Clinical Efficacy of Therapy with Recombinant Human Interferon α1b in Hand, Foot, and Mouth Disease with Enterovirus 71 Infection.
UNLABELLED:A rapid expansion of HFMD with enterovirus 71 infection outbreaks has occurred and caused deaths in recent years in China, but no vaccine or antiviral drug is currently available for EV71 infection. This study aims to provide treatment programs for HFMD patients. We conducted a randomized...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4755579?pdf=render |
| _version_ | 1811207018097147904 |
|---|---|
| author | Xueyong Huang Xi Zhang Fang Wang Haiyan Wei Hong Ma Meili Sui Jie Lu Huaili Wang J Stephen Dumler Guangyao Sheng Bianli Xu |
| author_facet | Xueyong Huang Xi Zhang Fang Wang Haiyan Wei Hong Ma Meili Sui Jie Lu Huaili Wang J Stephen Dumler Guangyao Sheng Bianli Xu |
| author_sort | Xueyong Huang |
| collection | DOAJ |
| description | UNLABELLED:A rapid expansion of HFMD with enterovirus 71 infection outbreaks has occurred and caused deaths in recent years in China, but no vaccine or antiviral drug is currently available for EV71 infection. This study aims to provide treatment programs for HFMD patients. We conducted a randomized, double-blind, controlled trial and evaluated clinical efficacy of therapy with rHuIFN-α1b in HFMD patients with EV71 infection. There were statistical differences in outcomes including the fever clearance time, healing time of typical skin or oral mucosa lesions, and EV71 viral load of the HFMD patients among ultrasonic aerosol inhalation group, intramuscular injection group and control group. rHuIFN-α1b therapy reduced the fever clearance time, healing time of typical skin or oral mucosa lesions, and EV71 viral load in children with HFMD. TRIAL REGISTRATION:Chinese Clinical Trial Registry ChiCTR-TRC-14005153. |
| first_indexed | 2024-04-12T03:57:51Z |
| format | Article |
| id | doaj.art-065dd3697d38489ab62e7608a8aa7309 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T03:57:51Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-065dd3697d38489ab62e7608a8aa73092022-12-22T03:48:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014890710.1371/journal.pone.0148907Clinical Efficacy of Therapy with Recombinant Human Interferon α1b in Hand, Foot, and Mouth Disease with Enterovirus 71 Infection.Xueyong HuangXi ZhangFang WangHaiyan WeiHong MaMeili SuiJie LuHuaili WangJ Stephen DumlerGuangyao ShengBianli XuUNLABELLED:A rapid expansion of HFMD with enterovirus 71 infection outbreaks has occurred and caused deaths in recent years in China, but no vaccine or antiviral drug is currently available for EV71 infection. This study aims to provide treatment programs for HFMD patients. We conducted a randomized, double-blind, controlled trial and evaluated clinical efficacy of therapy with rHuIFN-α1b in HFMD patients with EV71 infection. There were statistical differences in outcomes including the fever clearance time, healing time of typical skin or oral mucosa lesions, and EV71 viral load of the HFMD patients among ultrasonic aerosol inhalation group, intramuscular injection group and control group. rHuIFN-α1b therapy reduced the fever clearance time, healing time of typical skin or oral mucosa lesions, and EV71 viral load in children with HFMD. TRIAL REGISTRATION:Chinese Clinical Trial Registry ChiCTR-TRC-14005153.http://europepmc.org/articles/PMC4755579?pdf=render |
| spellingShingle | Xueyong Huang Xi Zhang Fang Wang Haiyan Wei Hong Ma Meili Sui Jie Lu Huaili Wang J Stephen Dumler Guangyao Sheng Bianli Xu Clinical Efficacy of Therapy with Recombinant Human Interferon α1b in Hand, Foot, and Mouth Disease with Enterovirus 71 Infection. PLoS ONE |
| title | Clinical Efficacy of Therapy with Recombinant Human Interferon α1b in Hand, Foot, and Mouth Disease with Enterovirus 71 Infection. |
| title_full | Clinical Efficacy of Therapy with Recombinant Human Interferon α1b in Hand, Foot, and Mouth Disease with Enterovirus 71 Infection. |
| title_fullStr | Clinical Efficacy of Therapy with Recombinant Human Interferon α1b in Hand, Foot, and Mouth Disease with Enterovirus 71 Infection. |
| title_full_unstemmed | Clinical Efficacy of Therapy with Recombinant Human Interferon α1b in Hand, Foot, and Mouth Disease with Enterovirus 71 Infection. |
| title_short | Clinical Efficacy of Therapy with Recombinant Human Interferon α1b in Hand, Foot, and Mouth Disease with Enterovirus 71 Infection. |
| title_sort | clinical efficacy of therapy with recombinant human interferon α1b in hand foot and mouth disease with enterovirus 71 infection |
| url | http://europepmc.org/articles/PMC4755579?pdf=render |
| work_keys_str_mv | AT xueyonghuang clinicalefficacyoftherapywithrecombinanthumaninterferona1binhandfootandmouthdiseasewithenterovirus71infection AT xizhang clinicalefficacyoftherapywithrecombinanthumaninterferona1binhandfootandmouthdiseasewithenterovirus71infection AT fangwang clinicalefficacyoftherapywithrecombinanthumaninterferona1binhandfootandmouthdiseasewithenterovirus71infection AT haiyanwei clinicalefficacyoftherapywithrecombinanthumaninterferona1binhandfootandmouthdiseasewithenterovirus71infection AT hongma clinicalefficacyoftherapywithrecombinanthumaninterferona1binhandfootandmouthdiseasewithenterovirus71infection AT meilisui clinicalefficacyoftherapywithrecombinanthumaninterferona1binhandfootandmouthdiseasewithenterovirus71infection AT jielu clinicalefficacyoftherapywithrecombinanthumaninterferona1binhandfootandmouthdiseasewithenterovirus71infection AT huailiwang clinicalefficacyoftherapywithrecombinanthumaninterferona1binhandfootandmouthdiseasewithenterovirus71infection AT jstephendumler clinicalefficacyoftherapywithrecombinanthumaninterferona1binhandfootandmouthdiseasewithenterovirus71infection AT guangyaosheng clinicalefficacyoftherapywithrecombinanthumaninterferona1binhandfootandmouthdiseasewithenterovirus71infection AT bianlixu clinicalefficacyoftherapywithrecombinanthumaninterferona1binhandfootandmouthdiseasewithenterovirus71infection |