RhoA Signaling in Neurodegenerative Diseases

RhoA Signaling in Neurodegenerative Diseases

Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions. RhoA and many of its downstream effector proteins are highly expressed in the nervous system, implying an imp...

Bibliografski detalji
Glavni autori:	Sissel Ida Schmidt, Morten Blaabjerg, Kristine Freude, Morten Meyer
Format:	Članak
Jezik:	English
Izdano:	MDPI AG 2022-05-01
Serija:	Cells
Teme:	Ras homolog gene family member A (RhoA) Rho-associated coiled-coil-containing kinase (ROCK) Parkinson’s disease Alzheimer’s disease Huntington’s disease amyotrophic lateral sclerosis
Online pristup:	https://www.mdpi.com/2073-4409/11/9/1520

Slični predmeti

Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension
od: Wei-Hua Liu, i dr.
Izdano: (2018-04-01)

Electroacupuncture improves retinal function in myopia Guinea pigs probably via inhibition of the RhoA/ROCK2 signaling pathway
od: Yijie Liu, i dr.
Izdano: (2024-08-01)

Effect of alpha-linolenic acid on aminoglycoside nephrotoxicity and RhoA/Rho-kinase pathway in kidney
od: Percin Pazarci, i dr.
Izdano: (2024-10-01)

Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity
od: Cátia Domingos, i dr.
Izdano: (2023-01-01)

Pathogenic single nucleotide polymorphisms in RhoA gene: Insights into structural and functional impacts on RhoA-PLD1 interaction through molecular dynamics simulation
od: Mahbub Hasan, i dr.
Izdano: (2024-01-01)

Potential role of RhoA GTPase regulation in type interferon signaling in systemic lupus erythematosus
od: Wei Fan, i dr.
Izdano: (2024-01-01)

Depletion of the Rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signaling
od: Erik Wåhlén, i dr.
Izdano: (2024-12-01)

Molecular Mechanisms of Alzheimer’s Disease Induced by Amyloid-β and Tau Phosphorylation Along with RhoA Activity: Perspective of RhoA/Rho-Associated Protein Kinase Inhibitors for Neuronal Therapy
od: Eun Hee Ahn, i dr.
Izdano: (2025-01-01)

RhoA Signaling in Immune Cell Response and Cardiac Disease
od: Lucia Sophie Kilian, i dr.
Izdano: (2021-07-01)

Inhibition of RhoA/Rho kinase signaling pathway by fasudil protects against kainic acid‐induced neurite injury
od: Yingchun Xiang, i dr.
Izdano: (2021-08-01)

RhoA suppresses pseudorabies virus replication in vitro
od: Xin-Man Li, i dr.
Izdano: (2023-11-01)

RhoA as a Key Regulator of Innate and Adaptive Immunity
od: Matthias Bros, i dr.
Izdano: (2019-07-01)

RhoA/ROCK2 signaling pathway regulates Mn-induced alterations in tight junction proteins leading to cognitive dysfunction in mice
od: Yan Ma, i dr.
Izdano: (2025-01-01)

HIF-1α dependent RhoA as a novel therapeutic target to regulate rheumatoid arthritis fibroblast-like synoviocytes migration in vitro and in vivo
od: Jianhai Chen, i dr.
Izdano: (2023-05-01)

Melatonin regulates microglial polarization to M2 cell via RhoA/ROCK signaling pathway in epilepsy
od: Pingping Li, i dr.
Izdano: (2023-06-01)

A Novel Single-Color FRET Sensor for Rho-Kinase Reveals Calcium-Dependent Activation of RhoA and ROCK
od: Allison E. Mancini, i dr.
Izdano: (2024-10-01)

The myosin and RhoGAP MYO9B influences osteocyte dendrite growth and responses to mechanical stimuli
od: Beth S. Lee, i dr.
Izdano: (2023-08-01)

The mevalonate pathway promotes the metastasis of osteosarcoma by regulating YAP1 activity via RhoA
od: Xing Du, i dr.
Izdano: (2022-05-01)

RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling
od: Jirong Wang, i dr.
Izdano: (2023-04-01)

