Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.
Generally, epithelial cells must organize in three dimensions to form functional tissue sheets. Here we investigate one such sheet, the Drosophila embryonic epidermis, and the morphogenetic processes organizing cells within it. We report that epidermal morphogenesis requires the proper distribution...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-04-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21483653/pdf/?tool=EBI |
| _version_ | 1818845883639267328 |
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| author | Nicole A Kaplan Pamela F Colosimo Xiaoping Liu Nicholas S Tolwinski |
| author_facet | Nicole A Kaplan Pamela F Colosimo Xiaoping Liu Nicholas S Tolwinski |
| author_sort | Nicole A Kaplan |
| collection | DOAJ |
| description | Generally, epithelial cells must organize in three dimensions to form functional tissue sheets. Here we investigate one such sheet, the Drosophila embryonic epidermis, and the morphogenetic processes organizing cells within it. We report that epidermal morphogenesis requires the proper distribution of the apical polarity determinant aPKC. Specifically, we find roles for the kinases GSK3 and aPKC in cellular alignment, asymmetric protein distribution, and adhesion during the development of this polarized tissue. Finally, we propose a model explaining how regulation of aPKC protein levels can reorganize both adhesion and the cytoskeleton. |
| first_indexed | 2024-12-19T05:36:44Z |
| format | Article |
| id | doaj.art-0659ab3de17248208aadb139825d7dfa |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T05:36:44Z |
| publishDate | 2011-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0659ab3de17248208aadb139825d7dfa2022-12-21T20:34:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-04-0164e1861610.1371/journal.pone.0018616Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.Nicole A KaplanPamela F ColosimoXiaoping LiuNicholas S TolwinskiGenerally, epithelial cells must organize in three dimensions to form functional tissue sheets. Here we investigate one such sheet, the Drosophila embryonic epidermis, and the morphogenetic processes organizing cells within it. We report that epidermal morphogenesis requires the proper distribution of the apical polarity determinant aPKC. Specifically, we find roles for the kinases GSK3 and aPKC in cellular alignment, asymmetric protein distribution, and adhesion during the development of this polarized tissue. Finally, we propose a model explaining how regulation of aPKC protein levels can reorganize both adhesion and the cytoskeleton.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21483653/pdf/?tool=EBI |
| spellingShingle | Nicole A Kaplan Pamela F Colosimo Xiaoping Liu Nicholas S Tolwinski Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis. PLoS ONE |
| title | Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis. |
| title_full | Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis. |
| title_fullStr | Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis. |
| title_full_unstemmed | Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis. |
| title_short | Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis. |
| title_sort | complex interactions between gsk3 and apkc in drosophila embryonic epithelial morphogenesis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21483653/pdf/?tool=EBI |
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