Clinical course of biliary-type sphincter of Oddi dysfunction: endoscopic sphincterotomy and functional dyspepsia as affecting factors
Background and study aims: The objective of this study was to clarify the effectiveness of treatment selection for biliary-type sphincter of Oddi dysfunction by severe pain frequency and the risk factors for recurrence including the history of functional gastrointestinal disorder. Patients and metho...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-08-01
|
| Series: | Therapeutic Advances in Gastrointestinal Endoscopy |
| Online Access: | https://doi.org/10.1177/2631774519867184 |
| _version_ | 1818527874092630016 |
|---|---|
| author | Hiroyuki Miyatani Hirosato Mashima Masanari Sekine Satohiro Matsumoto |
| author_facet | Hiroyuki Miyatani Hirosato Mashima Masanari Sekine Satohiro Matsumoto |
| author_sort | Hiroyuki Miyatani |
| collection | DOAJ |
| description | Background and study aims: The objective of this study was to clarify the effectiveness of treatment selection for biliary-type sphincter of Oddi dysfunction by severe pain frequency and the risk factors for recurrence including the history of functional gastrointestinal disorder. Patients and methods: Thirty-six sphincter of Oddi dysfunction patients who were confirmed endoscopic retrograde cholangiopancreatography enrolled in this study. Endoscopic sphincterotomy was performed for type I and manometry-confirmed type II sphincter of Oddi dysfunction patients with severe pain (⩾2 times/year; endoscopic sphincterotomy group). Others were treated medically (non-endoscopic sphincterotomy group). Results: The short-term effectiveness rate of endoscopic sphincterotomy was 91%. The final remission rates of the endoscopic sphincterotomy and non-endoscopic sphincterotomy groups were 86% and 100%, respectively. Symptoms relapsed after endoscopic sphincterotomy in 32% of patients. Patients in the endoscopic sphincterotomy and non-endoscopic sphincterotomy groups had or developed functional dyspepsia in 41% and 14%, irritable bowel syndrome in 5% and 14%, and gastroesophageal reflux disorder in 14% and 0%, respectively. History or new onset of functional dyspepsia was related to recurrence on multivariate analysis. The frequency of occurrence of post-endoscopic retrograde cholangiopancreatography pancreatitis and post-endoscopic retrograde cholangiopancreatography cholangitis was high in both groups. Two new occurrences of bile duct stone cases were observed in each group. Conclusion: According to the treatment criteria, endoscopic and medical treatment for biliary-type sphincter of Oddi dysfunction has high effectiveness, but recurrences are common. Recurrences may be related to new onset or a history of functional dyspepsia. |
| first_indexed | 2024-12-11T06:42:07Z |
| format | Article |
| id | doaj.art-06625a6f7db346238607cc18f654ccb9 |
| institution | Directory Open Access Journal |
| issn | 2631-7745 |
| language | English |
| last_indexed | 2024-12-11T06:42:07Z |
| publishDate | 2019-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Gastrointestinal Endoscopy |
| spelling | doaj.art-06625a6f7db346238607cc18f654ccb92022-12-22T01:17:11ZengSAGE PublishingTherapeutic Advances in Gastrointestinal Endoscopy2631-77452019-08-011210.1177/2631774519867184Clinical course of biliary-type sphincter of Oddi dysfunction: endoscopic sphincterotomy and functional dyspepsia as affecting factorsHiroyuki MiyataniHirosato MashimaMasanari SekineSatohiro MatsumotoBackground and study aims: The objective of this study was to clarify the effectiveness of treatment selection for biliary-type sphincter of Oddi dysfunction by severe pain frequency and the risk factors for recurrence including the history of functional gastrointestinal disorder. Patients and methods: Thirty-six sphincter of Oddi dysfunction patients who were confirmed endoscopic retrograde cholangiopancreatography enrolled in this study. Endoscopic sphincterotomy was performed for type I and manometry-confirmed type II sphincter of Oddi dysfunction patients with severe pain (⩾2 times/year; endoscopic sphincterotomy group). Others were treated medically (non-endoscopic sphincterotomy group). Results: The short-term effectiveness rate of endoscopic sphincterotomy was 91%. The final remission rates of the endoscopic sphincterotomy and non-endoscopic sphincterotomy groups were 86% and 100%, respectively. Symptoms relapsed after endoscopic sphincterotomy in 32% of patients. Patients in the endoscopic sphincterotomy and non-endoscopic sphincterotomy groups had or developed functional dyspepsia in 41% and 14%, irritable bowel syndrome in 5% and 14%, and gastroesophageal reflux disorder in 14% and 0%, respectively. History or new onset of functional dyspepsia was related to recurrence on multivariate analysis. The frequency of occurrence of post-endoscopic retrograde cholangiopancreatography pancreatitis and post-endoscopic retrograde cholangiopancreatography cholangitis was high in both groups. Two new occurrences of bile duct stone cases were observed in each group. Conclusion: According to the treatment criteria, endoscopic and medical treatment for biliary-type sphincter of Oddi dysfunction has high effectiveness, but recurrences are common. Recurrences may be related to new onset or a history of functional dyspepsia.https://doi.org/10.1177/2631774519867184 |
| spellingShingle | Hiroyuki Miyatani Hirosato Mashima Masanari Sekine Satohiro Matsumoto Clinical course of biliary-type sphincter of Oddi dysfunction: endoscopic sphincterotomy and functional dyspepsia as affecting factors Therapeutic Advances in Gastrointestinal Endoscopy |
| title | Clinical course of biliary-type sphincter of Oddi dysfunction: endoscopic sphincterotomy and functional dyspepsia as affecting factors |
| title_full | Clinical course of biliary-type sphincter of Oddi dysfunction: endoscopic sphincterotomy and functional dyspepsia as affecting factors |
| title_fullStr | Clinical course of biliary-type sphincter of Oddi dysfunction: endoscopic sphincterotomy and functional dyspepsia as affecting factors |
| title_full_unstemmed | Clinical course of biliary-type sphincter of Oddi dysfunction: endoscopic sphincterotomy and functional dyspepsia as affecting factors |
| title_short | Clinical course of biliary-type sphincter of Oddi dysfunction: endoscopic sphincterotomy and functional dyspepsia as affecting factors |
| title_sort | clinical course of biliary type sphincter of oddi dysfunction endoscopic sphincterotomy and functional dyspepsia as affecting factors |
| url | https://doi.org/10.1177/2631774519867184 |
| work_keys_str_mv | AT hiroyukimiyatani clinicalcourseofbiliarytypesphincterofoddidysfunctionendoscopicsphincterotomyandfunctionaldyspepsiaasaffectingfactors AT hirosatomashima clinicalcourseofbiliarytypesphincterofoddidysfunctionendoscopicsphincterotomyandfunctionaldyspepsiaasaffectingfactors AT masanarisekine clinicalcourseofbiliarytypesphincterofoddidysfunctionendoscopicsphincterotomyandfunctionaldyspepsiaasaffectingfactors AT satohiromatsumoto clinicalcourseofbiliarytypesphincterofoddidysfunctionendoscopicsphincterotomyandfunctionaldyspepsiaasaffectingfactors |