The Protective Effect of Simvastatin on the Systolic Function of the Heart in the Model of Acute Ischemia and Reperfusion Is Due to Inhibition of the RhoA Pathway and Independent of Reduction of MMP-2 Activity
od: Monika Skrzypiec-Spring, i dr.
Izdano: (2022-09-01)

RhoA- and Actin-Dependent Functions of Macrophages from the Rodent Cardiac Transplantation Model Perspective -Timing Is the Essence
od: Malgorzata Kloc, i dr.
Izdano: (2021-01-01)

Paeoniflorin inhibits lipopolysaccharide-induced inflammation in LO2 cells by regulating RhoA/NLRP3 pathway
od: Haixia Liu, i dr.
Izdano: (2021-04-01)

PLK1 phosphorylates RhoGDI1 and promotes cancer cell migration and invasion
od: Jeewon Lim, i dr.
Izdano: (2024-02-01)

RETRACTED: Pard3 suppresses glioma invasion by regulating RhoA through atypical protein kinase C/NF‐κB signaling
od: Junjun Li, i dr.
Izdano: (2019-05-01)

An Anti-Invasive Role for Mdmx through the RhoA GTPase under the Control of the NEDD8 Pathway
od: Lara J. Bou Malhab, i dr.
Izdano: (2024-09-01)

Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles
od: Shidong Shan, i dr.
Izdano: (2023-10-01)

Inhibition of RhoA/ROCK signalling pathway activity improves neural damage and cognitive deficits in the fluorosis model
od: Chen Lingli, i dr.
Izdano: (2023-11-01)

RhoA/ROCK/GSK3β Signaling: A Keystone in Understanding Alzheimer’s Disease
od: Milan M. Medd, i dr.
Izdano: (2025-02-01)

RhoA/Rock activation represents a new mechanism for inactivating Wnt/β-catenin signaling in the aging-associated bone loss
od: Wei Shi, i dr.
Izdano: (2021-03-01)

The RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory Signaling in Immortalized and Primary Microglia
od: Elliot J. Glotfelty, i dr.
Izdano: (2023-05-01)

GEF-H1 Transduces FcεRI Signaling in Mast Cells to Activate RhoA and Focal Adhesion Formation during Exocytosis
od: Yitian Guo, i dr.
Izdano: (2023-02-01)

Role of Rho-associated kinases and their inhibitor fasudil in neurodegenerative diseases
od: Qiuyan Ye, i dr.
Izdano: (2024-11-01)

Folic acid promotes myoblast migration through Folr1 interacting with RhoA and improves skeletal muscle regeneration
od: Shuang Li, i dr.
Izdano: (2024-01-01)

Fluoride-induced hypertension by regulating RhoA/ROCK pathway and phenotypic transformation of vascular smooth muscle cells: In vitro and in vivo evidence
od: Wenjing Yang, i dr.
Izdano: (2024-08-01)

Combined RhoA morpholino and ChABC treatment protects identified lamprey neurons from retrograde apoptosis after spinal cord injury
od: Jianli Hu, i dr.
Izdano: (2023-12-01)

The Complex of p-Tyr42 RhoA and p-p65/RelA in Response to LPS Regulates the Expression of Phosphoglycerate Kinase 1
od: Oyungerel Dogsom, i dr.
Izdano: (2023-12-01)

Structural Mechanisms and Drug Discovery Prospects of Rho GTPases
od: Cameron C. Smithers, i dr.
Izdano: (2016-06-01)

RhoA-ROCK2 signaling possesses complex pathophysiological functions in cancer progression and shows promising therapeutic potential
od: Yidi Ning, i dr.
Izdano: (2024-10-01)

RhoA/ROCK Pathway Is Upregulated in Experimental Autoimmune Myocarditis and Is Inhibited by Simvastatin at the Stage of Myosin Light Chain Phosphorylation
od: Monika Skrzypiec-Spring, i dr.
Izdano: (2024-03-01)

Subcortical T1-Rho MRI Abnormalities in Juvenile-Onset Huntington’s Disease
od: Alexander V. Tereshchenko, i dr.
Izdano: (2020-08-01)