Therapeutic targeting with DABIL‐4 depletes myeloid suppressor cells in 4T1 triple‐negative breast cancer model

Therapeutic targeting with DABIL‐4 depletes myeloid suppressor cells in 4T1 triple‐negative breast cancer model

In many solid tumors including triple‐negative breast cancer (TNBC), upregulation of the interleukin‐4 receptor (IL‐4R) has been shown to promote cancer cell proliferation, apoptotic resistance, metastatic potential, and a Th2 response in the tumor microenvironment (TME). Since immunosuppressive cel...

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Bibliographic Details
Main Authors: Sadiya Parveen, Sumit Siddharth, Laurene S. Cheung, Alok Kumar, Jessica Shen, John R. Murphy, Dipali Sharma, William R. Bishai
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Molecular Oncology
Subjects:
DABIL‐4
diphtheria fusion toxin
IL‐4R
myeloid‐derived suppressor cells
triple‐negative breast cancer
tumor‐associated macrophages
Online Access:https://doi.org/10.1002/1878-0261.12938

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