Benzylidene/2-aminobenzylidene hydrazides: Synthesis, characterization and in vitro antimicrobial evaluation
In this study a series of new mannich bases were synthesized and characterized by elemental and spectral (IR, 1H NMR, 13C NMR) studies. All the synthesized compounds were evaluated for their antimicrobial activity by broth dilution method against two Gram negative strains (Escherichia coli and Pseud...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-11-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535210002649 |
| _version_ | 1819265359533834240 |
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| author | Manav Malhotra Rajiv Sharma Dharmender Rathee Priyanka Phogat Aakash Deep |
| author_facet | Manav Malhotra Rajiv Sharma Dharmender Rathee Priyanka Phogat Aakash Deep |
| author_sort | Manav Malhotra |
| collection | DOAJ |
| description | In this study a series of new mannich bases were synthesized and characterized by elemental and spectral (IR, 1H NMR, 13C NMR) studies. All the synthesized compounds were evaluated for their antimicrobial activity by broth dilution method against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa), two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strain (Candida albicans and Aspergillus niger). Preliminary pharmacological evaluation revealed that the compounds (3f, 3i, 3j, and 3k) showed good activity against these strains. The result demonstrates the potential and importance of developing new mannich bases which would be effective against resistant bacterial and fungal strain. |
| first_indexed | 2024-12-23T20:44:08Z |
| format | Article |
| id | doaj.art-06639ac0a6ba430c8ea4314335c9e038 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-23T20:44:08Z |
| publishDate | 2014-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-06639ac0a6ba430c8ea4314335c9e0382022-12-21T17:31:51ZengElsevierArabian Journal of Chemistry1878-53522014-11-017566667110.1016/j.arabjc.2010.11.016Benzylidene/2-aminobenzylidene hydrazides: Synthesis, characterization and in vitro antimicrobial evaluationManav Malhotra0Rajiv Sharma1Dharmender Rathee2Priyanka Phogat3Aakash Deep4Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ferozpur Road, Moga 142 001, IndiaDepartment of Pharmaceutical Chemistry, ISF College of Pharmacy, Ferozpur Road, Moga 142 001, IndiaDeptartment of Pharmacognosy and Phytochemistry, Jan Nayak Ch. Devi Lal Memorial College of Pharmacy, Sirsa 125 055, IndiaDepartment of Pharmaceutical Sciences, Hindu College of Pharmacy, Sonepat 131 001, IndiaDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124 001, IndiaIn this study a series of new mannich bases were synthesized and characterized by elemental and spectral (IR, 1H NMR, 13C NMR) studies. All the synthesized compounds were evaluated for their antimicrobial activity by broth dilution method against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa), two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strain (Candida albicans and Aspergillus niger). Preliminary pharmacological evaluation revealed that the compounds (3f, 3i, 3j, and 3k) showed good activity against these strains. The result demonstrates the potential and importance of developing new mannich bases which would be effective against resistant bacterial and fungal strain.http://www.sciencedirect.com/science/article/pii/S1878535210002649Mannich basesIsoniazidAntibacterialAntifungal activity |
| spellingShingle | Manav Malhotra Rajiv Sharma Dharmender Rathee Priyanka Phogat Aakash Deep Benzylidene/2-aminobenzylidene hydrazides: Synthesis, characterization and in vitro antimicrobial evaluation Arabian Journal of Chemistry Mannich bases Isoniazid Antibacterial Antifungal activity |
| title | Benzylidene/2-aminobenzylidene hydrazides: Synthesis, characterization and in vitro antimicrobial evaluation |
| title_full | Benzylidene/2-aminobenzylidene hydrazides: Synthesis, characterization and in vitro antimicrobial evaluation |
| title_fullStr | Benzylidene/2-aminobenzylidene hydrazides: Synthesis, characterization and in vitro antimicrobial evaluation |
| title_full_unstemmed | Benzylidene/2-aminobenzylidene hydrazides: Synthesis, characterization and in vitro antimicrobial evaluation |
| title_short | Benzylidene/2-aminobenzylidene hydrazides: Synthesis, characterization and in vitro antimicrobial evaluation |
| title_sort | benzylidene 2 aminobenzylidene hydrazides synthesis characterization and in vitro antimicrobial evaluation |
| topic | Mannich bases Isoniazid Antibacterial Antifungal activity |
| url | http://www.sciencedirect.com/science/article/pii/S1878535210002649 |
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