 4 years is feasible. The target population for the prevalence survey is comprised of a stratified random sample of all adults aged 15 years and above and all children aged 2 to 4 years resident in four districts in Karachi. The survey procedures and analyses to estimate pulmonary tuberculosis prevalence are based on the World Health Organization methodology for tuberculosis prevalence surveys. Ethics and dissemination: The study protocol has been approved by the Interactive Research Development / The Indus Hospital Research Centre Research Ethics Committee in Karachi, Pakistan and the London School of Hygiene & Tropical Medicine Research Ethics Committee. Due to non-representative sampling in this setting, where a large proportion of the population are illiterate and are reluctant to provide fingerprints due to concerns about personal security, verbal informed consent will be obtained from each eligible participant or guardian. Results will be submitted to international peer-reviewed journals, presented at international conferences and shared with participating communities and with the Provincial and National TB programme.https://wellcomeopenresearch.org/articles/5-159/v1 |
| spellingShingle | Palwasha Y. Khan M. Shariq Paracha Chris Grundy Saadia Saeed Maqboola Dojki Falak Madhani Liesl Page-Shipp Nazia Khursheed Waleed Rabbani Najam Riaz Saira Khowaja Owais Hussain Ali Habib Uzma Khan Katharina Kranzer Rashida A. Ferrand James J. Lewis Aamir J. Khan Katherine L. Fielding Concurrent adult pulmonary tuberculosis prevalence survey using digital radiography and Xpert MTB/RIF Ultra and child interferon-gamma release assay Mycobacterium tuberculosis infection survey in Karachi, Pakistan: a study protocol [version 1; peer review: 2 approved] Wellcome Open Research |
| title | Concurrent adult pulmonary tuberculosis prevalence survey using digital radiography and Xpert MTB/RIF Ultra and child interferon-gamma release assay Mycobacterium tuberculosis infection survey in Karachi, Pakistan: a study protocol [version 1; peer review: 2 approved] |
| title_full | Concurrent adult pulmonary tuberculosis prevalence survey using digital radiography and Xpert MTB/RIF Ultra and child interferon-gamma release assay Mycobacterium tuberculosis infection survey in Karachi, Pakistan: a study protocol [version 1; peer review: 2 approved] |
| title_fullStr | Concurrent adult pulmonary tuberculosis prevalence survey using digital radiography and Xpert MTB/RIF Ultra and child interferon-gamma release assay Mycobacterium tuberculosis infection survey in Karachi, Pakistan: a study protocol [version 1; peer review: 2 approved] |
| title_full_unstemmed | Concurrent adult pulmonary tuberculosis prevalence survey using digital radiography and Xpert MTB/RIF Ultra and child interferon-gamma release assay Mycobacterium tuberculosis infection survey in Karachi, Pakistan: a study protocol [version 1; peer review: 2 approved] |
| title_short | Concurrent adult pulmonary tuberculosis prevalence survey using digital radiography and Xpert MTB/RIF Ultra and child interferon-gamma release assay Mycobacterium tuberculosis infection survey in Karachi, Pakistan: a study protocol [version 1; peer review: 2 approved] |
| title_sort | concurrent adult pulmonary tuberculosis prevalence survey using digital radiography and xpert mtb rif ultra and child interferon gamma release assay mycobacterium tuberculosis infection survey in karachi pakistan a study protocol version 1 peer review 2 approved |
| url | https://wellcomeopenresearch.org/articles/5-159/v1 |
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