Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: a CAN-BIND 1 report
Abstract The pathophysiology of major depressive disorder (MDD) encompasses an array of changes at molecular and neurobiological levels. As chronic stress promotes neurotoxicity there are alterations in the expression of genes and gene-regulatory molecules. The hippocampus is particularly sensitive...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-09-01
|
| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-021-01592-4 |
| _version_ | 1818607885352960000 |
|---|---|
| author | Antoine Yrondi Laura M. Fiori Nikita Nogovitsyn Stefanie Hassel Jean François Théroux Zahia Aouabed Benicio N. Frey Raymond W. Lam Roumen Milev Daniel J. Müller Jane A. Foster Claudio Soares Susan Rotzinger Stephen C. Strother Glenda M. MacQueen Stephen R. Arnott Andrew D. Davis Mojdeh Zamyadi Jacqueline Harris Sidney H. Kennedy Gustavo Turecki |
| author_facet | Antoine Yrondi Laura M. Fiori Nikita Nogovitsyn Stefanie Hassel Jean François Théroux Zahia Aouabed Benicio N. Frey Raymond W. Lam Roumen Milev Daniel J. Müller Jane A. Foster Claudio Soares Susan Rotzinger Stephen C. Strother Glenda M. MacQueen Stephen R. Arnott Andrew D. Davis Mojdeh Zamyadi Jacqueline Harris Sidney H. Kennedy Gustavo Turecki |
| author_sort | Antoine Yrondi |
| collection | DOAJ |
| description | Abstract The pathophysiology of major depressive disorder (MDD) encompasses an array of changes at molecular and neurobiological levels. As chronic stress promotes neurotoxicity there are alterations in the expression of genes and gene-regulatory molecules. The hippocampus is particularly sensitive to the effects of stress and its posterior volumes can deliver clinically valuable information about the outcomes of antidepressant treatment. In the present work, we analyzed individuals with MDD (N = 201) and healthy controls (HC = 104), as part of the CAN-BIND-1 study. We used magnetic resonance imaging (MRI) to measure hippocampal volumes, evaluated gene expression with RNA sequencing, and assessed DNA methylation with the (Infinium MethylationEpic Beadchip), in order to investigate the association between hippocampal volume and both RNA expression and DNA methylation. We identified 60 RNAs which were differentially expressed between groups. Of these, 21 displayed differential methylation, and seven displayed a correlation between methylation and expression. We found a negative association between expression of Brain Abundant Membrane Attached Signal Protein 1 antisense 1 RNA (BASP1-AS1) and right hippocampal tail volume in the MDD group (β = −0.218, p = 0.021). There was a moderating effect of the duration of the current episode on the association between the expression of BASP1-AS1 and right hippocampal tail volume in the MDD group (β = −0.48, 95% C.I. [−0.80, −0.16]. t = −2.95 p = 0.004). In conclusion, we found that overexpression of BASP1-AS1 was correlated with DNA methylation, and was negatively associated with right tail hippocampal volume in MDD. |
| first_indexed | 2024-12-16T14:33:51Z |
| format | Article |
| id | doaj.art-065d0f0350c1425896a0f36f31046e58 |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-12-16T14:33:51Z |
| publishDate | 2021-09-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-065d0f0350c1425896a0f36f31046e582022-12-21T22:28:08ZengNature Publishing GroupTranslational Psychiatry2158-31882021-09-011111710.1038/s41398-021-01592-4Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: a CAN-BIND 1 reportAntoine Yrondi0Laura M. Fiori1Nikita Nogovitsyn2Stefanie Hassel3Jean François Théroux4Zahia Aouabed5Benicio N. Frey6Raymond W. Lam7Roumen Milev8Daniel J. Müller9Jane A. Foster10Claudio Soares11Susan Rotzinger12Stephen C. Strother13Glenda M. MacQueen14Stephen R. Arnott15Andrew D. Davis16Mojdeh Zamyadi17Jacqueline Harris18Sidney H. Kennedy19Gustavo Turecki20McGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill UniversityMcGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill UniversityDepartment of Psychiatry, Cumming School of Medicine, University of CalgaryDepartment of Psychiatry, Cumming School of Medicine, University of CalgaryMcGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill UniversityMcGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill UniversityDepartment of Psychiatry & Behavioural Neurosciences, McMaster University and St Joseph’s Healthcare HamiltonDepartment of Psychiatry, University of British ColumbiaDepartment of Psychiatry at Queens Providence Care HospitalDepartment of Psychiatry, University Health Network, Krembil Research Institute, University of TorontoDepartment of Psychiatry & Behavioural Neurosciences, McMaster University and St Joseph’s Healthcare HamiltonSt Michael’s Hospital, Li Ka Shing Knowledge Institute, Centre for Depression and Suicide StudiesDepartment of Psychiatry, University Health Network, Krembil Research Institute, University of TorontoRotman Research Institute, Baycrest Health Sciences; Department of Medical Biophysics, University of TorontoHotchkiss Brain Institute, University of CalgaryRotman