Effect of iron supplementation in pregnant women with high hemoglobin on neonatal jaundice: A randomized double-blind clinical trial
Introduction: Prescribing routine Iron supplementation during pregnancy has been done regardless of their need for many years. Considering the possibility of adverse pregnancy outcomes with unnecessary consumption of iron supplementation in pregnant women, this study was performed with aim to assess...
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| Format: | Article |
| Language: | fas |
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Mashhad University of Medical Sciences
2019-06-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
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| Online Access: | https://ijogi.mums.ac.ir/article_13441_845d26c2118be6555ca57248c14b71a3.pdf |
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| author | Leila Alizadeh Leili Salehi Zahra Mehraban Mani Ramzi |
| author_facet | Leila Alizadeh Leili Salehi Zahra Mehraban Mani Ramzi |
| author_sort | Leila Alizadeh |
| collection | DOAJ |
| description | Introduction: Prescribing routine Iron supplementation during pregnancy has been done regardless of their need for many years. Considering the possibility of adverse pregnancy outcomes with unnecessary consumption of iron supplementation in pregnant women, this study was performed with aim to assess the effect of iron supplementation in pregnant women with high hemoglobin on neonatal jaundice.
Methods: This double-blind controlled randomized clinical trial was performed on 140 nonsmoker healthy pregnant women with gestational age of 14-18weeks and singleton pregnancy with Hb > 13.2 g/dL and ferritin > 15 μg/l in Ardabil during 2016-17. Mothers were randomly assigned to 50 mg ferrous sulfate and placebo groups from 20th weeks of pregnancy. Also, 24 hour after delivery, the neonates were assessed in terms of bilirubin level (by photometric method using BT3500 device) and jaundice. Data were analyzed by SPSS software (version 16) and independent t-test, Chi-square, and exact fisher test. P < 0.05 was considered statistically significant.
Results: There was significant difference between two groups in Hb (P = 0.03) and ferritin (P = 0.04) levels after the intervention, but no significant difference was found between two groups in the incidence of anemia (Hb<11 g/dl) (P < 0.001). In addition, the incidence of neonatal jaundice was more in interventional group than placebo (P=0.005). The incidence of neonatal jaundice was associated with first-trimester ferritin (P=0.01).
Conclusion: Iron supplementation in pregnant women with Hb > 13.2 g/dl is associated with increased risk of neonatal jaundice; therefore, routine prescribing of iron supplementation should be done with caution in pregnancy. |
| first_indexed | 2024-04-13T15:33:54Z |
| format | Article |
| id | doaj.art-065e6a8b4d3e4c6bbb24d04be4a23e1f |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-13T15:33:54Z |
| publishDate | 2019-06-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-065e6a8b4d3e4c6bbb24d04be4a23e1f2022-12-22T02:41:19ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632019-06-01224182410.22038/ijogi.2019.1344113441Effect of iron supplementation in pregnant women with high hemoglobin on neonatal jaundice: A randomized double-blind clinical trialLeila Alizadeh0Leili Salehi1Zahra Mehraban2Mani Ramzi3Instructor, Department of Midwifery, Ardabil Branch, Islamic Azad University, Ardabil, Iran.Associate Professor, Department of Health Education and Health Development, Health, Safety and Environment Research Center, School of Health, Alborz University of Medical Sciences, Karaj, Iran.PhD Student of Reproductive Biology, Ardabil Branch, Islamic Azad University, Ardabil, Iran.Professor, Department of Blood and Oncology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Introduction: Prescribing routine Iron supplementation during pregnancy has been done regardless of their need for many years. Considering the possibility of adverse pregnancy outcomes with unnecessary consumption of iron supplementation in pregnant women, this study was performed with aim to assess the effect of iron supplementation in pregnant women with high hemoglobin on neonatal jaundice. Methods: This double-blind controlled randomized clinical trial was performed on 140 nonsmoker healthy pregnant women with gestational age of 14-18weeks and singleton pregnancy with Hb > 13.2 g/dL and ferritin > 15 μg/l in Ardabil during 2016-17. Mothers were randomly assigned to 50 mg ferrous sulfate and placebo groups from 20th weeks of pregnancy. Also, 24 hour after delivery, the neonates were assessed in terms of bilirubin level (by photometric method using BT3500 device) and jaundice. Data were analyzed by SPSS software (version 16) and independent t-test, Chi-square, and exact fisher test. P < 0.05 was considered statistically significant. Results: There was significant difference between two groups in Hb (P = 0.03) and ferritin (P = 0.04) levels after the intervention, but no significant difference was found between two groups in the incidence of anemia (Hb<11 g/dl) (P < 0.001). In addition, the incidence of neonatal jaundice was more in interventional group than placebo (P=0.005). The incidence of neonatal jaundice was associated with first-trimester ferritin (P=0.01). Conclusion: Iron supplementation in pregnant women with Hb > 13.2 g/dl is associated with increased risk of neonatal jaundice; therefore, routine prescribing of iron supplementation should be done with caution in pregnancy.https://ijogi.mums.ac.ir/article_13441_845d26c2118be6555ca57248c14b71a3.pdfferrous sulfatehemoglobinneonatal jaundicepregnancy |
| spellingShingle | Leila Alizadeh Leili Salehi Zahra Mehraban Mani Ramzi Effect of iron supplementation in pregnant women with high hemoglobin on neonatal jaundice: A randomized double-blind clinical trial Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān ferrous sulfate hemoglobin neonatal jaundice pregnancy |
| title | Effect of iron supplementation in pregnant women with high hemoglobin on neonatal jaundice: A randomized double-blind clinical trial |
| title_full | Effect of iron supplementation in pregnant women with high hemoglobin on neonatal jaundice: A randomized double-blind clinical trial |
| title_fullStr | Effect of iron supplementation in pregnant women with high hemoglobin on neonatal jaundice: A randomized double-blind clinical trial |
| title_full_unstemmed | Effect of iron supplementation in pregnant women with high hemoglobin on neonatal jaundice: A randomized double-blind clinical trial |
| title_short | Effect of iron supplementation in pregnant women with high hemoglobin on neonatal jaundice: A randomized double-blind clinical trial |
| title_sort | effect of iron supplementation in pregnant women with high hemoglobin on neonatal jaundice a randomized double blind clinical trial |
| topic | ferrous sulfate hemoglobin neonatal jaundice pregnancy |
| url | https://ijogi.mums.ac.ir/article_13441_845d26c2118be6555ca57248c14b71a3.pdf |
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