Senkyunolide I: A Review of Its Phytochemistry, Pharmacology, Pharmacokinetics, and Drug-Likeness
Senkyunolide I (SI) is a natural phthalide that has drawn increasing interest for its potential as a cardio-cerebral vascular drug candidate. In this paper, the botanical sources, phytochemical characteristics, chemical and biological transformations, pharmacological and pharmacokinetic properties,...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/8/3636 |
| _version_ | 1797604068318773248 |
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| author | Yan Huang Yan Wu Hongxiang Yin Leilei Du Chu Chen |
| author_facet | Yan Huang Yan Wu Hongxiang Yin Leilei Du Chu Chen |
| author_sort | Yan Huang |
| collection | DOAJ |
| description | Senkyunolide I (SI) is a natural phthalide that has drawn increasing interest for its potential as a cardio-cerebral vascular drug candidate. In this paper, the botanical sources, phytochemical characteristics, chemical and biological transformations, pharmacological and pharmacokinetic properties, and drug-likeness of SI are reviewed through a comprehensive literature survey, in order to provide support for its further research and applications. In general, SI is mainly distributed in Umbelliferae plants, and it is relatively stable to heat, acid, and oxygen, with good blood–brain barrier (BBB) permeability. Substantial studies have established reliable methods for the isolation, purification, and content determination of SI. Its pharmacological effects include analgesic, anti-inflammatory, antioxidant, anti-thrombotic, anti-tumor effects, alleviating ischemia–reperfusion injury, etc. Pharmacokinetic parameters indicate that its metabolic pathway is mainly phase Ⅱ metabolism, and it is rapidly absorbed in vivo and widely distributed in the kidneys, liver, and lungs. |
| first_indexed | 2024-03-11T04:40:57Z |
| format | Article |
| id | doaj.art-06627c78e9ff4a35a9945c8f5dc1ca92 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T04:40:57Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-06627c78e9ff4a35a9945c8f5dc1ca922023-11-17T20:41:50ZengMDPI AGMolecules1420-30492023-04-01288363610.3390/molecules28083636Senkyunolide I: A Review of Its Phytochemistry, Pharmacology, Pharmacokinetics, and Drug-LikenessYan Huang0Yan Wu1Hongxiang Yin2Leilei Du3Chu Chen4School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaSichuan Provincial Key Laboratory of Quality and Innovation Research of Chinese Materia Medica, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, ChinaSchool of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaSchool of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaSichuan Provincial Key Laboratory of Quality and Innovation Research of Chinese Materia Medica, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, ChinaSenkyunolide I (SI) is a natural phthalide that has drawn increasing interest for its potential as a cardio-cerebral vascular drug candidate. In this paper, the botanical sources, phytochemical characteristics, chemical and biological transformations, pharmacological and pharmacokinetic properties, and drug-likeness of SI are reviewed through a comprehensive literature survey, in order to provide support for its further research and applications. In general, SI is mainly distributed in Umbelliferae plants, and it is relatively stable to heat, acid, and oxygen, with good blood–brain barrier (BBB) permeability. Substantial studies have established reliable methods for the isolation, purification, and content determination of SI. Its pharmacological effects include analgesic, anti-inflammatory, antioxidant, anti-thrombotic, anti-tumor effects, alleviating ischemia–reperfusion injury, etc. Pharmacokinetic parameters indicate that its metabolic pathway is mainly phase Ⅱ metabolism, and it is rapidly absorbed in vivo and widely distributed in the kidneys, liver, and lungs.https://www.mdpi.com/1420-3049/28/8/3636Senkyunolide Iphthalidephytochemistrypharmacologypharmacokineticsdrug-likeness |
| spellingShingle | Yan Huang Yan Wu Hongxiang Yin Leilei Du Chu Chen Senkyunolide I: A Review of Its Phytochemistry, Pharmacology, Pharmacokinetics, and Drug-Likeness Molecules Senkyunolide I phthalide phytochemistry pharmacology pharmacokinetics drug-likeness |
| title | Senkyunolide I: A Review of Its Phytochemistry, Pharmacology, Pharmacokinetics, and Drug-Likeness |
| title_full | Senkyunolide I: A Review of Its Phytochemistry, Pharmacology, Pharmacokinetics, and Drug-Likeness |
| title_fullStr | Senkyunolide I: A Review of Its Phytochemistry, Pharmacology, Pharmacokinetics, and Drug-Likeness |
| title_full_unstemmed | Senkyunolide I: A Review of Its Phytochemistry, Pharmacology, Pharmacokinetics, and Drug-Likeness |
| title_short | Senkyunolide I: A Review of Its Phytochemistry, Pharmacology, Pharmacokinetics, and Drug-Likeness |
| title_sort | senkyunolide i a review of its phytochemistry pharmacology pharmacokinetics and drug likeness |
| topic | Senkyunolide I phthalide phytochemistry pharmacology pharmacokinetics drug-likeness |
| url | https://www.mdpi.com/1420-3049/28/8/3636 |
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