Ambispective study of adverse drug reactions in multi-drug resistant tuberculosis patients in Warangal, Telangana
Background: Multidrug-resistant tuberculosis (MDR-TB) has become a global threat concerning to a risk of high mortality with the potential to cause adverse drug reactions (ADRs) which if not managed properly may affect patient compliance, resulting in below par treatment outcome. Aim: The aim of the...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Lung India |
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| Online Access: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2021;volume=38;issue=4;spage=330;epage=337;aulast=Fatima |
| _version_ | 1818618828610863104 |
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| author | Safurah Fatima Maria Fatima Syeda Nagesh Adla Rama Devi |
| author_facet | Safurah Fatima Maria Fatima Syeda Nagesh Adla Rama Devi |
| author_sort | Safurah Fatima |
| collection | DOAJ |
| description | Background: Multidrug-resistant tuberculosis (MDR-TB) has become a global threat concerning to a risk of high mortality with the potential to cause adverse drug reactions (ADRs) which if not managed properly may affect patient compliance, resulting in below par treatment outcome. Aim: The aim of the study was to study, assess, and report the ADRs of patients diagnosed with MDR-TB. Subjects and Methods: An ambispective, observational study was conducted among confirmed cases of MDR-TB patients without any comorbidities during the period of January 2015–December 2018 in patients of age 15 years and above. Statistical Analysis: Data were analyzed descriptively using MS-Excel sheet 2013 and Chi-square test in GraphPad Prism 8.2.1. Results were expressed as either frequency, percentage, or mean ± standard deviation. ADRs were evaluated for causality, severity, and preventability attributes. Results: In the sample size of 400 patients, 236 (ADRs) were reported among 136 patients. The proportion of ADRs was higher in males (P = 0.0001) and in the age group of 36–75 years (P = 0.0211). Most commonly encountered ADRs include nausea and vomiting (35.31%) and arthralgia (14.04%), followed by peripheral neuropathy (8.93%) and giddiness (8.93%). Overall, 53% were of possible category and 60% of moderate level severity and 85% were unpreventable ADRs. Conclusion: Our study included 13 types of ADRs, of which most commonly reported were nausea and vomiting, arthralgia, and peripheral neuropathy and least common were psychosis, nephrotoxicity, and gynecomastia with a higher incidence in males. Majority of ADRs were moderate, unpreventable ADRs and had a possible relationship with the suspected drugs. |
| first_indexed | 2024-12-16T17:27:48Z |
| format | Article |
| id | doaj.art-065a2bcefb6d4636b7ba1103d50f998b |
| institution | Directory Open Access Journal |
| issn | 0970-2113 0974-598X |
| language | English |
| last_indexed | 2024-12-16T17:27:48Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Lung India |
| spelling | doaj.art-065a2bcefb6d4636b7ba1103d50f998b2022-12-21T22:23:00ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2021-01-0138433033710.4103/lungindia.lungindia_118_19Ambispective study of adverse drug reactions in multi-drug resistant tuberculosis patients in Warangal, TelanganaSafurah FatimaMaria Fatima SyedaNagesh AdlaRama DeviBackground: Multidrug-resistant tuberculosis (MDR-TB) has become a global threat concerning to a risk of high mortality with the potential to cause adverse drug reactions (ADRs) which if not managed properly may affect patient compliance, resulting in below par treatment outcome. Aim: The aim of the study was to study, assess, and report the ADRs of patients diagnosed with MDR-TB. Subjects and Methods: An ambispective, observational study was conducted among confirmed cases of MDR-TB patients without any comorbidities during the period of January 2015–December 2018 in patients of age 15 years and above. Statistical Analysis: Data were analyzed descriptively using MS-Excel sheet 2013 and Chi-square test in GraphPad Prism 8.2.1. Results were expressed as either frequency, percentage, or mean ± standard deviation. ADRs were evaluated for causality, severity, and preventability attributes. Results: In the sample size of 400 patients, 236 (ADRs) were reported among 136 patients. The proportion of ADRs was higher in males (P = 0.0001) and in the age group of 36–75 years (P = 0.0211). Most commonly encountered ADRs include nausea and vomiting (35.31%) and arthralgia (14.04%), followed by peripheral neuropathy (8.93%) and giddiness (8.93%). Overall, 53% were of possible category and 60% of moderate level severity and 85% were unpreventable ADRs. Conclusion: Our study included 13 types of ADRs, of which most commonly reported were nausea and vomiting, arthralgia, and peripheral neuropathy and least common were psychosis, nephrotoxicity, and gynecomastia with a higher incidence in males. Majority of ADRs were moderate, unpreventable ADRs and had a possible relationship with the suspected drugs.http://www.lungindia.com/article.asp?issn=0970-2113;year=2021;volume=38;issue=4;spage=330;epage=337;aulast=Fatimaadverse drug reactioncausalitymultidrug resistant tuberculosispreventability assessmentseverity |
| spellingShingle | Safurah Fatima Maria Fatima Syeda Nagesh Adla Rama Devi Ambispective study of adverse drug reactions in multi-drug resistant tuberculosis patients in Warangal, Telangana Lung India adverse drug reaction causality multidrug resistant tuberculosis preventability assessment severity |
| title | Ambispective study of adverse drug reactions in multi-drug resistant tuberculosis patients in Warangal, Telangana |
| title_full | Ambispective study of adverse drug reactions in multi-drug resistant tuberculosis patients in Warangal, Telangana |
| title_fullStr | Ambispective study of adverse drug reactions in multi-drug resistant tuberculosis patients in Warangal, Telangana |
| title_full_unstemmed | Ambispective study of adverse drug reactions in multi-drug resistant tuberculosis patients in Warangal, Telangana |
| title_short | Ambispective study of adverse drug reactions in multi-drug resistant tuberculosis patients in Warangal, Telangana |
| title_sort | ambispective study of adverse drug reactions in multi drug resistant tuberculosis patients in warangal telangana |
| topic | adverse drug reaction causality multidrug resistant tuberculosis preventability assessment severity |
| url | http://www.lungindia.com/article.asp?issn=0970-2113;year=2021;volume=38;issue=4;spage=330;epage=337;aulast=Fatima |
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