Research Institute, Baycrest Health Sciences; Department of Medical Biophysics, University of TorontoRotman Research Institute, Baycrest Health Sciences; Department of Medical Biophysics, University of TorontoRotman Research Institute, Baycrest Health Sciences; Department of Medical Biophysics, University of TorontoDepartment of Computer Science, University of AlbertaDepartment of Psychiatry, University Health Network, Krembil Research Institute, University of TorontoMcGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry, McGill UniversityAbstract The pathophysiology of major depressive disorder (MDD) encompasses an array of changes at molecular and neurobiological levels. As chronic stress promotes neurotoxicity there are alterations in the expression of genes and gene-regulatory molecules. The hippocampus is particularly sensitive to the effects of stress and its posterior volumes can deliver clinically valuable information about the outcomes of antidepressant treatment. In the present work, we analyzed individuals with MDD (N = 201) and healthy controls (HC = 104), as part of the CAN-BIND-1 study. We used magnetic resonance imaging (MRI) to measure hippocampal volumes, evaluated gene expression with RNA sequencing, and assessed DNA methylation with the (Infinium MethylationEpic Beadchip), in order to investigate the association between hippocampal volume and both RNA expression and DNA methylation. We identified 60 RNAs which were differentially expressed between groups. Of these, 21 displayed differential methylation, and seven displayed a correlation between methylation and expression. We found a negative association between expression of Brain Abundant Membrane Attached Signal Protein 1 antisense 1 RNA (BASP1-AS1) and right hippocampal tail volume in the MDD group (β = −0.218, p = 0.021). There was a moderating effect of the duration of the current episode on the association between the expression of BASP1-AS1 and right hippocampal tail volume in the MDD group (β = −0.48, 95% C.I. [−0.80, −0.16]. t = −2.95 p = 0.004). In conclusion, we found that overexpression of BASP1-AS1 was correlated with DNA methylation, and was negatively associated with right tail hippocampal volume in MDD.https://doi.org/10.1038/s41398-021-01592-4 |
| spellingShingle | Antoine Yrondi Laura M. Fiori Nikita Nogovitsyn Stefanie Hassel Jean François Théroux Zahia Aouabed Benicio N. Frey Raymond W. Lam Roumen Milev Daniel J. Müller Jane A. Foster Claudio Soares Susan Rotzinger Stephen C. Strother Glenda M. MacQueen Stephen R. Arnott Andrew D. Davis Mojdeh Zamyadi Jacqueline Harris Sidney H. Kennedy Gustavo Turecki Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: a CAN-BIND 1 report Translational Psychiatry |
| title | Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: a CAN-BIND 1 report |
| title_full | Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: a CAN-BIND 1 report |
| title_fullStr | Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: a CAN-BIND 1 report |
| title_full_unstemmed | Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: a CAN-BIND 1 report |
| title_short | Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: a CAN-BIND 1 report |
| title_sort | association between the expression of lncrna basp as1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder a can bind 1 report |
| url | https://doi.org/10.1038/s41398-021-01592-4 |
| work_keys_str_mv | AT antoineyrondi associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT lauramfiori associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT nikitanogovitsyn associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT stefaniehassel associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT jeanfrancoistheroux associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT zahiaaouabed associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT benicionfrey associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT raymondwlam associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT roumenmilev associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT danieljmuller associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT janeafoster associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT claudiosoares associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT susanrotzinger associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT stephencstrother associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT glendammacqueen associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT stephenrarnott associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT andrewddavis associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT mojdehzamyadi associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT jacquelineharris associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT sidneyhkennedy associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report AT gustavoturecki associationbetweentheexpressionoflncrnabaspas1andvolumeofrighthippocampaltailmoderatedbyepisodedurationinmajordepressivedisorderacanbind1report |