Polymorphism: the influence on the quality of drugs and actual methods of analysis
Polymorphism is a phenomenon of existence of an individual substance in states with different crystalline structure, each of these states is called a polymorphic modification (PM). The possibility of developing new drugs by detecting the biological activity of xenobiotics is considered to be largely...
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| Format: | Article |
| Language: | Russian |
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Izdatelstvo OKI
2018-05-01
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| Series: | Качественная клиническая практика |
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| Online Access: | https://www.clinvest.ru/jour/article/view/80 |
| _version_ | 1797262084562485248 |
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| author | G. N. Gildeeva |
| author_facet | G. N. Gildeeva |
| author_sort | G. N. Gildeeva |
| collection | DOAJ |
| description | Polymorphism is a phenomenon of existence of an individual substance in states with different crystalline structure, each of these states is called a polymorphic modification (PM). The possibility of developing new drugs by detecting the biological activity of xenobiotics is considered to be largely exhausted, so recently, along with the search and development of new drugs, the task of improving known drugs, in particular, through the use of medicinal substances (MS) based on a certain PM of the active substance. Such technologies allow improving the properties, ensuring the quality and safety of drugs at a higher level, and also reducing the costs of developing patent-protected drugs, which contributes to the development of the pharmaceutical industry. |
| first_indexed | 2024-04-24T23:51:29Z |
| format | Article |
| id | doaj.art-066399021fbe46a3a2f43bfe80fb6d65 |
| institution | Directory Open Access Journal |
| issn | 2588-0519 2618-8473 |
| language | Russian |
| last_indexed | 2024-04-24T23:51:29Z |
| publishDate | 2018-05-01 |
| publisher | Izdatelstvo OKI |
| record_format | Article |
| series | Качественная клиническая практика |
| spelling | doaj.art-066399021fbe46a3a2f43bfe80fb6d652024-03-14T18:09:04ZrusIzdatelstvo OKIКачественная клиническая практика2588-05192618-84732018-05-0101566080Polymorphism: the influence on the quality of drugs and actual methods of analysisG. N. Gildeeva0ФГБОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава РоссииPolymorphism is a phenomenon of existence of an individual substance in states with different crystalline structure, each of these states is called a polymorphic modification (PM). The possibility of developing new drugs by detecting the biological activity of xenobiotics is considered to be largely exhausted, so recently, along with the search and development of new drugs, the task of improving known drugs, in particular, through the use of medicinal substances (MS) based on a certain PM of the active substance. Such technologies allow improving the properties, ensuring the quality and safety of drugs at a higher level, and also reducing the costs of developing patent-protected drugs, which contributes to the development of the pharmaceutical industry.https://www.clinvest.ru/jour/article/view/80полиморфизмполиморфные модификацииактивная фармацевтическая субстанциякристаллическая структуракристаллические модификацииpolymorphismpolymorphic modificationsactive pharmaceutical substancecrystal structurecrystal modifications |
| spellingShingle | G. N. Gildeeva Polymorphism: the influence on the quality of drugs and actual methods of analysis Качественная клиническая практика полиморфизм полиморфные модификации активная фармацевтическая субстанция кристаллическая структура кристаллические модификации polymorphism polymorphic modifications active pharmaceutical substance crystal structure crystal modifications |
| title | Polymorphism: the influence on the quality of drugs and actual methods of analysis |
| title_full | Polymorphism: the influence on the quality of drugs and actual methods of analysis |
| title_fullStr | Polymorphism: the influence on the quality of drugs and actual methods of analysis |
| title_full_unstemmed | Polymorphism: the influence on the quality of drugs and actual methods of analysis |
| title_short | Polymorphism: the influence on the quality of drugs and actual methods of analysis |
| title_sort | polymorphism the influence on the quality of drugs and actual methods of analysis |
| topic | полиморфизм полиморфные модификации активная фармацевтическая субстанция кристаллическая структура кристаллические модификации polymorphism polymorphic modifications active pharmaceutical substance crystal structure crystal modifications |
| url | https://www.clinvest.ru/jour/article/view/80 |
| work_keys_str_mv | AT gngildeeva polymorphismtheinfluenceonthequalityofdrugsandactualmethodsofanalysis |