Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression
Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to se...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/11/1551 |
| _version_ | 1797511049603186688 |
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| author | Cornelia Tolg Britney Jodi-Ann Messam James Benjamin McCarthy Andrew Cook Nelson Eva Ann Turley |
| author_facet | Cornelia Tolg Britney Jodi-Ann Messam James Benjamin McCarthy Andrew Cook Nelson Eva Ann Turley |
| author_sort | Cornelia Tolg |
| collection | DOAJ |
| description | Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to sequentially promote then suppress inflammation and fibrosis, a duality in which is featured, and regulated in, wound repair. These essential response-to-injury functions of HA in the microenvironment are hijacked by tumor cells for invasion and avoidance of immune detection. In this review, we first discuss the numerous size-dependent functions of HA and emphasize the multifunctional nature of two of its receptors (CD44 and RHAMM) in regulating the signaling duality of HA in excisional wound healing. This is followed by a discussion of how HA metabolism is de-regulated in malignant progression and how targeting HA might be used to better manage breast cancer progression. |
| first_indexed | 2024-03-10T05:40:52Z |
| format | Article |
| id | doaj.art-065f3a6a375e4378a6b9f9199a8e0190 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T05:40:52Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-065f3a6a375e4378a6b9f9199a8e01902023-11-22T22:32:51ZengMDPI AGBiomolecules2218-273X2021-10-011111155110.3390/biom11111551Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer ProgressionCornelia Tolg0Britney Jodi-Ann Messam1James Benjamin McCarthy2Andrew Cook Nelson3Eva Ann Turley4London Regional Cancer Program, Lawson Health Research Institute, London, ON N6A 5W9, CanadaDepartment Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, CanadaDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USAMasonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USALondon Regional Cancer Program, Lawson Health Research Institute, Department Oncology, Biochemistry and Surgery, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, CanadaSignaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to sequentially promote then suppress inflammation and fibrosis, a duality in which is featured, and regulated in, wound repair. These essential response-to-injury functions of HA in the microenvironment are hijacked by tumor cells for invasion and avoidance of immune detection. In this review, we first discuss the numerous size-dependent functions of HA and emphasize the multifunctional nature of two of its receptors (CD44 and RHAMM) in regulating the signaling duality of HA in excisional wound healing. This is followed by a discussion of how HA metabolism is de-regulated in malignant progression and how targeting HA might be used to better manage breast cancer progression.https://www.mdpi.com/2218-273X/11/11/1551hyaluronanRHAMMCD44wound repairbreast cancer |
| spellingShingle | Cornelia Tolg Britney Jodi-Ann Messam James Benjamin McCarthy Andrew Cook Nelson Eva Ann Turley Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression Biomolecules hyaluronan RHAMM CD44 wound repair breast cancer |
| title | Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression |
| title_full | Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression |
| title_fullStr | Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression |
| title_full_unstemmed | Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression |
| title_short | Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression |
| title_sort | hyaluronan functions in wound repair that are captured to fuel breast cancer progression |
| topic | hyaluronan RHAMM CD44 wound repair breast cancer |
| url | https://www.mdpi.com/2218-273X/11/11/1551 |
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