RhoA Signaling in Neurodegenerative Diseases
Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions. RhoA and many of its downstream effector proteins are highly expressed in the nervous system, implying an imp...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/9/1520 |
| _version_ | 1827672890572537856 |
|---|---|
| author | Sissel Ida Schmidt Morten Blaabjerg Kristine Freude Morten Meyer |
| author_facet | Sissel Ida Schmidt Morten Blaabjerg Kristine Freude Morten Meyer |
| author_sort | Sissel Ida Schmidt |
| collection | DOAJ |
| description | Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions. RhoA and many of its downstream effector proteins are highly expressed in the nervous system, implying an important role for RhoA signaling in neurons and glial cells. Indeed, emerging evidence points toward a role of aberrant RhoA signaling in neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. In this review, we summarize the current knowledge of RhoA regulation and downstream cellular functions with an emphasis on the role of RhoA signaling in neurodegenerative diseases and the therapeutic potential of RhoA inhibition in neurodegeneration. |
| first_indexed | 2024-03-10T04:15:37Z |
| format | Article |
| id | doaj.art-065b2a40862047b98f1ef7fcffac13f0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T04:15:37Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-065b2a40862047b98f1ef7fcffac13f02023-11-23T08:00:24ZengMDPI AGCells2073-44092022-05-01119152010.3390/cells11091520RhoA Signaling in Neurodegenerative DiseasesSissel Ida Schmidt0Morten Blaabjerg1Kristine Freude2Morten Meyer3Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, DK-5000 Odense, DenmarkDepartment of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, DK-5000 Odense, DenmarkSection for Pathobiological Sciences, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, DK-1870 Frederiksberg, DenmarkDepartment of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, DK-5000 Odense, DenmarkRas homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions. RhoA and many of its downstream effector proteins are highly expressed in the nervous system, implying an important role for RhoA signaling in neurons and glial cells. Indeed, emerging evidence points toward a role of aberrant RhoA signaling in neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. In this review, we summarize the current knowledge of RhoA regulation and downstream cellular functions with an emphasis on the role of RhoA signaling in neurodegenerative diseases and the therapeutic potential of RhoA inhibition in neurodegeneration.https://www.mdpi.com/2073-4409/11/9/1520Ras homolog gene family member A (RhoA)Rho-associated coiled-coil-containing kinase (ROCK)Parkinson’s diseaseAlzheimer’s diseaseHuntington’s diseaseamyotrophic lateral sclerosis |
| spellingShingle | Sissel Ida Schmidt Morten Blaabjerg Kristine Freude Morten Meyer RhoA Signaling in Neurodegenerative Diseases Cells Ras homolog gene family member A (RhoA) Rho-associated coiled-coil-containing kinase (ROCK) Parkinson’s disease Alzheimer’s disease Huntington’s disease amyotrophic lateral sclerosis |
| title | RhoA Signaling in Neurodegenerative Diseases |
| title_full | RhoA Signaling in Neurodegenerative Diseases |
| title_fullStr | RhoA Signaling in Neurodegenerative Diseases |
| title_full_unstemmed | RhoA Signaling in Neurodegenerative Diseases |
| title_short | RhoA Signaling in Neurodegenerative Diseases |
| title_sort | rhoa signaling in neurodegenerative diseases |
| topic | Ras homolog gene family member A (RhoA) Rho-associated coiled-coil-containing kinase (ROCK) Parkinson’s disease Alzheimer’s disease Huntington’s disease amyotrophic lateral sclerosis |
| url | https://www.mdpi.com/2073-4409/11/9/1520 |
| work_keys_str_mv | AT sisselidaschmidt rhoasignalinginneurodegenerativediseases AT mortenblaabjerg rhoasignalinginneurodegenerativediseases AT kristinefreude rhoasignalinginneurodegenerativediseases AT mortenmeyer rhoasignalinginneurodegenerativediseases |