RhoA Signaling in Neurodegenerative Diseases

RhoA Signaling in Neurodegenerative Diseases

Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions. RhoA and many of its downstream effector proteins are highly expressed in the nervous system, implying an imp...

Full description

Bibliographic Details
Main Authors:	Sissel Ida Schmidt, Morten Blaabjerg, Kristine Freude, Morten Meyer
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Series:	Cells
Subjects:	Ras homolog gene family member A (RhoA) Rho-associated coiled-coil-containing kinase (ROCK) Parkinson’s disease Alzheimer’s disease Huntington’s disease amyotrophic lateral sclerosis
Online Access:	https://www.mdpi.com/2073-4409/11/9/1520

Similar Items

Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension
by: Wei-Hua Liu, et al.
Published: (2018-04-01)

Electroacupuncture improves retinal function in myopia Guinea pigs probably via inhibition of the RhoA/ROCK2 signaling pathway
by: Yijie Liu, et al.
Published: (2024-08-01)

Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves’ Ophthalmopathy-Derived Orbital Fibroblasts via RhoA-Mediated ERK and p38 Signaling Pathways
by: Yi-Hsuan Wei, et al.
Published: (2021-02-01)

Effect of alpha-linolenic acid on aminoglycoside nephrotoxicity and RhoA/Rho-kinase pathway in kidney
by: Percin Pazarci, et al.
Published: (2024-10-01)

RhoA/Rho‐kinases in asthma: from pathogenesis to therapeutic targets
by: Yan Zhang, et al.
Published: (2020-01-01)

Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity
by: Cátia Domingos, et al.
Published: (2023-01-01)

Alendronate prevents angiotensin II-induced collagen I production through geranylgeranylation-dependent RhoA/Rho kinase activation in cardiac fibroblasts
by: Yang Ye, et al.
Published: (2015-12-01)

Pathogenic single nucleotide polymorphisms in RhoA gene: Insights into structural and functional impacts on RhoA-PLD1 interaction through molecular dynamics simulation
by: Mahbub Hasan, et al.
Published: (2024-01-01)

Potential role of RhoA GTPase regulation in type interferon signaling in systemic lupus erythematosus
by: Wei Fan, et al.
Published: (2024-01-01)

RhoA/Rho kinase in spinal cord injury
by: Xiangbing Wu, et al.
Published: (2016-01-01)

Depletion of the Rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signaling
by: Erik Wåhlén, et al.
Published: (2024-12-01)

Enhancement of the RhoA/Rho kinase pathway is associated with stress‐related erectile dysfunction in a restraint water immersion stress model
by: Taiki Mori, et al.
Published: (2021-10-01)

Molecular Mechanisms of Alzheimer’s Disease Induced by Amyloid-β and Tau Phosphorylation Along with RhoA Activity: Perspective of RhoA/Rho-Associated Protein Kinase Inhibitors for Neuronal Therapy
by: Eun Hee Ahn, et al.
Published: (2025-01-01)

Cytokinetic diversity in mammalian cells is revealed by the characterization of endogenous anillin, Ect2 and RhoA
by: Mathieu C. Husser, et al.
Published: (2022-11-01)

RhoA Signaling in Immune Cell Response and Cardiac Disease
by: Lucia Sophie Kilian, et al.
Published: (2021-07-01)

Inhibition of RhoA/Rho kinase signaling pathway by fasudil protects against kainic acid‐induced neurite injury
by: Yingchun Xiang, et al.
Published: (2021-08-01)

Relationship between the expression of ARHGAP25 and RhoA in non-small cell lung cancer and vasculogenic mimicry
by: Fan Shi, et al.
Published: (2022-10-01)

Inhibition of U‐II/UT signaling ameliorates cystitis‐associated bladder hyperactivity by targeting the RhoA/Rho‐kinase pathway
by: Qian Liu, et al.
Published: (2022-09-01)

The Role of RhoA, RhoB and RhoC GTPases in Cell Morphology, Proliferation and Migration in Human Cytomegalovirus (HCMV) Infected Glioblastoma Cells
by: Melpomeni Tseliou, et al.
Published: (2016-01-01)

Cytotoxicity of amide-linked local anesthetics on melanoma cells via inhibition of Ras and RhoA signaling independent of sodium channel blockade
by: Qinghong Zheng, et al.
Published: (2020-02-01)

RhoA suppresses pseudorabies virus replication in vitro
by: Xin-Man Li, et al.
Published: (2023-11-01)

RhoA as a Key Regulator of Innate and Adaptive Immunity
by: Matthias Bros, et al.
Published: (2019-07-01)

RhoA/ROCK2 signaling pathway regulates Mn-induced alterations in tight junction proteins leading to cognitive dysfunction in mice
by: Yan Ma, et al.
Published: (2025-01-01)

Multifaceted Rho GTPase Signaling at the Endomembranes
by: Santosh Phuyal, et al.
Published: (2019-07-01)

MicroRNA-141 Inhibits the Proliferation of Penile Cavernous Smooth Muscle Cells Associated with Down-Regulation of the Rhoa/Rho Kinase Signaling Pathway
by: Ying Zhang, et al.
Published: (2018-07-01)

RhoA improves cryopreservation of rooster sperm through the Rho/RhoA-associated kinase/cofilin pathway
by: Nuo Heng, et al.
Published: (2022-10-01)

HIF-1α dependent RhoA as a novel therapeutic target to regulate rheumatoid arthritis fibroblast-like synoviocytes migration in vitro and in vivo
by: Jianhai Chen, et al.
Published: (2023-05-01)

VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells
by: Ayumi Yoshida, et al.
Published: (2015-09-01)

Melatonin regulates microglial polarization to M2 cell via RhoA/ROCK signaling pathway in epilepsy
by: Pingping Li, et al.
Published: (2023-06-01)

Rho GTPases in ameloblast differentiation
by: Keishi Otsu, et al.
Published: (2016-05-01)

A Novel Single-Color FRET Sensor for Rho-Kinase Reveals Calcium-Dependent Activation of RhoA and ROCK
by: Allison E. Mancini, et al.
Published: (2024-10-01)

Angiotensin II Silencing Alleviates Erectile Dysfunction Through Down-Regulating the Rhoa/Rho Kinase Signaling Pathway in Rats with Diabetes Mellitus
by: Ying Zhang, et al.
Published: (2018-01-01)

Rho1 activation recapitulates early gastrulation events in the ventral, but not dorsal, epithelium of Drosophila embryos
by: Ashley Rich, et al.
Published: (2020-11-01)

The myosin and RhoGAP MYO9B influences osteocyte dendrite growth and responses to mechanical stimuli
by: Beth S. Lee, et al.
Published: (2023-08-01)

Statins Stimulate In Vitro Membrane FasL Expression and Lymphocyte Apoptosis through RhoA/ROCK Pathway in Murine Melanoma Cells
by: Guillaume Sarrabayrouse, et al.
Published: (2007-12-01)

The mevalonate pathway promotes the metastasis of osteosarcoma by regulating YAP1 activity via RhoA
by: Xing Du, et al.
Published: (2022-05-01)

RhoA enhances osteosarcoma resistance to MPPa-PDT via the Hippo/YAP signaling pathway
by: Fangbiao Zhan, et al.
Published: (2021-10-01)

Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody
by: Astrid Rohrbeck, et al.
Published: (2016-04-01)

RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling
by: Jirong Wang, et al.
Published: (2023-04-01)

Oxidized LDL signals through Rho-GTPase to induce endothelial cell stiffening and promote capillary formation[S]
by: Myung-Jin Oh, et al.
Published: (2016-05-01)